Laboratory of Chemistry of Natural and Biologically Active Compounds

poza

 

Head of the laboratory 
dr. habilitate, assoc. prof. Veaceslav KULCIȚKI

 

Office:  309
Phone: (+373 22) 73 99 92
Email: kulcitki @ yahoo.com




Short history

The Laboratory Chemistry of Natural Compounds was founded in 1959 and headed then by acad. Gheorghe Lazurievski. The research activity developed fruitfully and the laboratory expanded significantly by several independent research groups, covering different areas of natural product chemistry. Consequently, it was divided in 1976 into three separate laboratories: Chemistry of Steroidal Compounds (headed by dr. Petru Ceban), Chemistry of Isoprenoids (headed by dr. Dumitru Popa) and Chemistry of Ethereal-Oleaginous Plants (headed by acad. Pavel Vlad).

Later on, after several structural changes, two of these laboratories merged in 1991 into the Laboratory of Terpenoid Chemistry (headed by acad. Pavel Vlad). Then, the laboratory was renamed into the Laboratory of Chemistry of Natural and Biologically Active Compounds (2016).

Research areas
  • Targeted synthesis of polifunctionalized bioactive terpenic compounds;
  • Elaboration of methods for renewable resources valorization;
  • Elaboration   of    new   green   methods   for   the modification of natural products.
Staff
Recent publications
Research projects
Veaceslav KULCITKI
dr. habilitate, assoc.prof.
Head of the laboratory
office 309
Phone: (+373 22) 73 97 75
email: kulcitki @ yahoo.com, veaceslav.kulcitki @ ichem.md
Nicon UNGUR
dr. habilitate, assoc.prof.
Principal scientific researcher
office  301
phone: (+373 22) 73 97 75
email: nicon.ungur @ gmail.com, nicon.ungur @ ichem.md
Aculina ARICU
dr. habilitate, assoc. prof.
Principal scientific researcher
birou  308
tel.: (+373 22) 72 71 23
email: aculina.aricu @ gmail.comaculina.aricu @ ichem.md
Ion DRAGALIN
dr.  assoc. prof.
Leading scientific researcher
office  306
phone: (+373 22) 73 97 69
email: iondragalin @ yahoo.com, ion.dragalin @ ichem.md
Alexandru CIOCARLAN
dr.  conf. cerc.
Senior scientific researcher
office  304
phone: (+373 22) 73 97 69
email: algciocarlan @ yahoo.com, alexandru.ciocarlan @ ichem.md
Marina GRINCO
dr.  conf. cerc.
Senior scientific researcher
office  310
phone: (+373 22) 73 97 69
email: grinkom @ yahoo.com, marina.grinco @ ichem.md
Caleria CUCICOVA
dr.  conf. cerc.
Senior scientific researcher
office  318
phone: (+373 22) 73 97 69
email: cucicovac @ yahoo.com
Olga MORARESCU
dr. 
Scientific researcher
office  310
phone: (+373 22) 73 97 69
email: olgamorarescu7 @ gmail.com, olga.morarescu @ ichem.md
Lidia LUNGU
dr. 
Scientific researcher
office  307
phone: (+373 22) 73 97 69
email: lidialungu @ ymail.com, lidia.lungu @ ichem.md
Elena SEKARA-KUȘNIR
dr. 
Scientific researcher
office  318
phone: (+373 22) 73 97 69
email: esecara8 @ gmail.com, elena.secara-kusnir @ ichem.md
Vladilena GIRBU
dr. 
Scientific researcher
office  304a
phone.: (+373 22) 73 97 69
email: vgirbu1 @ gmail.com, vladilena.girbu @ ichem.md
Svetlana BLAJA
Stagiar scientific researcher
office  307
phone: (+373 22) 73 97 69
email: svetlana-blaja @ mail.ru, svetlana.blaja @ ichem.md

Chapters in monographs

  1. UNGUR, N.; ARICU, A.; GRINCO, M. Occurrence, Biological Activity and Synthesis of Diterpenoid Amides. In: DITERPENOIDS. TYPES, FUNCTIONS AND RESEARCH. BRANDON JONES ED., NOVA SCIENCE PUBLISHERS, INC., NEW YORK, 2017, PP. 1-38. ISBN: 978-1-53610-671-8.
  2. ARICU, A.; UNGUR, N.; DUCA, Gh. Design, targeted synthesis and study of biological activity of some polifunctional chiral terpenic compounds. In: Compounds and materials for drug development and biomedical applications, Resp. ed. Gh G. DUCA, F. Z. MACAEV, Editura Academiei Române; Editura Istros a Muzeului Brăilei „Carol I”, 2018, pp. 101-126. ISBN 978-973-27-2944-1.z


Articles in international journals (SCOPUS and with IF)

  1. GEANĂ E.-I., CIUCURE C.T., IONETE R.E., CIOCARLAN A., ARICU A., FICAI A., ANDRONESCU E. Profiling of phenolic compounds and triterpene acids in different apple (Malus domestica Borkh.) cultivars. Foods, 2021, 10(2), 267-282.  DOI: 10.3390/foods10020267 (IF: 4.092).
  2. PRUTEANU, E.; TAPPIN, N.D.; GÎRBU, V.; MORARESCU, O.; DÉNÈS, F.; KULCIŢKI, V. and RENAUD, P. Forskolin editing via radical iodo-and hydroalkylation. Synthesis, 2021, 53(07), pp. 1247-1261.  DOI: http://dx.doi.org/10.1055/s-0040-1706003. (IF: 2.675).
  3. BLAJA, S.P., LUNGU, L.V., KUCHKOVA, K.I., CIOCARLAN, A.G., BARBA, A.N., VORNICU, N., ARICU, A.N. Norlabdane compounds containing thiosemicarbazone or 1,3-thiazole fragments: Synthesis and antimicrobial activity. Chemistry of Natural Compounds. 2021, nr. 1(57), pp. 101-110. ISSN 0009-3130. https://doi.org/10.1007/s10600-021-03292-3. (IF: 0.653).
  4. ANTOCI, V., CUCU, D., ZBANCIOC, Gh., MOLDOVEANU, C., MANGALAGIU, V., AMARIUCAI-MANTU, D., ARICU, A, MANGALAGIU I. I. Bis-(imidazole/benzimidazole)-pyridine derivatives: synthesis, structure and antimycobacterial activity. In: Future Medicinal Chemistry, Part XII, 2020, 12(3), 207-222. DOI: 10.4155/fmc-2019-0063 (FI 3.841).
  5. MORARESCU, O., GRINCO, M., KULCIŢKI, V., BARBA, A., GARBUZ, O., GUDUMAC, V., GULEA, A., UNGUR, N. A straightforward synthesis of natural oxygenated ent-kaurenoic acid derivatives. In: Synthetic communications, 2021, 51(1), pp. 123-133. DOI: 10.1080/00397911.2020.1821225 (FI 1.796).
  6. Morarescu O., Grinco M., Kulciţki V., Barba A., Garbuz O., Gudumac V., Gulea A., Ungur N. A straightforward synthesis of natural oxygenated ent-kaurenoic acid derivatives. Synthetic communications, 2020, 50. DOI: 10.1080/00397911.2020.1821225 (FI 1.796).
  7. Zinicovscaia I., Gundorina S., Vergel C., Grozdov D., Ciocarlan A., Aricu A., Dragalin I., Ciocarlan N. Elemental analysis of Lamiaceae medicinal and aromatic plants growing in the Republic of Moldova using neutron activation analysis. Phytochemistry Letters. 2020, nr.35, pp. 119–127. DOI: 10.1016/j.phytol.2019.10.009 (FI 1.338).
  8. Lungu L., Ciocarlan A., Smigon C., Ozer I., Shova S., Gutu I., Vornicu N., Mangalagiu I., D'ambrosio M., Aricu A. Synthesis and evaluation of biological activity of homodrimane sesquiterpenoids bearing 1,3,4-oxadiazole or 1,3,4-thiadiazole units. Chemistry of Heterocyclic Compounds, 2020, 56(5), 578-585. DOI: 10.1007/s10593-020-02703-7 (FI 1.492).
  9. Aricu A., Kuchkova K., Secara-Cushnir E., Barba A., Ungur N., Vornicu N. Synthesis and antimicrobial activity of new drimane and homodrinane sesquiterpenoids with oxadiazole and thiadiazole fragments. Chemistry of Natural Compounds, 2020, 56(4), 656-662. DOI: 10.1007/s10600-020-03115-x (FI 1.029).
  10. D'AMBROSIO, M.; CIOCARLAN, A.; COLOMBO, E.; GUERRIERO, A.; PIZZA, C.; SANGIOVANNI, E.; DELL'AGLI, M. Structure and cytotoxic activity of sesquiterpene glycoside esters from Calendula officinalis L.: Studies on the conformation of viridiflorol. In: PHYTOCHEMISTRY, 2015, Vol. 117, p. 1-9. DOI: 10.1016/j.phytochem.2015.05.005. ISSN 0031-9422.
  11. KUCHKOVA, K.; ARICU, A.; SECARA, E.; BARBA, A.; VLAD, P.; MACAEV, F.; MELNIC, E.; KRAVTOV. V. Synthesis and structure of homodrimanic sesquiterpenoids containing 1,2,4-triazole and carbazole cycles. In: CHEMISTRY OF NATATURAL COMPOUNDS, 2015, Vol. 51, Nr. 4, p. 684-688. ISSN 0009-3130.
  12. GRINCO, M.; GÎRBU, V.; GORINCIOI, E.; BARBA, A.; KULCIŢKI, V.; UNGUR, N. The first biomimetic synthesis of a diterpenoid with the ent-verrucosin A/B skeleton. In: TETRAHEDRON LETTERS, 2016, Vol. 57, Nr 19, PP.2084–2086. DOI: 10.1016/j.tetlet.2016.03.106. ISSN 0040-4039.
  13. ARICU, A.; CIOCARLAN, A.; LUNGU, L.; BARBA, A.; SHOVA, S.; ZBANCIOC, Gh.; MANGALAGIU, I. I.; D’AMBROSIO, M.; VORNICU, N. Synthesis, antibacterial and antifungal activity of new drimane sesquiterpenoids with azaheterocyclic units”, MEDICINAL CHEMISTRY RESEARCH, 2016, Vol. 25, Nr 10, PP. 2316–2323. ISSN 1054-2523.
  14. ARICU, A. N.; KUCHKOVA, K. I.; BARBA, A. N.; DRAGALIN, I. P.; SHOVA, S. G.; VORNICU, N.; GORINCHOI, E. K.; SEKARA, E. S.; LUNGU, L.; NICULAUA, M.; UNGUR, N. D.; VLAD, P. F. Synthesis from norambreinolide, structure, and antimicrobial activity of dihomodrimane sesquiterpenoids with azine, hydrazide, and dihydrazide fragments. In: CHEMISTRY OF NATURAL COMPOUNDS, 2016, Vol. 52, No. 6, PP. 1029-1036. ISSN: 0009-3130.
  15. CIOCÂRLAN, A.; ARÎCU, A.; LUNGU, L.; EDU, C.; BARBA, A.; SHOVA, S.; MANGALAGIU, I. I.; D’AMBROSIO, M.; NICOLESCU, A.; DELEANU, C.; VORNICU, N. Synthesis of Novel Tetranorlabdane Derivatives with Unprecedented Carbon Skeleton. In: SYNLETT, 2017, Vol. 28, Nr. 5, PP. 565-571. DOI: 10.1055/s-0036-1588651. ISSN 1437-2096.
  16. CARBONE, M.; CIAVATTA, M. L.; MATHIEU, V.; INGELS, A.; KISS, R.; PASCALE, P.; MOLLO, E.; UNGUR, N.; GUO, Y.-W.; GAVAGNIN, M. Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues. In: JOURNAL OF NATURAL PRODUCTS, 2017, Vol. 80, Nr 5, PP. 1339–1346. DOI: 10.1021/acs.jnatprod.6b00941. (IF 3.28). ISSN: 0163-3864.
  17. CIOCARLAN, A.; ARICU, A.; LUNGU, L.; EDU, C.; BARBA, A.; SHOVA, S.; MANGALAGIU, I. I.; D’AMBROSIO, M.; NICOLESCU, A.; DELEANU, C.; VORNICU, N. Synthesis of Novel Tetranorlabdane Derivatives with Unprecedented Carbon Skeleton. In: SYNLETT, 2017, Vol. 28, Nr 5, PP. 565-571. DOI: 10.1055/s-0036-1588651. (IF 2.32). ISSN 1437-2096.
  18. MARI, A.; CIOCARLAN, A.; AIELLO, N.; SCARTEZZINI, PIZZA, C.; D'AMBROSIO, M. Research survey on iridoid and phenylethanoid glycosides among seven populations of Euphrasia rostkoviana Hayne from the Alps. In: PHYTOCHEMISTRY, 2017, Vol. 137, PP. 72-80. DOI: 10.1016/j.phytochem.2017.02.013. (IF 2.78) ISSN: 0031-9422.
  19. DUCA, Gh.; ARICU, A.; KUCHKOVA, K.; SECARA, E.; BARBA, A.; DRAGALIN, I.; UNGUR, N.; SPENGLER, G. Synthesis and anticancer activity of new guanidine – containing diterpenoids. In: NATURAL PRODUCT RESEARCH, 2018. ISSN: 1478-6427. doi: 10.1080/14786419.2018.1516658. (IF 1.928).
  20. ARICU, A. N.; KUCHKOVA, K. I.; SECARA, E. S.; BARBA, A. N.; DRAGALIN, I. P.; UNGUR, N. D.; MELNIK, E.; KRAVTSOV, V. KH. Synthesis and Structure of Drimane Sesquiterpenoids Containing Pyrimidine, Pyrazine, 1,2,4-triazole, and Carbazole Rings. In: CHEMISTRY OF NATURAL COMPOUNDS, 2018, Vol. 54, Nr 3, pp. 455–460. ISSN: 1573-8388 doi 10.1007/s10600-018-2378-z. (IF 0.450).
  21. D'AMBROSIO, M.; CIOCARLAN, A.; ARICU, A. Minor acetylated metabolites from Euphrasia rostkoviana. Natural and synthetic acetylated derivatives of rutin. In: NATURAL PRODUCT RESEARCH, 2018, ISSN: 1478-6427.  doi: 10.1080/14786419.2018.1530227. (IF 1.928).
  22. АРЫКУ, А. Н.; КУЧКОВА, К. И.; БАРБА, А. Н.; ДРАГАЛИН, И. П.; ШОВА, С.; ВОРНИКУ, Н.; ГОРИНЧОЙ, Е. К.; СЕКАРА, Е. С.; ЛУНГУ, Л. В.; НИКУЛАУА, М.; УНГУР, Н. Д.; ВЛАД, П. Ф. Синтез, структура и антимикробная активность дигомодримановых сесквитерпеноидов с азинным, гидразидным и дигидразидным фрагментами из норамбреинолида. In: ХИМИЯ ПРИРОДНЫХ СОЕДИНЕНИЙ, 2016, №6, с. 885-891. ISSN 0023-1150.
  23. АРЫКУ, А. Н.; КУЧКОВА, К. И.; СЕКАРА, Е. С.; БАРБА, А. Н.; ДРАГАЛИН, И. П.; УНГУР, Н. Д.; МЕЛЬНИК, Е.; КРАВЦОВ, В. Х. Cинтез и структура дримановых сесквитерпеноидов, содержащих циклы пиримидина, пиразина, 1,2,4-триазола и карбазола. In: ХИМИЯ ПРИРОДНЫХ СОЕДИНЕНИЙ, 2017, Nr. 3, PP. 386-390. ISSN 0023-1150.
  24. SÎRBU, T.; GIRBU, V.; HARGHEL, P.; RUSU, V.; UNGUR, N.; KULCIŢKI, V. Selectivity control in terpene rearrangements. A biomimetic synthesis of halimanic bicyclic core. In: SYNTHESIS, 2018, (ID: SS-2018-09-0629-OP), ISSN 1437-210X.
  25. SÎRBU, T.; GIRBU, V.;  HARGHEL, P.; RUSU, V.; UNGUR, N.; KULCIŢKI, V. Selectivity Control in Terpene Rearrangements: A Biomimetic Synthesis of the Halimanic Bicyclic Core. In: SYNTHESIS, 2019, Vol. 51, Nr 9, PP. 1995-2000. DOI: 10.1055/s-0037-1610686. (IF 2.867).
  26. DUCA, Gh.; ARICU, A.; KUCHKOVA, K.; SECARA, E.; BARBA, A.; DRAGALIN, I.; UNGUR, N.; SPENGLER, G. Synthesis and anticancer activity of new guanidine – containing diterpenoids. In: NATURAL PRODUCT RESEARCH, 2019, Vol. 33, Nr 21, PP. 3052-3056. ISSN: 1478-6427. doi: 10.1080/14786419.2018.1516658. (IF 1.928).
  27. ZINICOVSCAIA, I.; GUNDORINA S.; VERGEL K.; GROZDOV D.; CIOCARLAN A.; ARICU A.; DRAGALIN I.; CIOCARLAN N. Elemental analysis of Lamiaceae medicinal and aromatic plants growing in the Republic of Moldova using neutron activation analysis. In: PHYTOCHEMISTRY LETTERS, 2020, Vol. 35, PP. 119–127. ISSN: 1874-3900. DOI: 10.1016/j.phytol.2019.10.009. (IF 1.338).
  28. LUNGU, L.; CIOCARLAN, A.; BARBĂ, A.; SHOVA, S.; POGREBNOI, S.; MANGALAGIU, I.; MOLDOVEANU, C.; VORNICU, N.; D’AMBROSIO, M.; BABAK, M.; ARION, V.; ARICU, A. Synthesis and Evaluation of Biological Activity of Homodrimane Sesquiterpenoids Bearing Hydrazinecarbothioamide or 1,2,4-Triazole Unit. In: CHEMISTRY OF HETEROCYCLIC COMPOUNDS. 2019, Vol. 55, Nr 8, PP. 716-724. ISSN 0009-3122. DOI: 10.1007/s10593-019-02526-1. (IF 1.492).
  29. LUNGU, L.; CIOCARLAN, A.; SMIGON, C.; OZER, I.; SHOVA, S.; GUTU, I. VORNICU, N.; MANGALAGIU, I.; D’AMBROSIO, M.; ARICU, A. Synthesis, structure, antibacterial and antifungal activities of new homodrimane sesquiterpenoids with oxa- and thiadiazole units. In: CHEMISTRY OF HETEROCYCLIC COMPOUNDS. 2019, (acceptat) (I.F. 1.18).
     

Articles in other international journals

  1. УНГУР, Н.; ГРИНЬКО, М.; АРЫКУ, А.; КУЧКОВА, К. Выделение и синтез биологически активных дитерпеноидов с амидной группой. In: ФАРМАЦЕВТИЧЕСКИЙ БЮЛЛЕТЕНЬ, 2015, № 1-2, 58-71. ISSN 2224-0225.
  2. ARÎCU, A.; UNGUR, N. Compuşi terpenici biologic activi de origine naturală şi sintetică. In: AKADEMOS, 2015, Nr. 1, p. 81-86. ISSN 1857-0461.
  3. UNGUR, N.; ARICU, A. Synthetic Transformations of (-)-Sclareol and ent-Kaur-16-en-19-oic Acid in Bioactive Terpenoids. In: PHARMACEUTICAL BULLETIN, 2016, Nr. 3-4, PP. 60-63. ISSN 2224-0225.
  4. KULCITKI, V.; UNGUR, N. Selective control in the biomimetic cyclization of some terpenoids. Pharmaceutical bulletin, 2018, Nr. 3-4, ISSN 2224-0225. (IF 0.01)
  5. FUMAGALLI, M.; GUERRIERO, A.; HARGHEL, P.; DELL’AGLI, M. A bio-guided fractionation to assess the inhibitory activity of Calendula officinalis L. on the NF-kB driven transcription in human gastric epithelial cells. In: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2015, ID 727342, p. 1-8. ISSN 1741-4288.
  6. CIOCARLAN N., CIOCARLAN A., DRAGALIN I., ARICU A., ZINICOVSCAIA I., GUNDORINA I. GC–MS and neutron activation (NAA) analysis of medicinal Teucrium L. species. In: PROGRESS OF CRYOGENICS AND ISOTOP SEPARATION. 2018, Vol. 21, Nr. 2, pp. 121-129. ISSN: 1582-2575.
  7. LUPASCU, T.; CIOBANU, M.; BOTAN, V.; SANDU, I. G.; DRAGALIN, I.; MITINA, T. Removal of ammonium ions and ammonia from groundwater by oxidation processes. In: REV. CHIM. (Bucharest), 2018, Vol. 69, Nr 11, PP. 3082-3086. ISSN: 0034-7752 (I.F. 0.09).
  8. CIOCARLAN, N.; CIOCARLAN, A.; DRAGALIN, I.; ARICU, A; ZINICOVSCAIA, I.; GUNDORINA, I. GC–MS and neutron activation (NAA) analysis of medicinal Teucrium L. species. In: PROGRESS OF CRYOGENICS AND ISOTOP SEPARATION. 2019, Vol. 22, Nr. 1, PP. 55-62. (I.F. 0.032).
  9. CIOCARLAN, A.; ARICU, A.; GEANĂ, E.-I. Investigating the therapeutic potential of some medicinal plant and wild fruits based on terpenic ursolic and oleanolic acids. In: CIENT PERIODIQUE NUTRITION. 2019, Vol. 3, Nr 5, PP. 1-12.
     

Articles in national journals

  1. ARÎCU, A. The natural product chemistry of terpenoids - a tribute to the remarkable legacy of academician Pavel Vlad. Chem.J.Mold., 2021, 16 (1), pp. 8-29.  DOI: http://dx.doi.org/10.19261/cjm.2021.856.
  2. CIOCARLAN, A. (+)-Larixol and larixyl acetate: syntheses, phytochemical studies and biological activity assessments. Chem.J.Mold., 2021, 16 (1), pp. 30-45.  DOI: 10.19261/cjm.2021.836.
  3. PELEAH, E.; MELNIC, V.; DRAGALIN, I. Polichimismul intraspecific Mentha spicata. Studia Universitatis Moldaviae, 2020, 6(136), pp. 60-63. DOI: http://dx.doi.org/10.5281/zenodo.4431568.
  4. MORARESCU, O., TRAISTARI, M., BARBA, A., DUCA, G., UNGUR, N. and KULCIȚKI, V. One-step selective synthesis of 13-epi-manoyl oxide. Chem.J.Mold., 2021, 16 (1), pp. 99-104. DOI: http://dx.doi.org/10.19261/cjm.2021.820.
  5. MORARESCU, O. Synthetic transformations of ent-kaurenoic acid. In: CHEMISTRY JOURNAL OF MOLDOVA, 2015, Vol. 10, Nr. 1, p. 9-19. ISSN 1857-1727.
  6. LUNGU, L. Synthesis of New Nitrogen-Containing Drimane and Homodrimane Sesquiterpenoids from Sclareolide. In: CHEMISTRY JOURNAL OF MOLDOVA, 2015, Vol. 10, Nr. 2, p. 58-61. ISSN 1857-1727.
  7. DRAGALIN, I.; MORARESCU, O.; SEDCENCO, M.; ROSCA; R. M. Analysis of the fatty asid methyl ester in Japanese Quail fat. In: CHEMISTRY JOURNAL OF MOLDOVA, 2015, Vol. 10, Nr. 2, p. 54-57. ISSN 1857-1727.
  8. SECARA, E. Synthesis of new drimane and homodrimane lactams by Beckmann rearrangement of some ketoximes. In: CHEMISTRY JOURNAL OF MOLDOVA, 2016, Vol. 11, Nr 1, PP. 50-54. ISSN 1857-1727.
  9. DRAGALIN, I.; ARÎCU, A.; CIOCÎRLAN, N.; CIOCÎRLAN, A.; CODIŢA, V. GC-MC Analysis of the Essential Oil of Satureja subspicata BartL. Ex vis. of Moldovan Origin, In: CHEMISTRY JOURNAL OF MOLDOVA, 2016, Vol. 11, Nr 2, PP. 105-108. ISSN 1857-1727.
  10. DUCA GH., ARICU A., LUNGU L., TENU N., CIOCARLAN A., GUTU Y., DRAGALIN I., BARBA A. Synthesis of new homodrimane sesquiterpenoids containing diazine, 1,2,4-triazole and carbazole rings. In: CHEMISTRY JOURNAL OF MOLDOVA, 2018, Nr.1, PP. pp. 69-73. ISSN 1857-1727. (IF 0.03).
  11. CIOCARLAN, A.; DRAGALIN, I.; ARICU, A.; CIOCARLAN, N.; STAVARACHE, C.; DELEANU, M. Chromatographic analysis of Sylibum marianum (L.) Gaertn. fatty oil. In: CHEMISTRY JOURNAL OF MOLDOVA. 2018, Vol. 13, Nr.1, PP. 63-68. ISSN 1857-1727. (IF 0.03).
  12. CIOCARLAN, A.; DRAGALIN, I.; ARICU, A.; LUPASCU, L.; CIOCARLAN, N.; POPESCU, V. Chemical composition and antimicrobial activity of the Levisticum officinale W.D.J. Koch essential oil. CHEMISTRY JOURNAL OF MOLDOVA, 2018, Vol. 13, Nr. 2. ISSN 1857-1727. dx.doi. 10.19261/cjm.2018.514. (IF 0.03).
  13. ARICU, A.; NASTAS, R.; COCU, M. The Institute of Chemistry at 60 years anniversary. brief history, achievements and perspectives. In: CHEMISTRY JOURNAL OF MOLDOVA. 2019, Vol. 14, nr. 1, PP. 8-31. ISSN 1857-1727. (I.F. 0.052).
  14. BLAJA S. Synthesis of new di- and tri-norlabdane compounds with 2-amino-1,3-thiazole units. In: CHEMISTRY JOURNAL OF MOLDOVA, 2019, Vol. 14, Nr 2, ISSN 1857-1727. DOI: 10.19261/cjm.2019.609.  (I.F. 0.052).
  15. RUSU, V.; MAFTULEAC, A.; PETUHOV, O.; KULCIŢKI, V.; GRINCO, M.; POSTOLACHI, L.; RUSU, M. Evaluarea proprietăţilor de suprafaţă ale bentonitului Lărguţa (Republica Moldova) intercalat cu oligomeri de aluminiu. In: STUDIA UNIVERSITATIS MOLDAVIAE. SERIA “ŞTIINŢE REALE ŞI ALE NATURII”, 2015, Nr. 1 (81), p. 178-185. ISSN 1814-3237.
  16. FULGA, A. Ursolic acid do we need other derivatives? In: CURIERUL MEDICAL, 2015,  Vol.58, Nr 6, PP. 43-48. ISSN 1857-0666.
  17. GÎRBU, V. Funcționalizarea radicalică a legăturilor C-H în compușii naturali. In: STUDIA UNIVERSITATIS MOLDAVIE, Seria ştiinţe reale şi ale naturii. 2018, Nr 6 (116), PP. 77-88. ISSN 1814-3237. 
     

Patents

  1. KULCIŢKI V., GÎRBU V., PRUTEANU E., RENAUD P., DAELEMAS D., MOLLO E., DEFRANOUX F., UNGUR N. Metil ent-17-amino-kauran-19-oat cu activitate citotoxică selectivă. Hotărâre AGEPI de acordare a brevetului de invenţie Nr 9579 din 2020.08.25.
  2. CUCICOVA C., RUDIC V., ARÎCU A., CEPOI L., RUDI L., SECARA E., VALUȚA A., BARBĂ A., MISCU V., VLAD P., CHIRIAC T. N-(8,13-Biciclohomofarnesenoilamino)-carbazolul și procedeu de cultivare a cianobacteriei Nostoc linchia - Brevet de invenție, №4326, BOPI, 2015 (2), p. 26-27.
  3. CUCICOVA C., RUDIC V., ARÎCU A., CEPOI L., RUDI L., SECARA E., VALUȚA A., BARBĂ A., MISCU V., VLAD P., CHIRIAC T. 1-(8,13-Biciclohomofarnesenoil)-3-amino-1,2,4-triazolul și procedeu de cultivare a cianobacteriei Nostoc linchia - Brevet de invenție, №4327, BOPI, 2015 (2), p. 27-28.
  4. ARICU, A.; MANGALAGIU, I.; CIOCARLAN, A.; LUNGU, L.; ZBANCIOC. GH.; VORNICU, N. 11,12-Bis-p-tolil-piridazonil-drim-5(6),8(9)-dien-7-ona cu proprietăți antifungale şi antibacteriene. Brevet MD 4370BI din 2015.09.30. BOPI. 9/2015.
  5. ROBU, Ş.; PRISACARI, V.; KULCIŢKI, V.; GRINCO, M.; BARBA, A. Polymeric material with antibacterial properties based on lignin grafted with N'-(5-nitrofurfurylidene) isonicotinehydrazide. PATENT OF REPUBLIC OF MOLDOVA. NR 4506, IN: BOPI, 2017, (8), 29.
  6. ARÎCU, A.; LUNGU, L.; CIOCARLAN, A.; VORNICU, N. Compus (1R,2R,8aS)-1-((5-mercapto-1,3,4-thiadiazol-2-il)metil)-2,5,5,8atetrametildecahidro nafthalen-2-ol cu propr ietăţi antifungice şi antibacteriene. In: BREVET DE INVENȚIE Nr 4580 MD, BOPI 02/2019.
  7. ARÎCU, A.; KUCHKOVA, K.; SECARA, E.; BARBA, A.; DRAGALIN, I.; UNGUR, N. Compusul 13-amino-14,15-dinorlabd-8(9)-enă pentru utilizare în calitate de remediu antimicotic. In: BREVET DE INVENȚIE, Nr. 4573, MD, BOPI 6/2018.
  8. ARÎCU, A.; KUCHKOVA, K.; DUCA, Gh.; SECARA, E.; BARBA, A.; DRAGALIN, I.; UNGUR, N. Compusul 1-(4-((4aS,8aS)-2,5,5,8a-tetrametil-3,4,4a,5,6,7,8,8a-octahidronaftalen1-il)butan-2-il)guanidină cu activitate antiproliferativă şi citotoxică. BREVET DE INVENȚIE, Nr. 4630, MD, BOPI 5/2019, p.41.
  9. ARÎCU, A.; KUCHKOVA, K.; DUCA, Gh.; SECARA, E.; BARBA, A.; DRAGALIN, I.; UNGUR, N. Compusul N-carbamimidoil-2-((8aS)-2,5,5, 8a-tetrametil-3,4,4a,5,6,7,8,8aoctahidronaftalen-1-il)acetamidă cu activitate antiproliferativă şi citotoxică. BREVET DE INVENȚIE, Nr. 4631, MD, BOPI 5/2019, p.41-42.

National projects

  1. ANCD/20.80009.8007.03. New products with preventive and therapeutic potential basing on natural products of vegetal origin and modern methods of organic synthesis
    Period: 2020-2023
    Project manager: dr. habilitate, assoc. prof. Veaceslav KULCITKI
     
  2. CSSDT/15.817.02.14A. Elaboration of methods for obtaining valuable terpenoids by valorization of renewable resources from Republic of Moldova
    Period: 2015-2019
    Project manager: dr. habilitate, assoc. prof. Nicon UNGUR
     
  3. CSȘDT/16.00353.50.04A. Design, directed synthesis and study of antibacterial and antitumor activity of chiral terpenic compounds and their coordinative combinations with transition metals
    Period: 2016-2017
    Project manager: dr. habilitate, assoc. prof. Aculina ARICU
     

Bilateral projects

  1. AȘM-CNCI/18.80013.16.02.02/it. Synthesis of guanidine terpenoids with relevant biological activity and therapeutic potential
    Period: 2018-2019
    Project manager: Dr. habilitate, assoc. prof. Nicon UNGUR
     
  2. AȘM-STCU/18.80013.5007.01/6330STCU. Synthesis of biologically active norlabdanic compounds with heterocyclic structural units based on agricultural waste
    Period: 2018-2019
    Project manager: Dr. habilitate, assoc. prof. Aculina ARICU
     
  3. AȘM-ANCSI/16.80013.16.02.06/Ro. Directed synthesis and study of chiral complexes containing terpeno-heterocyclic ligands
    Period: 2016-2017
    Project manager: Dr. habilitate, assoc. prof. Aculina ARICU
     
  4. AȘM-STCU/15.820.18.03.07/5984STCU. Unconventional green processes for processing renewable raw materials
    Period: 2015-2017
    Project manager: Dr. habilitate, assoc. prof. Veaceslav KULCITKI
     
  5. AȘM-CNCI/15.820.16.02.02/it. Synthesis of guanidine terpenoids with relevant biological activity and therapeutic potential
    Period: 2015-2016
    Project manager: Dr. habilitate, assoc. prof. Nicon UNGUR
     

International project

  1. SCOPES/IZ73Z0-152346. Modification of natural compounds mediated by free radicals
    Period: 2015-2016
    Project manager: Dr. habilitate, assoc. prof.  Veaceslav KULCITKI

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