Laboratory of Chemistry of Natural and Biologically Active Compounds

Chapters in international/national monographs

1. ARICU, A. (ICh al USM); CIOCARLAN, A. (ICh al USM); LUNGU, L. (ICh al USM); CUCICOVA, C., BLAJA, S., SECARA, E., UNGUR N. (ICh al USM). Synthesis of Biologically Active Nitrogen and Sulfur-Containing Terpenoids. In: Fundamental and Biomedical Aspects of Redox Processes. IGI Global, 2023, pp. 369-399. https://www.igi-global.com/pdf.aspx?tid=324200&ptid=306584&ctid=15&t=Table.
2. ARÎCU, A., KULCIŢKI, V., UNGUR, N. Sclareolul–materie primă sustenabilă pentru sinteza compușilor terpenici cu valoare adăugată înaltă. In: Chimie ecologică: istorie și realizări: Academicianul Gheorghe Duca, 70 ani de la naștere. Chişinău: 2022, 86-113. ISBN 978-9975-159-05-0. https://ibn.idsi.md/vizualizare_articol/164444.
3. ARÎCU, A., LUNGU, L., BLAJA, S., CUCICOVA, C., CIOCÂRLAN, A. Sinteza și studiul activității antimicrobiene a compușilor norlabdanici cu unități structurale heterociclice. In: Acad. A. Gulea - Conferinţa Ştiinţifică Naţională cu participare Internaţională: „Materiale Avansate în Biofarmaceutică şi Tehnică”, Chişnău, 2021, 10-34.
4. UNGUR, N., MORARESCU, O. Sinteza dirijată a unor diterpenoide tetraciclice bioactive din acidul ent-kaur-16-en-19-oic. In: Acad. A. Gulea - Conferinţa Ştiinţifică Naţională cu participare Internaţională: „Materiale Avansate în Biofarmaceutică şi Tehnică”, Chişnău, 2021, 294-313.
    

Editor of abstract books

1. ARÎCU, A., KULCIȚKI, V. eds. New frontiers in natural product chemistry. Scientific seminar with international participation, VI-th edition. Book of Abstracts. Chișinău, Institute of Chemistry, 2021. DOI: https://doi.org/10.19261/nfnpc.2021. IBN: https://ibn.idsi.md/ro/collection_view/1058
2. ARÎCU, A., KULCIȚKI, V. eds. New frontiers in natural product chemistry. Scientific seminar with international participation, VII-th edition. Book of Abstracts. Chișinău, Institute of Chemistry, 2023. DOI: https://doi.org/10.19261/nfnpc.2023. IBN: https://ibn.idsi.md/ro/collection_view/2386

Articles in international journals

1. CIOCARLAN A., SHVETSOVA M., ZINICOVSCAIA I., CHALIGAVA O., GROZDOV D., ARICU A., CIOCARLAN N. Mineral composition of fifteen species of Asteraceae family growing in the Republic of Moldova using neutron activation analysis. In: Agronomy, 2024, V. 14, nr. 10, 2387-2402. (IF 3.7, Q1) https://10.3390/agronomy14102387  https://www.scimagojr.com/journalsearch.php?q=21100447811&tip=sid#google_vignette.
2. CIOCARLAN, A., LUNGU, L. , BLAJA, S., SHOVA, S., ARICU, A. Synthesis of cycle B functionalized derivatives of (+)-larixol. In: Chemistry Journal of Moldova, 2024, vol. 19(1), pp. 86-91. https://doi.org/10.19261/cjm.2024.1056
   https://www.scimagojr.com/journalsearch.php?q=21100773812&tip=sid&clean=0. (Q4)
3. CIOCARLAN, A., LUNGU, L., SHOVA, S., VORNICU, N., BOLOCAN, N., KULCITKI, V., ARICU, A. Synthesis of Antimicrobial Norlabdane Compounds with Rearranged Cycle B and Molecular Docking Studies. In: Molecules, 2024, 29(23), 5714. (IF 4.6, Q2) https://doi.org/10.3390/molecules29235714 https://www.scimagojr.com/journalsearch.php?q=26370&tip=sid. 
4. ANTOCI, V., CUCU, D., ZBANCIOC, Gh., MOLDOVEANU, C., MANGALAGIU, V., AMARIUCAI-MANTU, D., ARICU, A, MANGALAGIU I. I. Bis-(imidazole/benzimidazole)-pyridine derivatives: synthesis, structure and antimycobacterial activity. In: Future Medicinal Chemistry, Part XII, 2020, 12(3), 207-222. https://doi.org/10.4155/fmc-2019-0063 (FI 4.2).
5. MORARESCU, O., GRINCO, M., KULCIŢKI, V., BARBA, A., GARBUZ, O., GUDUMAC, V., GULEA, A., UNGUR, N. A straightforward synthesis of natural oxygenated ent-kaurenoic acid derivatives. In: Synthetic communications, 2020, 50. https://doi.org/10.1080/00397911.2020.1821225 (FI 2.1).
6. ZINICOVSCAIA, I., GUNDORINA, S., VERGEL, C., GROZDOV, D., CIOCARLAN, A., ARICU, A., DRAGALIN, I., CIOCARLAN, N. Elemental analysis of Lamiaceae medicinal and aromatic plants growing in the Republic of Moldova using neutron activation analysis. In: Phytochemistry Letters. 2020, 35, 119–127. https://doi.org/10.1016/j.phytol.2019.10.009 (FI 1.7).
7. LUNGU, L., CIOCARLAN, A., SMIGON, C., OZER, I., SHOVA, S., GUTU, I., VORNICU, N., MANGALAGIU, I., D'AMBROSIO, M., ARICU, A. Synthesis and evaluation of biological activity of homodrimane sesquiterpenoids bearing 1,3,4-oxadiazole or 1,3,4-thiadiazole units. In: Chemistry of Heterocyclic Compounds, 2020, 56(5), 578-585. https://doi.org/10.1007/s10593-020-02703-7 (FI 1.5).
8. ARICU, A., KUCHKOVA, K., SECARA-CUSHNIR, E., BARBA, A., UNGUR, N., VORNICU, N. Synthesis and antimicrobial activity of new drimane and homodrinane sesquiterpenoids with oxadiazole and thiadiazole fragments. In: Chemistry of Natural Compounds, 2020, 56(4), 656-662. https://doi.org/10.1007/s10600-020-03115-x (FI 0.8).
9. CIOCARLAN, A., LUNGU, L., BLAJA, S., DRAGALIN, I., ARICU, A. The use of some non-conventional methods in chemistry of bicyclohomofarnesenic methyl esters. In: Chemistry Journal of Moldova, 2020, 15(2), 69-77. https://doi.org/10.19261/cjm.2020.791. IBN: https://ibn.idsi.md/ro/vizualizare_articol/118145
10. CIOCARLAN, A., LUPASCU, L., ARICU, A., DRAGALIN, I., POPESCU, V., GEANA, E.I., IONETE, R.E., VORNICU, N., DULIU, O.G., HRISTOZOVA, G. AND ZINICOVSCAIA, I. Chemical composition and assessment of antimicrobial activity of lavender essential oil and some by-products. In: Plants, 2021, 10(9), 1829.  https://doi.org/10,3390/plants1091829 (FI 4.5). IBN: https://ibn.idsi.md/ro/vizualizare_articol/138166
11. PRUTEANU, E., GÎRBU, V., UNGUR, N., PERSOONS, L., DAELEMANS, D., RENAUD, P., KULCIȚKI, V. Preparation of antiproliferative terpene-alkaloid hybrids by free radical-mediated modification of ent-kauranic derivatives. In: Molecules, 2021, 26(15), 4549. https://doi.org/10.3390/molecules26154549 (FI 4.6).
12. GEANĂ, E.-I., CIUCURE, C.T., IONETE, R.E., CIOCARLAN, A., ARICU, A., FICAI, A., ANDRONESCU, E. Profiling of phenolic compounds and triterpene acids in different apple (Malus domestica Borkh.) cultivars. In: Foods, 2021, 10(2), 267-282.  https://doi.org/10.3390/foods10020267 (FI 5.2). IBN: https://ibn.idsi.md/ro/vizualizare_articol/126448
13. MORARESCU, O., GRINCO, M., KULCIŢKI, V., SHOVA, S., UNGUR, N. An Alternative Approach towards C-12 Functionalized Scalaranic Sesterterpenoids. Synthesis of 17-Oxo-20-norscalaran-12α,19-O-lactone. In: Marine Drugs, 2021, 19(11), 636.  https://doi.org/10.3390/md19110636 (FI 5.4).
14. PRUTEANU, E., TAPPIN, N.D., GÎRBU, V., MORARESCU, O., DÉNÈS, F., KULCIŢKI, V., RENAUD, P. Forskolin Editing via Radical Iodo-and Hydroalkylation. In: Synthesis, 2021, 53(07), 1247-1261. https://doi.org/10.1055/s-0040-1706003 (FI 2.6). IBN: https://ibn.idsi.md/ro/vizualizare_articol/125941
15. BLAJA, S.P., LUNGU, L.V., KUCHKOVA, K.I., CIOCARLAN, A.G., BARBA, A.N., VORNICU, N., ARICU, A.N. Norlabdane Compounds Containing Thiosemicarbazone or 1,3-Thiazole Fragments: Synthesis and Antimicrobial Activity. In: Chemistry of Natural Compounds, 2021, 57(1), 101-110. https://doi.org/10.1007/s10600-021-03292-3 (FI 0.8). IBN: https://ibn.idsi.md/ro/vizualizare_articol/126852
16. ARÎCU, A. The natural product chemistry of terpenoids - a tribute to the remarkable legacy of academician Pavel Vlad. In: Chemistry Journal of Moldova. 2021, 16(1), 8-29. https://doi.org/10.19261/cjm.2021.856. IBN: https://ibn.idsi.md/ro/vizualizare_articol/134250
17. CIOCARLAN A., LUPASCU L., ARICU A., DRAGALIN I., CIOCARLAN N., ZINICOVSCAIA I., SLANINA V., YUSHIN N. Chemical composition of the essential oil and antimicrobial properties of crude extract from Tanacetum corymbosum (L.). In: Chemistry Journal of Moldova, 2021, 16(2), 83-90. https://doi.org/10.19261/cjm.2021.877.
18. CIOCARLAN, A. (+)-Larixol and larixyl acetate: syntheses, phytochemical studies and biological activity assessments. In: Chemistry Journal of Moldova. 2021, 16(1), 30-45. https://doi.org/10.19261/cjm.2021.836 IBN: https://ibn.idsi.md/ro/vizualizare_articol/134251
19. MORARESCU, O., TRAISTARI, M., BARBA, A., DUCA, G., UNGUR, N. AND KULCIȚKI, V. One-step selective synthesis of 13-epi-manoyl oxide. In: Chemistry Journal of Moldova, 2021, 16(1), 99-104. http://dx.doi.org/10.19261/cjm.2021.820.
20. MORARESCU, O., GRINCO, M., KULCITKI, V. et al. Synthesis of highly functionalized biologically active tetracyclic diterpenoids from ent-kaur-16-en-19-oic acid under modified Prévost-Woodward reaction conditions. In: Russian Journal of Organic Chemistry, 2021, 57, 1931–1939. https://doi.org/10.1134/S1070428021120058 (FI 0.8).
21. CIOCARLAN A., HRISTOZOVA G., ARICU A., DRAGALIN I., ZINICOVSCAIA I., YUSHIN N., GROZDOV D., POPESCU V. Determination of the elemental composition of aromatic plants cultivated industrially in the Republic of Moldova using neutron activation analysis. In: Agronomy, 2021, 11(5), 1011-1030. https://doi.org/10.3390/agronomy11051011 (FI 3.7).
22. LUNGU, L., CUCICOVA, C., BLAJA, S., CIOCARLAN,  A., DRAGALIN,  I., VORNICU,  N., GEANA, E., MANGALAGIU, I.I., ARICU, A. Synthesis of homodrimane sesquiterpenoids bearing 1,3-benzothiazole unit and their Antimicrobial activity evaluation. In: Molecules, 2022, 27, 5082-5096. https://doi.org/10.3390/molecules27165082 (FI 4.6).
23. CIOCARLAN, A., DRAGALIN, I., ARICU, A., LUPASCU, L., CIOCARLAN, N., VERGEL, K., DULIU, O.G., HRISTOZOVA, G., ZINICOVSCAIA, I. Chemical profile, elemental composition, and antimicrobial activity of plants of the Teucrium (Lamiaceae) genus growing in Moldova. In: Agronomy, 2022, 12(4), 772-788. https://doi.org/10.3390/agronomy12040772 (FI 3.7).
24. CIOCARLAN, A. From (-)-sclareol to norlabdane heterocyclic hybrid compounds. In: Chemistry Journal of Moldova, 2022, 17(2), 30-45. http://dx.doi.org/10.19261/cjm.2022.958.
25. GIRBU, V., ORGAN, A., GRINCO, M., COTELEA, T., UNGUR, N., BARBA, A., KULCITKI, V. Identification, Quantitative Determination and Isolation of Pomolic Acid from Lavender (Lavandula Angustifolia Mill.) Wastes. In: Sustainable Chemistry and Pharmacy, 2023, 33, 101140. https://doi.org/10.1016/j.scp.2023.101140 (FI 6.0).
26. BLAJA S., LUNGU L., CIOCARLAN A., VORNICU N., ARICU A. Synthesis and evaluation of antimicrobial activity of tetranorlabdane compounds bearing 1,3,4-thiadiazole units. In: Chemistry Journal of Moldova, 2023, 18(1), 86-91.   https://doi.org/10.19261/cjm.2022.1026.
27. LUNGU, L, BLAJA, S., CUCICOVA, C., CIOCARLAN, A., BARBA, A., KULCIȚKI, V. SHOVA, S., VORNICU, N., GEANA, E.-I., MANGALAGIU, I.I., ARICU, A. Synthesis and antimicrobial activity evaluation of homodrimane sesquiterpenoids with benzimidazole unit. In: Molecules, 2023, 28(3), 933, 1-14. https://doi.org/10.3390/molecules28030933 (FI 4.6).
28. GRINCO, M., MORARESCU, O., LEMBO, F., UNGUR, N., TURCO, L., CORETTI, L., CARBONE, M., CELENTANO, C., CIAVATTA, M. L., MOLLO, E., KULCITKI, V., BUOMMINO, E. Synthesis and antimicrobial properties of guanidine-functionalized labdane type diterpenoids. In: European Journal of Medicinal Chemistry, 2024, 264, 115981. https://doi.org/10.1016/j.ejmech.2023.115981 (FI 6.7).

Articles in national journals

1. DUCA, GH., ARÎCU, A., KULCIȚKI, V., LUNGU, L. The happy road of knowledge. In: Chemistry Journal of Moldova, 2024, vol. 19(1), pp. 7-8. http://cjm.ichem.md/sites/default/files/ChemJMold_10.19261cjm.2024.1208-Editorial..pdf
2. KULCIŢKI, V., CIOCÂRLAN, A. Pe vârful de lance al cercetării mondiale. Membrul corespondent al AȘM Nicon UNGUR la 70 de ani. În: Revista de Ştiinţă, Inovare, Cultură şi Artă „Akademos”, 2024, 73(2), 175-176. https://ibn.idsi.md/vizualizare_articol/209324
3. COJOCARU-TOMA, M., ANCUCEANU, R., DINU, M., CIOBANU, N., CIOBANU, C., COTELEA, T., JIAN, M., COBZAC, V., NACU, V., TOMA, M. M. Viability and cytotoxicity evaluation on isolated hepatocytes of some species rich in polyphenolic compounds. In: Advansed Nano-Bio Materials and Devices –AdvNanoBioM&D, 2020, 4(2), 580-585. ISSN: 2559-1118
4. DRAGALIN, I., MELNIC, V., PELEAH, E. Polichimismul intraspecific mentha spicata. In: Studia Universitatis Moldaviae. Seria Ştiinţe reale şi ale naturii. 2020, 6 (136), 60-63. https://doi.org/10.5281/zenodo.4431568. IBN: https://ibn.idsi.md/ro/vizualizare_articol/120149
5. ORGAN, A., GÎRBU, V., COJOCARU-TOMA, M., KULCIŢKI, V., COTELEA T., UNGUR, N. Therapeutic potential and preventive effects of major triterpenic secondary metabolites from Lavandula angustifolia. In: Revista Farmaceutică a Moldovei, 2021, 45(1), 79-81. IBN: https://ibn.idsi.md/ro/vizualizare_articol/138710

Abstracts

1. BLAJA S., VICOL C., LUNGU L., CIOCARLAN A., ARICU A. Antioxidant activity of local lavender, clary sage, and coriander essential oils. In: Book of Abstracts of the National Conference of Chemistry, XXXVII Edition, Targoviste, Romania, 25-27 September 2024, OBFC_P6.
2. CIOCARLAN A., ARICU A., LUNGU L., BLAJA S., DRAGALIN I., LUPASCU L., CALUGĂRU-SPATARU T., POPESCU V. Chemical composition and assessment of antimicrobial activity of essential oil from different rose (Rosa damascena Mill.) cultivars. In: Book of Abstracts of the National Conference of Chemistry, XXXVII Edition, Targoviste, Romania, 25-27 September 2024, OBFC_P15.
3. BÎRCĂ, N., ORGAN, A., GÎRBU, V., BARBĂ, A., NICOLESCU, A., DELEANU, C., KULCIȚKI, V. Simultaneous quantitative determination of rosmarinic, oleanolic and ursolic acids in salvia glutinosa extracts by qnmr spectroscopy. In: Book of Abstracts of the National Conference of Chemistry, XXXVII Edition, Targoviste, Romania, 25-27 September 2024, OBFC_P12.
4. HARIZ, D., CHEN, D., DUDUIANU, C., BALAN-PORCARASU, M., MACSIM, A.M., AILIESEI, G.L., CRISTEA, M., STAVARACHE, C., STAN, R., USURELU, N., KULCITKI, V., NICOLESCU, A., DELEANU, C. Assessment of reproducibility in NMR metabolomics. In: Book of Abstracts of the National Conference of Chemistry, XXXVII Edition, Targoviste, Romania, 25-27 September 2024, Oral Communications in Parallel Sections.
5. CARPENCOV, S., KULCIȚKI, V. Docking and admdet studies of cytotoxic ent-kauranic derivatives. In: 23rd Romanian international conference on chemistry and chemical engineering, Constanța - Mamaia, Romania, 4-7 September 2024, S5-P-171.
6. BÎRCĂ, N., ORGAN, A., GÎRBU, V., BARBĂ, A., NICOLESCU, A., DELEANU, C., KULCIȚKI, V. Simultaneous determination of ursolic, pomolic, oleanolic and rosmarinic acids in lavender extracts. comparison of qNMR and HPLC data. In: Book of Abstracts of the National Conference of Chemistry, XXXVII Edition, Targoviste, Romania, 25-27 September 2024, oral presentation, section 5 Pharmaceutical Engineering & Food Safety, S5-O-ID169.
7. MUNTYAN E., CIOCARLAN A., KULCIŢKI V., BATCO M., ARICU A., LUNGU L., BLAJA S., POPESCU V. Effect of some essential oils on Acanthoscelides obtectus Say (coleoptera: bruchidae) and Tetranychus urticae koch, (acari: tetranychidae) adults. In: Conferința "Genetica, fiziologia şi ameliorarea plantelor", Chişinău, Moldova, 7-8 octombrie 2024, pp. 623-628. https://ibn.idsi.md/vizualizare_articol/213651

Patents

1. CIOCARLAN A., POPESCU V., LUPAȘCU L., DRAGALIN I., LUNGU L., BLAJA S., ARICU A. Forma oxidată a uleiului volatil de coriandru cu proprietăți antifungice și antibacteriene. Brvet de invenție MD 4904 B1 din 2024.10.31. https://www.db.agepi.md/Inventions/details/a%202023%200004/LinkTitluAcc
2. KULCITKI, V., UNGUR, N., GRINCO, M., BUOMMINO, E., LEMBO, F. Utilizarea ent-gomeroilguanidinei și ent-13-epigomeroilguanidinei în calitate de compuși cu proprietăți antimicrobiene și efect sinergistic în terapia combinată. Brvet de invenție MD 4893 B1 din 2024.05.31. https://www.db.agepi.md/Inventions/details/a%202022%200050/LinkTitluAcc
3. LUNGU L., CIOCARLAN A., CUCICOVA C., BLAJA S., ARICU A., VORNICU N. N-(2-Aminofenil)-8a-acetoxi-homodrimacetamidă cu proprietăţi antifungice şi antibacteriene. Brvet de invenție MD 4891 C1 din 2024.11.30. https://www.db.agepi.md/Inventions/details/a%202022%200060/LinkTitluElib
4. LUNGU L., CIOCARLAN A., CUCICOVA C., BLAJA S., ARICU A., VORNICU N. 2-Amino-1-∆8,9-biciclohomofarnesenoil)-benzimidazol pentru utilizare în tratamentul afecțiunilor provocate de fungi și bacterii. Brvet de invenție MD 4878 C1 din 2024.07.31. https://www.db.agepi.md/Inventions/details/a%202022%200029/LinkTitluElib
5. KULCIŢKI, V., GIRBU, V., PRUTEANU, E., RENAUD, PH., DAELEMANS, D., MOLLO, E., DEFRANOUX, F., UNGUR, N. Metil ent-17-amino-kauran-19-oat cu activitate citotoxică selectivă. Brevet de invenție MD 4718 B1. In: BOPI, 10/2020, p. 47-48. http://agepi.gov.md/ro/bopi/10-2020.
6. ARÎCU, A., CIOCARLAN, A., LUNGU, L., BLAJA, S., VORNICU, N.  5-(Homodrim-6,8-dien-11-il)-1,3,4-tiadiazol-2(3 H )-imină cu proprietăţi antifungice. Brevet de invenție 4765 B1, In: BOPI, 08/2021, p. 58-59. http://agepi.gov.md/sites/default/files/bopi/BOPI_08_2021.pdf

6. ARÎCU, A., CIOCÂRLAN,  A.,  LUNGU, L., BLAJA, S., VORNICU, N. (Z/E )-2-(1-((1R,2R,8aS)-2-hidroxi-2,5,5,8a-tetrametildecahidronaftalen-1-il)propan-2-iliden)hidrazincarbotioamidă pentru utilizare în calitate de remediu antifungic. Brevet de invenție 4769. B1. In: BOPI, 10/2021, p. 44-45. http://agepi.gov.md/sites/default/files/bopi/BOPI_10_2021.pdf 
7. KULCIŢKI, V., GIRBU, V., PRUTEANU, E., RENAUD, PH., DAELEMANS, D., UNGUR, N. Metil ent-15-hidroxi-16-azido-17-carboximetoximetilkauranoat cu activitate citotoxică selectivă. Brevet de invenție MD4785 (13) B1. In: BOPI, 2022, (1), p. 47-48. https://www.agepi.gov.md/sites/default/files/bopi/BOPI_01_2022.pdf#page=7.
8. KULCIŢKI V., GÎRBU V., PRUTEANU E., RENAUD P., DAELEMAS D., UNGUR N. Noi spiro γ-lactame, derivate ale acidului ent-kaurenoic, cu activitate citotoxică selectivă. Brevet de invenție MD4786 (13) B1. In: BOPI, 2022, (1), p. 48-49. https://www.agepi.gov.md/sites/default/files/bopi/BOPI_01_2022.pdf#page=7.
9. KULCIŢKI, V., GIRBU, V., PRUTEANU, E., RENAUD, PH., DAELEMANS, D., UNGUR, N. Ester metilic al acidului (16R)-spiro[pirolidin-2´, 16-ent-17-norkauran]-19-oic cu activitate citotoxică selectivă. Brevet de invenție MD4792 (13) B1. In: BOPI, 2022, (2), p. 57-58. https://www.agepi.gov.md/sites/default/files/bopi/BOPI_02_2022.pdf#page=7.
10. KULCIŢKI, V., GIRBU, V., PRUTEANU, E., RENAUD, PH., DAELEMANS, D., UNGUR, N. Utilizarea metil ent-16-azido-17-carboxietoximetilkauranoatului în calitate de inhibitor selectiv al proliferării limfomului non-Hodgkin. Brevet de invenție MD4805 (13) B1. In: BOPI, 2022, (5), p. 55-56.
    https://www.agepi.gov.md/sites/default/files/bopi/BOPI_05_2022.pdf#page=7.