Laboratory of Organic Synthesis

LSO1

Head of the laboratory dr. habilitate, prof. Fliur MACAEV
 

Office:  439
Phone: (+373 22) 73 97 54
Email: flmacaev @ gmail.com
fliur.macaev @ ichem.md



 

Short history

The Laboratory of Organic Synthesis was established in 1962 on the initiative of dr. Alexandr Shamshurin. The first researches were oriented towards obtaining preparations for pests control and of several compounds with useful properties.

Renamed in 1976, the Laboratory of Chemistry of Preservatives, during 1972-1982, was headed by dr. habilitate Grigore Junghietu. In 1984 dr. Miron Krimer took the lead of the laboratory, which was then named the Laboratory of Pesticides Chemistry, and in 1991 named again the Laboratory of Organic Synthesis.

Research areas
  • Various aspects of organic and medicinal chemistry;
  • Obtaining of new catalysts (metal-mediated and metal-free) for asymmetric synthesis, mechanistic investigations of reactions which proceed with high levels of regio- and stereoselectivity;
  • Ionic liquids as green alternatives to solvents and the total synthesis of biologically active products with the use of computer-aided molecular design and structure-activity analysis;
  • Total synthesis of biologically active compounds using computational methods of prognosis of biological activity.
Staff
Recent publications
Research projects
Fliur MACAEV
dr. habilitate, prof.
Head of the laboratory

office  430
phone: (+373 22) 73 97 54
email: flmacaev @ gmail.com, fliur.macaev @ ichem.md

Serghei POGREBNOI
dr., assoc. prof.

Leading scientific researcher

office  303
phone: (+373 22) 73 97 58
Email: richserg @ gmail.com, serghei.pogrebnoi @ ichem.md 
Lucian LUPASCU
dr.
Leading scientific researcher
office  312a
phone: (+373 22) 73 99 92
email: lucian1978 @ mail.ru, lucian.lupascu @ ichem.md
 
Eugenia STINGACI
dr.
Senior scientific researcher
office 302
phone.: (+373 22) 73 97 58
email: stingacieugenia @ gmail.com
 
Natalia SUCMAN
dr.
Senior scientific researcher
office  319
phone: (+373 22) 73 97 58
email: nicheli @ yandex.ru, natalia.sucman @ ichem.md
 
Elena GORINCIOI  
dr., assoc. prof.
Senior scientific researcher
office  415
phone: (+373 22) 73 97 58
email:  [email protected]gmail.com, [email protected]
 
Dmitri BILAN  
Scientific researcher
office  405
phone: (+373 22) 73 97 58
email: dmibilan @ yandex.ru, dumitru.bilan @ ichem.md
 
Marina ZVEAGHINȚEVA  
Scientific researcher
office  409
phone: (+373 22) 73 97 58
email: mari6azv @ mail.ru, marina.zveaghinteva @ ichem.md
 
Vsevolod POGREBNOI
dr.
Scientific researcher
office  404
phone: (+373 22) 73 97 58
email: seva.antivirus @ gmail.com; vsevolod.pogrebnoi @ ichem.md
 
Natalia CIOBANU
Scientific researcher
PhD student
office  302
phone: (+373 22) 73 97 58
email: karakuianat @ mail.ru; natalia.ciobanu @ ichem.md
 
Dumitru TERTEAC
dr.
Scientific researcher
office  312a
phone: (+373 22) 73 97 58
email: dtdmitrii @ gmail.com
 
Svetlana ARMASU
Scientific researcher
office  319
phone: (+373 22) 73 97 58
email: armasu1976 @ mail.ru
 
Sergiu COJOCARU
Stagiar scientific researcher
office  405
phone: (+373 22) 73 97 58
email: sergiucojocari98 @ gmail.com

 

Monographs

  1. DUCA, GH.G.; MACAEV, F. Compounds and Materials for Drug Development and Biomedical Applications. Editura Academiei Române-Editura Istros, București-Brăvila. 2018, 307 p. ISBN 978-973-27-2944-1, ISBN 978-606-654-297-5.
  2. МАКАЕВ, Ф.З.; ЖуНГИЕТУ, Г.И. Химия лекарственных средств, Palmarium Academic publishing, Saarbrűcken, Deutscland. 2015, 585 c. ISBN 978-3-659-60059-3.
     

Chaptres in monographs

  1. DUCA, GH.G.; MACAEV, F. Carex brevicollis D.C. Alkaloids effects on human and animal health: a brief review. In:  «Compounds and Materials for Drug Development and Biomedical Applications». Ed.  Gh. Duca, F. Macaev. Editura Academiei Române-Editura Istros, București-Brăvila. 2018, p. 11-20. ISBN 978-973-27-2944-1, ISBN 978-606-654-297-5.
  2. GERONIKAKI, A.; ELEFTHERIOU, PH.; DUCA, GH.; MACAEV, F. Protein tyrosine phosphatase 1B an attractive target for treatment of diabetes type II. In: «Compounds and Materials for Drug Development and Biomedical Applications». Ed. Gh. Duca, F. Macaev. Editura Academiei Române-Editura Istros, București-Brăvila. 2018, p. 127-158. ISBN 978-973-27-2944-1, ISBN 978-606-654-297-5.
  3. RIBKOVSKAIA, Z.Y.; DUCA, GH.; MACAEV, F. Therapeutic potential of nitric oxide donors in cardiovascular disease. In: «Compounds and Materials for Drug Development and Biomedical Applications». Ed.  Gh. Duca, F. Macaev. Editura Academiei Române-Editura Istros, București-Brăvila. 2018, p. 181-214. ISBN 978-973-27-2944-1, ISBN 978-606-654-297-5.
     

Articles in international journal (SCOPUS and with IF)

  1. BILAN, D.Y.; SUCMAN, N.S.; RADUL, O.M.; DRAGALIN, I.P.; BARBA, A.N.  Synthesis of (–)-convolutamydine a derivatives and analogs, Chem. Natur. Comps.  57 (2021), p. 516-520. DOI: https://doi.org/10.1007/s10600-021-03400-3. (IF: 1.02).
  2. КУРЛАТ, С.Н.; МАКАЕВ, Ф.З. Синтез 1,2,3-триазолзамещённых 3,7,7-триметилбицикло[4.1.0]гептанолов на основе (+)-3-карена. Химия Природ. Соединений. 2021, 4, p. 625-631. (IF: 1.02).
  3. STINGACI, E.; ZVEAGHINTEVA, M.; POGREBNOI, S.; LUPASCU, L.; VALICA, V.; UNCU, L.; SMETANSCAIA, A.; DRUMEA, M.; PETROU, A.; CIRIC, A.; GLAMOCLIJA, J.; SOKOVIC, M.; KRAVTSOV, V.; GERONIKAKI, A.; MACAEV, F. New vinyl-1,2,4-triazole derivatives as antimicrobial agents: Synthesis, biological evaluation and molecular docking studies. Bioorganic & Medicinal Chemistry Letters. 2020, 30 (17), 127368. ISSN: 0960-894X. (IF: 2.572). DOI: https://doi.org/10.1016/j.bmcl.2020.127368.
  4. DUCA, Gh., POGREBNOI, S., BOLDESCU, V., AKSAKAL, F., UNCU, A., VALICA, V., UNCU, L., NEGRES, S., NICOLESCU F., MACAEV F.  Tryptanthrin analogues as inhibitors of enoyl-acyl carrier protein reductase: activity against Mycobacterium tuberculosis, toxicity, modeling of enzyme binding. Current Topics in Medicinal Chemistry, 2019, 19 (32), 609-619. ISSN:1860-7187. doi: 10.2174/1568026619666190304125740 (IF: 3.374).
  5. Richter, M., Boldescu, V., Graf, D., Streicher, F., Dimoglo, A., Bartenschlager, R., Klein, C.D. Synthesis, Biological Evaluation, and Molecular Docking of Combretastatin and Colchicine Derivatives and their hCE1‐Activated Prodrugs as Antiviral Agents. ChemMedChem, 2019, 14(4), 469-483. ISSN:1860-7187. doi: 10.1002/cmdc.201800641 (IF: 3.009).
  6. BOLDESCU V., SUCMAN N., HASSAN S., IQBAL J., NEAMTU M., LECKA J., SÉVIGNY J., PRODIUS D., MACAEV F. Ectonucleotidase inhibitory and redox activity of imidazole-based organic salts and ionic liquids. ChemMedChem, 2018, 13, 21, 2297-2304. ISSN:1860-7187. doi: 10.1002/cmdc.201800520 (IF: 3.009).
  7. BOLDESCU, V.; BEHNAM, M.A.M.; VASILAKIS, N.; KLEIN, C.D. Broad-spectrum agents for flaviviral infections: Dengue, Zika and beyond. Nature Reviews Drug discovery, 2017, 16(8):565-586. ISSN: 1474-1776. (IF: 57.00).
  8. BEHNAM, M. A. M.; NITSCHE, C.; BOLDESCU, V.; KLEIN, C. D. The Medicinal Chemistry of Dengue Virus. Journal of Medicinal Chemistry. 2016, 59 (12), 5622–5649. ISSN: 0022-2623. doi: 10.1021/acs.jmedchem.5b01653. (IF: 5.447).
  9. NEAMȚU, M.; MACAEV, F.; BOLDESCU, V.; HODOROABA, V.D.; NĂDEJDE, C.; SCHNEIDER, R. J.; PAUL, A.; ABABEI, G.; PANNE, U. Removal of pollutants by the new Fenton-like highly active catalysts containing an imidazolium salt and a Schiff base. Applied Catalysis B: Environmental. 2016, 183, 335-342. ISSN: 0926-3373. doi:10.1016/j.apcatb.2015.10.032 (IF: 8.328).
  10. Curlat, S.N.; Barba, A.N.; Boldescu, V.V.; Panekok, K.; Macaev, F.Z. Synthesis of aminoalkylated aziridines based on (+)-3-carene. Chemistry of Natural Compounds, 2019, 2, 232-236. ISSN: 0009-3130. doi: 10.1007/s10600-019-02664-0 (IF: 1.112).
  11. LUNGU, L.; CIOCARLAN, A.; BARBA, A.; SHOVA, S.; POGREBNOI, S.; MANGALAGIU, I.; MOLDOVEANU, C.; VORNICU N.; D'AMBROSIO, M.;  BABAK, M.V.; ARION, V. B.; ARICU, A. Synthesis and evaluation of biological activity of homodrimane sesquiterpenoids bearing hydrazinecarbothioamide or 1,2,4-triazole unit. Chemistry of Heterocyclic Compounds, 2019, 55(8), 716-724. doi: 10.1007/s10593-019-02526-1. (IF: 1.49).
  12. IVANCIC, A.; MACAEV, F.; AKSAKAL, F.; BOLDESCU, V.; POGREBNOI, S.; DUCA, GH. Preparation of alginate-chitosan-cyclodextrin micro- and nanoparticles loaded with anti-tuberculosis compounds. Beilstein J. Nanotechnol. 2016, 7, 1208-1218. ISSN‎: ‎2190-4286. doi: 10.3762/bjnano.7.112 (IF-2.778).
  13. KUCHKOVA, K.I; ARYCU, А.N.; SEKARA, Е.S.; BARBA, А.N.; VLAD, P.F.; МАКАЕV, F.Z.; MEL’NIK, Е.; KRAVTSOV, V.K. Synthesis and structure of homodrimane sesquiterpenoids containing 1,2,4-triazole and carbazole rings. Chemistry of Natural Compounds. 2015, 4, 684-688. ISSN: 0009-3130. doi: 10.1007/s10600-015-1384-7. (IF: 1.112).
  14. MACAEV, F.; BOLDESCU, V. Cyclodextrins in Asymmetric and Stereospecific Synthesis Symmetry. 2015, 7, 1699-1720. doi:  10.3390/sym7041699 (IF: 1.457).
  15. POGREBNOI, S.; CHIRIŢĂ C.; VALICA, V.; MACAEV, F.; CHIFIRIUC, M. C.; KAMERZAN, C.; UNCU, L.; UNCU, A.; NEGREŞ, S.; IONICĂ, F. E.; NICOLESCU, F.; MARANDIUC, I.M.; ŞTEFĂNESCU, E. Studies on the antimycobacterial action of a novel compound of the thiadiazole class, 2-(propylthio)-5H- [1,3,4]-thiadiazole[2,3-b]-quinazoline-5-one. Farmacia, 2017, 65 (1), 69-74. ISSN: 0014-8237. (IF: 1.162).
  16. POGREBNOI, V.; MACAEV, F. Synthesis of the Tetraacetate of Glycosylated. Convolutamydine A. Chemistry of Natural Compounds. 2016, 52, 86-89. ISSN: 0009-3130. doi: 10.1007/s10600-016-1553-3. (IF: 1.05).
     

Articles in other international journals

  1. КУРЛАТ, С.Н. Синтез, цитотоксичность, антиоксидантная и анти-вич активность новых бензо- и имидазолиевых солей на основе (+)-3-карена. Известия уфимского научного центра РАН, 2019, 4, 60–63. ISSN: 2222-8349. doi:10.31040/2222-8349-2019-0-4-60-63.
  2. SUCMAN, N., POGREBNOI, V., BOLDESCU, V., MACAEV, F. Diastereoselective synthesis of 3,4-dibenzoil-3,4-dihydro-1H-spiro[benzo[cd]indol-5,3'-indoline]-2,2’(2ah)-diones. UAZİMDER 2019, 1, 20-23. ISSN: 2667-7571. 
     

Articles în national journals

  1. DRUMEA, M.; STINGACI, E.; UNCU, L.; CRUDU, V.; VALICA, V.; MACAEV, F. Evaluarea activității antifungice și antibacteriene a unui nou derivat nesaturat de 1,2,4-triazol (nitrotriazon). Moldovan Medical Journal. 2021, 1(69), 93-98. ISSN 2537-6381 (Online) DOI: https://doi.org/10.52692/1857-0011.2021.1-69.19. 
  2. PODGORNII, A.; VALICA, V.; POGREBNOI, S.; LUPASCU, L.; UNCU, A.; MACAEV, F. Antimycotic activity of phenoxythiazolchloralum. Moldovan Medical Journal. 2020, 63(4), 61-64. ISSN 2537-6381 (Online) DOI: 10.5281/zenodo.4016818.
  3. IVANCIC, A. Recent trends in alginate, chitosan and alginate-chitosan antimicrobial systems. Chem. J. Moldova 2016, 11, 17-25.
  4. POGREBNOI, V. S. New N-glucosylated substituted anilines. Chem. J. Moldova 2015, 10(2), 62-67.
  5. SUCMAN, N. S.;  POGREBNOI, V. S.; OBUSHAK, M. D.; MELNIC, E.; KRAVTSOV, V. CH.; MACAEV, F. Z. The synthesis of new spirolactones from substituted isatins. Chem. J. Moldova 2015, 10 (1), 64-70.
  6. PARII, S.; VALICA, V. ; MACAEV, F.; POGREBNOI, S.; BOLDESCU, V.; STÎNGACI, E.; DUCA, GH.; IVANCIC, A.; RUSNAC, L.; NICOLAI, E.; UNGUREANU, A.; UNCU, L.; MACAEVA, A. Determinarea toxicităţii acute a unor noi compuşi chimici cu proprietăţi antituberculoase. Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe Medicale. 2015, 1, 445-451.
     

Patents

  1. MACAEV, F.; ZVEAGHINȚEVA, M.; STÂNGACI, E.; POGREBNOI, S.; LUPAŞCU, L. Utilizarea (Z)-4,4-dimetil-1-(4-nitrofenil)-2-(1H-1,2,4-triazol-1-il)pent-1-en-3-onei în  calitate de ingredient activ contra bacteriilor fitopatogene. Patent no. MD 4740B1 din 2021.02.28. BOPI nr.2/2021
  2. MACAEV, F.; BILAN, D.; RADUL, O.; BOLDESCU, V. Procedeu de sinteza diastereo- și enantioselectivă a (S)-3-hidroxi-3-((R)-2-oxociclohexil) indolin-2-onei. Patent no. MD 4689C1 din 2021.02.28. BOPI nr.2/2021
  3. MACAEV, F.; BILAN, D.; RADUL, O.; BOLDESCU, V. Procedeu de sinteză diastereo- și enantioselectivă a (S)-3-hidroxi-3-[(R)-2-oxociclohexil]indolin-2-onei. Institutul de Chimie. Patent  MD4689 B1 acordat din 30.04.2020.
  4. MACAEV, F.; STINGACI, E., POGREBNOI, S., BOLDESCU, V. (Z)-5-metil-1-(4-nitrofenil)-2-(1H-1,2,4-triazol-1-il)hex-1-en-3-onă, procedeu de sinteză şi utilizarea ei în calitate de remediu antifungic. Patent MD4703 B1 acordat din 31.07.2020.
  5. MACAEV, F.; ZVEAGHINȚEVA, M.; STÂNGACI, E.; POGREBNOI, S.; BOLDESCU, V. Compusul 2-tert-butil-3-(1H-1,2,4-triazol-1-il)-2H-cromen-2-olului și procedeu de obținere a acestuia. Institutul de Chimie. Patent MD 4665 С1 eliberat din 31.07.2020
  6. MACAEV F.; ZVEAGHINȚEVA M.; STÂNGACI,  E.; POGREBNOI S.;  BOLDESCU V. Compusul 2-terţ-butil-3-(1H-1,2,4-triazol-l-il)-2H-cromen-2-ol şi procedeu de obţinere a acestuia. Patent 4665 (MD) din 2019.12.31. BOPI 12/2019.
  7. MACAEV F., ZVEAGHINȚEVA, M.; STÂNGACI,  E.;  POGREBNOI, S.; DUCA G. Procedeu de sinteză a 3,3-dimetil-1-(1H-1,2,4-triazol-1-il)butan-2-onei. Patent MD 4505. 2018-03-31.
  8. MACAEV F., ZVEAGHINȚEVA, M.; STÂNGACI,  E.;  POGREBNOI, S.; DUCA G. Utilizarea a (Z)-4,4-dimetil-1-(4-nitrofenil)-2-(1H-1,2,4-triazol-1-il)pent-1-en-3-onei in calitate de remediu antituberculos. Patent MD 4519. 2018-04-30.
  9. MACAEV F., POGREBNOI, S.; ZVEAGHINȚEVA, M.; BOLDESCU, V.; DUCA G. Compusul 2-(propiltio)5H-[1,3,4]tidiazolo-[2,3-b]chinazolin-5-onă, care manifestă activitate antituberculoasă și procedeu de sinteză a acestuia. Patent no. 4404 (MD) din 2016.03.02. BOPI 2/2016, p. 34-35.
  10. MACAEV F., ZVEAGHINȚEVA, M.; STÂNGACI,  E.;  POGREBNOI, S.; DUCA G. Procedeu de obținere a (Z)-4,4-dimetil-1-(4-nitrofenil)-2-(1H-1,2,4-triazol-1-il)pent-1-en-3-onei. Patent MD 4515. 2018-04-30.
  11. MACAEV, F.; MEREUȚA, A.; DUCA G.; BUZHOR, S. Procedeu de reciclare a deșeurilor de mase plastice. Patent no. 949 (MD) din 2016.04.30. BOPI 4/2016, p. 34-35.

 

National projects

  1. ANCD/20.80009.5007.17. Hybrid materials functionalized with carboxyl groups based on plant metabolites with activity against human and agricultural pathogens
    Period: 2020-2023
    Project manager: dr. habilitate, prof. Fliur MACAEV
     
  2. CSSDT/15.817.02.17A. Water as medium for chemotherapeutic substances construction
    Period: 2015-2019
    Project manager: dr. habilitate, prof. Fliur MACAEV
     
  3. CSȘDT/14.518.04.08A. From natural compounds to their analogues and to the preclinical evaluation of new compounds with antituberculous properties
    Period: 2014-2015
    Project manager: dr. habilitate, prof. Fliur MACAEV
     
  4. CSȘDT/14.518.04.08A. From natural compounds to their analogues and to the preclinical evaluation of new compounds with antituberculous properties
    Period: 2014-2015
    Project manager: dr. habilitate, prof. Fliur MACAEV


Bilateral projects

  1. AȘM-STCU/17.80013.8007.10/6245STCU. Innovative nanodimensional solid multicomponent pharmaceutical forms containing hexamincobalt (III) with antiviral and antibacterial properties
    Period: 2017-2019
    Project manager: dr. habilitate, prof. Fliur MACAEV
     
  2. AȘM-ANCSI/16.80013.5007.05/Ro. Synthesis and in vitro / in vivo evaluation of novel conjugates with antimicrobial activity
    Period: 2016-2017
    Project manager: dr. habilitate, prof. Fliur MACAEV
     
  3. AȘM-ANSIIU/14.820.18.04.06/U. New antioxidants to reduce the effects of oxidative stress in hyperglycemia
    Period: 2014-2015
    Project manager: dr. habilitate, prof. Fliur MACAEV
     

Project for young researcher

1. ANCD/19.80012.50.05A. Spiro [cyclopropane-oxindole] stereoisomers with antiviral activity
   Period: 2019
   Project manager: Dr. Natalia SUCMAN

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