Laboratory of Bioinorganic Chemistry and Nanocompozite

laborator CBN

Head of the laboratory dr. habilitate, assoc. prof. Vasile LOZAN

Office:  230
Phone: (+373 22) 73 97 55
Email: vasile.lozan @ sti.usm.md
vasilelozan @ gmail.com

 

 



Short history

The laboratory of Bioinorganic Chemistry and Nanocomposites was founded in 1975 (under the name Laboratory of Bioinorganic Chemistry) by dr. habilitate, professor Dumitru Batir. The laboratory was founded to study coordination compounds with biological activity. At the end of 1988, acad. Constantin Turta was elected as head of the laboratory, giving it a new breath by implementing progressive methods (at that time) Nuclear Gamma Resonance Spectroscopy (Mössbauer spectroscopy) and magnetochemistry.

In 2006, with the creation of the Center of Physical Chemistry and Nanocomposites the laboratory was renamed in Laboratory of Bioinorganic Chemistry and Nanocomposites.

Research areas
  • Synthesis and study of new homo-, heteronuclear and polymeric coordination combinations of ns-, 3d- and 4f-type metals with carboxylic acids and Schiff bases, as well as mono- and polydidentate ligands with various donor atoms;
  • Investigation of their molecular and crystalline structure by X-ray diffraction method on monocrystal and powder of synthesized compounds (in collaboration with other institutions);
  • Deciphering of IR, UV/Vis,  Mössbauer,  NMR,  TG and EPR spectra, as well as sorbtion of the synthesized coordination compounds;
  • Testing of compounds synthesized as single molecule-magnets (SMM), catalysts, porous polymeric compounds, magnetic  nanomaterials  and biologically active substances. The laboratory is endowed with a Gouy apparatus to measure the magnetic susceptibility of the complexes in the 300- 110 K temperature range, a Mössbauer spectrometer of the electrodynamic type with the 300-80 K measuring range, the Cyclovoltamperometric installation. It has access to IR, UV-Vis, NMR, TG, EPR and X-ray diffraction methods on monocrystale and powder.
Staff
Recent publications
Research projects
Noutăți

Vasile LOZAN
dr. habilitate, assoc. prof.
Head of the laboratory

office 230
phone: (+373 22) 73 97 55
email: vasile.lozan @ sti.usm.md;
vasilelozan @ gmail.com; vasile.lozan @ ichem.md

Vadim DRUTA
dr., assoc. prof.
Leading scientific researcher

office 247
phone: (+373 22) 73 97 22
email: vadim.druta @ sti.usm.md;
vaddr22 @ yahoo.com; vadim.druta @ ichem.md

Olesea CUZAN
dr.
Senior scientific researcher

office 210
phone: (+373 22) 73 97 55
email: olesea.cuzan @ sti.usm.md;
olesea_cuzan @ yahoo.comolesea.cuzan-munteanu @ ichem.md

Silvia MELNIC
dr.
Senior scientific researcher

office 210
phone: (+373 22) 73 79 55
email: silmel_sm @ yahoo.com; silvia.melnic @ ichem.md

Sergiu SHOVA
dr
Senior scientific researcher

office 210
phone: (+373 22) 73 79 55
email: shova @ icmpp.ro

Diana DRAGANCEA
dr., assoc. prof.
Senior scientific researcher

office 206
phone: (+373 22) 73 79 55
email: diana.dragancea @ sti.usm.md;
ddragancea @ gmail.com, diana.dragancea @ ichem.md

Tudor JOVMIR
Scientific researcher

office 201a
phone: (+373 22) 73 79 55
email:  tudor.jovmir @ sti.usm.md;
tjovmir @ gmail.com, tudor.jovmir @ ichem.md

Viorina GORINCIOI
dr.
Scientific researcher

office 216
phone: (+373 22) 73 97 22
email:  viorina.gorincioi @ sti.usm.md;
oviorina @ gmail.com, viorina.gorincioi @ ichem.md

Irina VODA
Scientific researcher

office 247
phone: (+373 22) 73 97 22
email: irina.voda @ sti.usm.md;
irinavoda86 @ mail.ru; irina.voda @ ichem.md

Elena NEGUTA
Scientific researcher
office 213
phone: (+373 22) 73 97 22
email: neguta26elena @ gmail.com
Ion DERIVOLCOV
Stagiar scientific researcher
office 201
phone: (+373 22) 73 97 22
email:  ion.derivolcov @ sti.usm.md
derivolcov99 @ gmail.com 

Articles in international journals

  1. BEJAN, D.;, BAHRIN, L.-G.; SHOVA, S.; MARANGOCI, N.L.; KOKCAM-DEMIR, U.;LOZAN, V.; JANIAK, C. New microporous lanthanide organic frameworks. Synthesis,structure, luminescence, sorption, and catalytic acylation of 2-naphthol. Molecules. 2020,25, 3055; doi:10.3390/molecules25133055 (IF 3.267)
  2. CUZAN-MUNTEANU, O.; SIRBU, D.; GIORGI, M.; SHOVA, S.; GIBSON, E.A.; RÉGLIER, M.; ORIO, M.; MARTINS, L.M.D.R.S.; BENNISTON, A.C. Neutral Lipophilic Palladium(II) Complexes and their Applications in Electrocatalytic Hydrogen Production and C‐C Coupling Reactions. European Journal of Inorganic Chemistry. 2020,10, 813-822. ISSN 1099-0682. doi: 10.1002/ejic.201901283 (IF: 2.578).
  3.  LOZAN V.; MAKHLOUFI G.; DRUTA V.; BOUROSH P.; KRAVTSOV V.; MARANGOCI N.; HEERING C.; JANIAK Ch. Synthesis and structure of zinc(II) and cobalt(II) coordination polymers involving the elongated 2’, 3’, 5’, 6’ tetramethylterphenyl-4, 4”-dicarboxylate ligand. Inorgcanica Chimica Acta, 2020, 506, 119500. doi.org/10.1016/j.ica.2020.119500 (IF: 2,433).
  4. BRATANOVICI, B.-I.; NICOLESCU, A.; SHOVA, S.; DASCĂLU, I.-A.;ARDELEANU, R.; LOZAN, V.; ROMAN, Gh. Design and synthesis of novel ditopic ligands with a pyrazole ring in the central unit. Research on Chemical Intermediates. 2020, 46, 1587–1611. (I.F. 2,064) https://doi.org/10.1007/s11164-019-04052-3.
  5. BAHRIN, L.-G.; BEJAN. D.; SHOVA, S.; GDANIEC, M.; FRONC, M.; LOZAN, V.; JANIAK, C. Alkali- and alkaline-earth metal–organic networks based on a tetra(4-Carboxy-phenyl) bimesitylene-linker, Polyhedron, 2019, 173, 114128, https://doi.org/10.1016/j.poly.2019.114128 (I.F. 2.343)
  6. DASCĂLU, I.-A., MIKHALYOVA, E., SHOVA, S., BRATANOVICI, B.I., ARDELEANU, R., MARANGOCI, N.L., LOZAN, V., ROMAN, G. Synthesis, crystal structure and luminescent properties of isoreticular lanthanide–organic frameworks based on a tetramethyl-substituted terphenyldicarboxylic acid. In: Polyhedron, 2021, nr. 194. ISSN 0277-5387, DOI:10.1016/j.poly.2020.114929 (IF = 2.88)
  7. BRATANOVICI, B.-I., SHOVA, S., LOZAN, V., DASCALU, I.-A., ARDELEANU, R., ROMAN, G. 1-(4-Carboxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid – A versatile ligand for the preparation of coordination polymers and mononuclear complexes. In: Polyhedron, v.200, 15 May 2021, https://doi.org/10.1016/j.poly.2021.115115. (IF = 2.88)
  8. CUBA, L.; GORINCIOI, E.; DRAGANCEA, D.; SHOVA, S.; BOUROSH, P. Noncovalent Interactions in the Architectures with Substituted Salicylaldehyde Semicarbazones. In: Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya. 2021, nr. 7(47), pp.488-501, DOI: 10.1134/S1070328421070034 (IF = 1,168)
  9. DRAGANCEA, D., NOVITKI, Gh., MADALAN, A.M., ANDRUH, M. New cyanido-bridged heterometallic 3d-4f 1D coordination polymers: Synthesis, crystal structures and magnetic properties. In: Magnetochemistry. 2021, nr. 5(7), pp. 1-14. ISSN 2312-7481, DOI:10.3390/magnetochemistry7050057. (IF = 2,193)
  10. GULEA, A., GRAUR, V.О., ULCHINA, I., BOUROSH, P., SMAGLII, V., GARBUZ, O., TSAPKOV, V.I. Synthesis, Structure, and Biological Activity of Mixed-Ligand Amine-Containing Copper(II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide. In: Russian Journal of General Chemistry. 2021, nr. 1(91), pp. 98-107. ISSN 1070-3632, DOI: 10.1134/S1070363221010114. (IF = 0,81)
  11. ARAUZO, A., BARTOLOME, B., LUZON, J., ALONSO-GUTIÉRREZ, P., VLAD, A., CAZACU, M., ZALTARIOV, M.-F., SHOVA, S., BARTOLOME, J., TURTA, C. In: Molecules. Basel, Switzerland. 2021, nr. 18(26), pp. 1-26. , DOI: 10.3390/molecules26185626. (IF = 4,411)
  12. TSYMBAL, L.V., ANDRIICHUK, I.L., LOZAN, V., SHOVA, S., LAMPEKA, Y.D. Synthesis and crystal structure of diaqua(1,4,8,11-tetraazacyclotetradecane) zinc(II) bis(hydrogen-4-phosphonato-biphenyl-40-carboxylato)(1,4,8,11-tetraazacyclotetradecane) zinc(II). In: Acta Cryst. 2022. E78, 625–628.https://doi.org/10.1107/S2056989022004534.
  13. CUZAN,O.; SHOVA, S.; NOVITCHI, G.; LOZAN, V. Synthesis, characterization and magnetochemical study of cobalt, nickel and manganese coordination polymers, Inorganica Chimica Acta, 2023, 553, pp. 121526. ISSN 0020-1693, DOI: 10.1016/j.ica.2023.121526 (IF: 3.118)
  14. TERENTI, N.; MELNIC, E.; FRUTH, V.; NEDELKO, N.; ALESHKEVYCH, P.;  LEWINSKA, S.; SLAWSKA-WANIEWSKA, A.; KRAVTSOV, V.Ch.; LAZARESCU, A.; LOZAN, V. Synthesis and microstructure of BaMnO3 oxide obtained from coordination precursor. Journal of Solid State Chemistry V.324, August 2023, 124108  https://doi.org/10.1016/j.jssc.2023.124108 (IF: 3,656)


Patents

  1. LUPAŞCU, L.; JOVMIR, T.; POPA, T.; LOZAN, V. Aplicare a 2,6-bis(S-metilizotiosemicarbazidometiliden) -4-metilfenolato- tricloro- dicupru hidrat în calitate de remediu contra bacteriilor fitopatogene. Brevet de invenție MD 4663. 2019-12-31.
  2. JOVMIR, T.; BURDUNIUC, O.; POPA, T.; DRUŢĂ, V.; GULEA, A.; LOZAN, V. Compus hidrosolubil 2,6- bis (S-metilizotiosemicarbazidometiliden)-4-metilfenolato-tricloro- dicupru- hidrat pentru utilizare în calitate de remediu antimicotic. Brevet de invenție MD 4696, B1.2019.04.04, BOPI 5/2020, p. 67.
  3. JOVMIR, T.; BĂLAN, G.; POPA, T.; DRUŢĂ, V.; GULEA, A.; LOZAN, V. Compus hidrosolubil 2,6- bis(S-metilizotiosemicarbazidometiliden)-4-metilfenolato-tricloro- dicupru-hidrat pentru utilizare în calitate de remediu farmaceutic selectiv contra bacteriilor Gram-pozitive. Brevet de invenție MD 4687 B1, 2019.04.04, BOPI nr. 04/2020, p. 41.
  4. GORINCHOY, V.; LOZAN, V.; BURDUNIUC, O.; BALAN, G.; TSAPCOV, V.; GULEA A. Utilizarea tetrasalicilatului de bariu-cupru în calitate de inhibitor al proliferării fungilor din specia Cryptococcus Neoformans. BOPI nr.9/2020, 4712 B1 (2020.09.30).
  5. JOVMIR, T., BĂLAN, G., POPA, T., DRUȚĂ, V., GULEA, A., LOZAN V.  Compus hidrosolubil 2,6-bis(S-metilizotiosemicarbazidometilen)-4-metilfenolato-tricloro-dicupru hidrat în calitate de remediu farmaceutic selectiv contra bacteriilor Gram-pozitive. Brevet de invenție MD4687 C1, data eliberării 2021.01.31.
  6. JOVMIR, T.,BURDUNIUC, O.,POPA, T., DRUȚĂ, V., GULEA, A., LOZAN, V. MD4696 C1, Compus hidrosolubil 2,6-bis(S- metilizotiosemicarbazidometi-len)-4-metilfenolato-tricloro-dicupru hidrat în calitate de remediu antimicotic.  Brevet de invenție MD4696 C1, data eliberării 2021.02.28.
  7. LOZAN V., JOVMIR T.; PARȘUTIN Vl., COVALI Al. Procedeu de protecția a oțelului de coroziune în apă. Brevet de invenție MD1615 Y; Data publicării: 2021-04-30.
  8. LOZAN, V., PARȘUTIN, Vl., COVALI, Al., JOVMIR, T. Procedeu de protecție a oțelurilor contra coroziunii în apă. Brevet de invenție MD1534 Z; data eliberării 2021.12.31.
  9. GULEA, A., GRAUR, V., ȚAPCOV, V., BĂLAN, G., LOZAN, V.  Utilizarea  cloro-{N-prop-2-en-1-il-N'-[1-(piridin-2-il)etilidencarbamohidrazontioato}cupru în calitate de inhibitor al proliferării bacteriilor din specia Acinetobacter baumannii.  Brevet de invenție MD nr. 4810. Publicat BOPI. Nr. 6/2022. P. 50
  10. LOZAN, V., PARSHUTIN, Vl., COVALI, Al., JOVMIR, T. Procedeu de protecție a oțelului de coroziune în apă.  Brevet de invenție, MD 1726 Y 2023.11.30. BOPI nr.11/2023.
  11. GULEA, A., GRAUR, V., BALAN, G., ȚAPCOV, V., TODERAȘ, I., LOZAN, V. Nitrato- (N-(prop-2-en-1-il)-N,-(1-(piridin-2-il)-etiliden)carbamohidrazontio) cupru, care manifestă activitate antimicrobiană față de bacteriile din specia Streptococcus pneumoniae. Brevet de inventie, MD4842 C1 2023.01.31 BOPI nr.1/2023.


Methodical guide

  1. DRUŢĂ, V.; GÎNSARI, I.; DRUŢĂ, R. Chimia fizică. Îndrumar de laborator, Ch.: UnAȘM, 2017, 46 p. ISBN 978-9975-108-39-3

National projects

  1. Synthesis and study of new materials based on coordination compounds with polyfunctional ligands and with useful properties in medicine, biology and technology (code 010602)
    Period: 2024-2027
    Subprogram manager: dr. habilitate, assoc. prof. Vasile LOZAN
     
  2. ANCD/20.80009.5007.04. New materials based on coordination compounds of metals with polyfunctional ligands as porous polymers, catalysts, biologically active substances and nanostructured compounds
    Period: 2020-2023
    Project manager: Dr. habilitate, assoc. prof. Vasile LOZAN
     
  3. CSSDT/15.817.02.01F. Mono- and polynuclear coordination compounds of metals (transition and s-type) as photocatalyst, porous and nanostructured materials for water photolysis as components of energetical security
    Period: 2015-2019
    Project manager: Dr. habilitate, assoc. prof. Vasile LOZAN
     
  4. CSȘDT/16.00353.02.01F. New mono- and polynuclear s- and 3d-metals combination compounds as catalysts, porous substances and precursors of nanomaterials
    Period: 2016-2017
    Project manager: Dr. habilitate, assoc. prof. Vasile LOZAN
     
  5. CSȘDT/14.518.04.08A. Synthesis and study of polynuclear complexes of s-nd-4f metals as catalysts in chemical processes, porous substances and precursors of nanomaterials
    Period: 2014-2015
    Project manager: Dr. habilitate, assoc. prof. Vasile LOZAN
     

Bilateral projects

  1. AȘM-BMBF/13.820.08.03/GF.  Robust porous coordinative polymers
    Period: 2013-2015
    Project manager: Dr. habilitate, assoc. prof. Vasile LOZAN
     

International projects

  1. H2020/CMCE-EU-RI. Development of international cooperation in the field of research “Water photolysis” (DCIDCPRFA)
    Period: 2015-2016
    Project manager: Dr. habilitate, assoc. prof. Vasile LOZAN

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