Laboratory of Chemistry of Natural and Biologically Active Compounds

Manuals, chapters in monographs

1. ARÎCU, A., KULCIȚKI, V., UNGUR, N. Sclareolul - Materie Primă Sustenabilă Pentru Sinteza Compușilor Terpenici cu Valoare Adăugată Înaltă. În: Chimie Ecologică: Istorie și Realizări. Academicianul Gheorghe Duca, 70 Ani de la Naștere. Chișinău, 2022, pp. 86-114. ISBN 978-9975-159-05-0.
2. ARÎCU, A., LUNGU, L., BLAJA, S., CUCICOVA, C., CIOCÂRLAN, A. Sinteza și Studiul Activității Antimicrobiene a Compușilor Norlabdanici cu Unități Structurale Heterociclice. In: Acad. A. Gulea - Conferinţa Ştiinţifică Naţională cu participare Internaţională: „Materiale Avansate în Biofarmaceutică şi Tehnică”, Culegere de articole, Chişnău, 2021, p. 10-34.
3. UNGUR, N.; MORARESCU, O. Sinteza Dirijată a Unor Diterpenoide Tetraciclice Bioactive din Acidul ent-Kaur-16-en-19-oic”. In: Acad. A. Gulea - Conferinţa Ştiinţifică Naţională cu participare Internaţională: „Materiale Avansate în Biofarmaceutică şi Tehnică”, Culegere de articole, Chişnău, 2021, 294-313.
4. KULCIȚKI, V. Strategia Sintezei Organice. Principii Generale și Noțiuni Fundamentale. Suport de curs. USDC, Chișinău, 2020. ISBN 978-9975-89-164-6. 94 p.
5. KULCIȚKI, V. Istoria și Evoluția Cercetării în Chimie. Suport de curs. USDC, Chișinău, 2019. ISBN 978-9975-108-98-0. 114 p.
6. ARICU, A.; UNGUR, N.; DUCA, Gh. Design, Targeted Synthesis and Study of Biological Activity of Some Polifunctional Chiral Terpenic Compounds. In: Compounds and materials for drug development and biomedical applications, Resp. ed. Gh G. Duca, F. Z. Macaev, Editura Academiei Române; Editura Istros a Muzeului Brăilei „Carol I”, 2018, pp. 101-126. ISBN 978-973-27-2944-1.
7. UNGUR, N.; ARÎCU, A.; GRINCO, M. Occurrence, Biological Activity and Synthesis of Diterpenoid Amides. In: Diterpenoids. Types, Functions and Research. Brandon Jones Ed., Nova Science Publishers, Inc., New York, 2017, pp. 1-38. ISBN 9781536106718.

Articles

1. CIOCARLAN, A., DRAGALIN, I., ARICU, A., LUPASCU, L., CIOCARLAN, N., VERGEL, K., DULIU, O.G., HRISTOZOVA, G., ZINICOVSCAIA, I. Chemical profile, elemental composition, and antimicrobial activity of plants of the Teucrium (Lamiaceae) genus growing in Moldova. In: Agronomy, 2022, 12(4), 772-788. (FI 2.24). DOI: https://doi.org/10.3390/agronomy12040772
2. CIOCARLAN, A., LUPASCU, L., ARICU, A., DRAGALIN, I., POPESCU, V., GEANA, E.I., IONETE, R.E., VORNICU, N., DULIU, O.G., HRISTOZOVA, G., ZINICOVSCAIA, I. Chemical composition and assessment of antimicrobial activity of lavender essential oil and some by-products. In: Plants, 2021, 10(9), 1829-1843. (FI 3.935). DOI: https://doi.org/10,3390/plants1091829.
3. URECHE, D., BULHAC, I., CIOCARLAN, A., ROSHCA, D., LUPASCU, L., BOUROSH, P. Novel vic-Dioximes: synthesis, structure characterization and antimicrobial activity evaluation. In: Turkish Journal of Chemistry, 2021, 45(6), 1873-1881. (FI 1.239). DOI: 10.3906/kim-2104-24
4. CIOCARLAN, A., HRISTOZOVA, G., ARICU, A., DRAGALIN, I., ZINICOVSCAIA, I., YUSHIN, N., GROZDOV D., POPESCU, V. Determination of the elemental composition of aromatic plants cultivated industrially in the Republic of Moldova using neutron activation analysis. In: Agronomy, 2021, 11(5), 1011-1030. (FI 2.603) DOI: 10.3390/agronomy11051011
5. GEANĂ, E.-I., CIUCURE, C.T., IONETE, R.E., CIOCARLAN, A., ARICU, A., FICAI, A., ANDRONESCU, E. Profiling of phenolic compounds and triterpene acids in different apple (Malus domestica Borkh.) cultivars. In: Foods, 2021, 10(2), 267-282. (FI 4.350). DOI: https://doi.org/10.3390/foods10020267
6. BLAJA, S.P., LUNGU, L.V., KUCHKOVA, K.I., CIOCARLAN, A.G., BARBA, A.N., VORNICU, N., ARICU, A.N. Norlabdane compounds containing thiosemicarbazone or 1,3-thiazole fragments: Synthesis and antimicrobial activity. In: Chemistry of Natural Compounds, 2021, 57(1), 101-110. (FI 0.809).  DOI: https://doi.org/10.1007/s10600-021-03292-3
7. CIOCARLAN, A., LUPASCU, L., ARICU, A., DRAGALIN, I., CIOCARLAN, N., ZINICOVSCAIA, I., SLANINA, V., YUSHIN, N. Chemical composition of the essential oil and antimicrobial properties of crude extract from Tanacetum corymbosum (L.). In: Chemistry Journal of Moldova, 2021, 16(2), 83-90.  DOI: 10.19261/cjm.2021.877
8. CIOCARLAN, A. (+)-Larixol and larixyl acetate: syntheses, phytochemical studies and biological activity assessments. In: Chemistry Journal of Moldova. 2021, 16, (1), pp. 30-45.  DOI: https://doi.org/10.19261/cjm.2021.836
9. MORARESCU, O.; GRINCO, M.; KULCIŢKI, V.; BARBA, A.; GARBUZ, O.; GULEA, A. and UNGUR, N. Synthesis of Highly Functionalized Biologically Active Tetracyclic Diterpenoids from ent-Kaur-16-en-19-oic Acid under Modified Prévost-Woodward Reaction Conditions. In: Russ. J. Org. Chem., 2021,  57, 1931–1939. (FI 0.723) DOI: 10.1134/S1070428021120058.
10. MORARESCU, O., GRINCO, M., KULCIŢKI, V., SHOVA, S., UNGUR, N. An Alternative Approach towards C-12 Functionalized Scalaranic Sesterterpenoids. Synthesis of 17-Oxo-20-norscalaran-12α,19-O-lactone. In: Marine Drugs, 2021, 19(11), 636. (FI 5.118) DOI: 10.3390/md19110636.
11. PRUTEANU, E., GÎRBU, V., UNGUR, N., PERSOONS, L., DAELEMANS, D., RENAUD, P. and KULCIȚKI, V. Preparation of Antiproliferative Terpene-Alkaloid Hybrids by Free Radical-Mediated Modification of ent-Kauranic Derivatives. In: Molecules, 2021, 26(15), pp. 4549-4568. (FI 4.412) DOI: 10.3390/molecules26154549.
12. ORGAN, A.; GÎRBU, V.; COJOCARU-TOMA, M.; KULCIŢKI, V.; COTELEA T.; UNGUR, N. Therapeutic potential and preventive effects of major triterpenic secondary metabolites from Lavandula angustifolia. In: Revista Farmaceutică a Moldovei, 2021, 45(1), 79-81.
13. MORARESCU, O., TRAISTARI, M., BARBA, A., DUCA, G., UNGUR, N. and KULCIȚKI, V. One-step selective synthesis of 13-epi-manoyl oxide. In: Chem.J.Mold., 2021, 16 (1), pp. 99-104.  DOI: http://dx.doi.org/10.19261/cjm.2021.820.
14. PRUTEANU, E.; TAPPIN, N.D.; GÎRBU, V.; MORARESCU, O.; DÉNÈS, F.; KULCIŢKI, V. and RENAUD, P. Forskolin Editing via Radical Iodo-and Hydroalkylation. In: Synthesis, 2021, 53(07), pp. 1247-1261. (FI 3.157)  DOI: 10.1055/s-0040-1706003.
15. MORARESCU, O.; GRINCO, M.; KULCIŢKI, V.; BARBA, A.; GARBUZ, O.; GUDUMAC, V.; GULEA, A. and UNGUR, N. A Straightforward Synthesis of Natural Oxygenated ent-Kaurenoic Acid Derivatives. In: Synthetic Communications, 2021, 51(1), pp. 123-133. (FI 2.007). DOI: 10.1080/00397911.2020.1821225.
16. D.Ia.Bilan, N.S.Sucman, O.M.Radul, I.P,Dragalin, A.N.Barba, F.Z.Macaev,       Sintez proizvodnîh (-)-ConvolutamidinaA i analogov. In: Himia prirodnîh soedinenii, 2021,  Nr. 3, pp.440-443. (FI 0.809).
17. ARICU, A. N., KUCHKOVA, K. I., SECARA-CUSHNIR, E. S., BARBA, A. N., UNGUR, N. D., VORNICU, N. Synthesis and Antimicrobial Activity of New Drimane and Homodrimane Sesquiterpenoids with Oxadiazole and Thiadiazole Fragments. In: Chemistry of Natural Compounds. 2020, nr. 4(56), pp. 656-662. (FI 0.809).   DOI: https://doi.org/10.1007/s10600-020-03115-x
18. LUNGU, L., CIOCARLAN, A., SMIGON, C., OZER, I., SHOVA, S., GUTU, I., VORNICU, N., MANGALAGIU, I., D'AMBROSIO, M., ARICU, A.. Synthesis and evaluation of biological activity of homodrimane sesquiterpenoids bearing 1,3,4-oxadiazole or 1,3,4-thiadiazole units. In: Chemistry of Heterocyclic Compounds, 2020, 56(5), 578-585. (FI 1.492). DOI: 10.1007/s10593-019-02526-1.
19. ZINICOVSCAIA, I., GUNDORINA, S., VERGEL, K., GROZDOV, D., CIOCARLAN, A., ARICU, A., DRAGALIN, I., CIOCARLAN, N. Elemental analysis of Lamiaceae medicinal and aromatic plants growing in the Republic of Moldova using neutron activation analysis. In: Phytochemistry Letters, 2020, 35, 119-127. (FI 1.338). DOI: 10.1016/j.phytol.2019.10.009
20. CIOCARLAN, A., LUNGU, L., BLAJA, S., DRAGALIN, I., ARICU, A. The use of some non-conventional methods in chemistry of bicyclohomofarnesenic methyl esters. In: Chemistry Journal of Moldova, 2020, 15(2), 69-77. DOI: https://doi.org/10.19261/cjm.2020.791.
21. ELENA PELEAH, VICTOR MELNIC, ION DRAGALIN. Polichimismul intraspecific Mentha spicata. In: Studia Universitatis Moldaviae, 2020, 6 (136), pp. 60-63.
22. INGA ZINICOVSCAIA ALEXANDRU CIOCARLAN, LUCIAN LUPASCU, ACULINA ARICU, ION DRAGALIN, NINA CIOCARLAN & NIKITA YUSHIN. Chemical analysis of Tanacetum corymbosum (L.) Sch. Bip. uising neutron activation. In: Journal of Radioanalitical and Nuclear Chemistry, 2019, 321 (2), pp. 349-354. (FI 0.983).  DOI: 10.1007/s10967-019-06590-x
23. LUNGU, LIDIA; CIOCARLAN, ALEXANDRU; BARBĂ, ALIC; SHOVA, SERGIU; POGREBNOI, SERGHEI; MANGALAGIU, IONEL; MOLDOVEANU, COSTEL; VORNICU, NICOLETA; AMBROSIO, MICHELE; BABAK, MARIA V.; ARION, VLADIMIR; ARICU, ACULINA. Synthesis and Evaluation of Biological Activity of Homodrimane Sesquiterpenoids Bearing Hydrazinecarbothioamide or 1,2,4-Triazole Unit. In: Chemistry of Heterocyclic Compounds. 2019, 55(8), pp. 716-724. ISSN 0009-3122.  DOI: 10.1007/s10593-019-02526-1.
24. ARICU, ACULINA; NASTAS, RAISA; COCU, MARIA. The institute of chemistry at 60 years anniversary. brief history, achievements and perspectives. In: Chemistry Journal of Moldova. 2019, nr. 1(14), pp. 8-31. ISSN 1857-1727. DOI: 10.19261/cjm.2019.349.
25. SÎRBU, T.; GIRBU, V.; HARGHEL, P.; RUSU, V.; UNGUR, N. and KULCIŢKI, V. Selectivity Control in Terpene Rearrangements: A Biomimetic Synthesis of the Halimanic Bicyclic Core. In: Synthesis, 2019, 51(09), pp. 1995-2000. (FI 3.157). DOI: 10.1055/s-0037-1610686.
26. DUCA, Gh.; ARICU, A.; KUCHKOVA, K.; SECARA, E.; BARBA, A.; DRAGALIN, I.; UNGUR, N.; SPENGLER, G. Synthesis and Anticancer Activity of New Guanidine - Containing Diterpenoids. In: Nat. Prod. Res., 2019, 33 (21), 3052-3056. (FI 1.928). DOI: 10.1080/14786419.2018.1516658
27. DUCA GH., ARICU A., LUNGU L., TENU N., CIOCARLAN A., GUTU Y., DRAGALIN I., BARBA A. Synthesis of new homodrimane sesquiterpenoids containing diazine, 1,2,4-triazole and carbazole rings. In: Chem. J. Mold., 2018, vol. 13, nr.1, p. 69-73. DOI:http://dx.doi.org/10.19261/cjm.2017.458.
28. CIOCARLAN A., DRAGALIN I., ARICU A., CIOCARLAN N., STAVARACHE C., M. DELEANU. Chromatographic analysis of Silybum Marianum (L.) Gaertn. Fatty oil. In: Chem. J. of Moldova, 2018, vol. 13, nr. 1, p. 63-68.  DOI: http://dx.doi.org/10.19261/cjm.2018.484 .
29. ALEXANDRU CIOCARLAN, ION DRAGALIN, ACULINA ARICU, LUCIAN LUPASCU, NINA CIOCARLAN, VIOLETA POPESCU. Chemical composition and antimicrobial activity of the Levisticum officinale W.D.J. Koch essential oil. In: Chem. J. Mold, 2018, 13(2), 63-68.  DOI: http://dx.doi.org/10.19261/cjm.2018.514
30. MICHELE D'AMBROSIO, ALEXANDRU CIOCARLAN, ACULINA ARICU. Minor acetylated metabolites from Euphrasia rostkoviana. Natural and synthetic acetylated derivatives of rutin. In: Nat. Prod. Res., 2018, 34(2), 290. (FI 1.928). DOI: https://doi.org/10.1080/14786419.2018.1530227.
31. ARICU, A. N.; KUCHKOVA, K. I.; SECARA, E. S.; BARBA, A. N.; DRAGALIN, I. P.; UNGUR, N. D.; MELNIK, E.; KRAVTSOV, V. Kh. Synthesis and Structure of Drimane Sesquiterpenoids Containing Pyrimidine, Pyrazine, 1,2,4-triazole, and Carbazole Rings. In: Chem.Nat. Comp., 2018, 54 (3), 455-460. (FI 0.509).  DOI: https://doi.org/10.1007/s10600-018-2378-z
32. CARBONE, M.; CIAVATTA, M. L.; MATHIEU, V.; INGELS, A.; KISS, R.; PASCALE, P.; MOLLO, E.; UNGUR, N.; GUO, Y.-W.; GAVAGNIN, M. Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues. In: J. Nat. Prod., 2017, 80 (5), 1339-1346. (FI 3.885). DOI: https://doi.org/10.1021/acs.jnatprod.6b00941
33. CIOCARLAN A., ARICU A., LUNGU L., EDU C., BARBA A., SHOVA S., MANGALAGIU I. I., D’AMBROSIO M., NICOLESCU A., DELEANU C., VORNICU N. Synthesis of novel tetranorlabdane derivatives with unprecedented carbon skeleton. In: Synlett, 2017, vol. 28, nr, 05, p. 565–571. (FI 2.32). DOI: 10.1055/s-0036-1588651. ISSN 1437-2096

Patents

1. KULCIŢKI, V., GIRBU, V., PRUTEANU, E., RENAUD, PH., DAELEMANS, D., UNGUR, N. New Spiro-g-Lactams, ent-Kaurenoic Acid Derivatives, with Selective Cytotoxic Activity. Patent Nr  4786 (13) B1, BOPI, 2022, (1), pp. 49.
2. KULCIŢKI, V., GIRBU, V., PRUTEANU, E., RENAUD, PH., DAELEMANS, D., UNGUR, N. Methyl ent-15-hydroxy-16-azido-17-carboxymethoxymethylkauranoate with Selective Cytotoxic Activity. Patent Nr  4785 (13) B1, BOPI, 2022, (1), pp. 47-48.
3. KULCIŢKI, V., GIRBU, V., PRUTEANU, E., RENAUD, PH., DAELEMANS, D., UNGUR, N. (16R)-Spiro[pyrrolidine-2´,16-ent-17-norkauran]-19-oic Acid Methyl Ester with Selective Cytotoxic Activity. Patent Nr  4792 (13) B1, BOPI, 2022, (2), pp. 57-58.
4. ARÎCU, A., CIOCÂRLAN, A., LUNGU, L., BLAJA, S., VORNICU, N. (Z/E)-2-(1-((1R,2R,8aS)-2-hidroxi-2,5,5,8a-tetrametildecahidronaftalen-1-il)propan-2-iliden)hidra- zincarbotioamidă pentru utilizare în calitate de remediu antifungic. Patent MD 4769.
5. ARÎCU, A., CIOCÂRLAN, A., LUNGU, L., BLAJA, S., VORNICU, N. 5-(Homodrim-6,8-dien-11-il)-1,3,4-tiadiazol-2(3H)-imină cu proprietăţi antifungice. Patent MD 4765.
6. KULCIŢKI, V.; GÎRBU, V.; PRUTEANU, E.; RENAUD, P.; DAELEMAS, D.; MOLLO, E.; DEFRANOUX, F.; UNGUR, N. Methyl ent-17-amino-kauran-19-oate with Selective Cytotoxic Activity. Patent Nr  4718 (13) B1, BOPI, 2020, (10), pp. 47-48.
7. ARÎCU, A.; KUCHKOVA, K.; DUCA, GH.; SECARA, E.; BARBA, A.; DRAGALIN, I.; UNGUR, N. Compusul 1-(4-((4aS,8aS)-2,5,5,8a-tetrametil-3,4,4a,5,6,7,8,8a-octahidronaftalen1-il)butan-2-il)guanidină cu activitate antiproliferativă şi citotoxică. Patent Nr. 4630, MD, BOPI, 2019, (5), p.41.
8. ARÎCU, A.; KUCHKOVA, K.; DUCA, GH.; SECARA, E.; BARBA, A.; DRAGALIN, I.; UNGUR, N. Compusul N-carbamimidoil-2-((8aS)-2,5,5, 8a-tetrametil-3,4,4a,5,6,7,8,8aoctahidronaftalen-1-il)acetamidă cu activitate antiproliferativă şi citotoxică. Patent Nr. 4631, MD, BOPI, 2019, (5), p.41-42.
9. ARÎCU ACULINA, LUNGU LIDIA, CIOCARLAN ALEXANDRU, VORNICU NICOLETA. Compus (1R,2R,8aS)-1-((5-mercapto-1,3,4-thiadiazol-2-il)metil)-2,5,5,8atetrametildecahidro nafthalen-2-ol cu proprietăţi antifungice şi antibacteriene. Patent Nr. 4580 C1, 28.02.2019, MD,  BOPI 1/2019.
10. ARÎCU, A.; KUCHKOVA, K.; SECARA, E.; BARBA, A.; DRAGALIN, I.; UNGUR, N. Compusul 13-amino-14,15-dinorlabd-8(9)-enă pentru utilizare în calitate de remediu antimicotic. Patent Nr. 4573, MD, BOPI, 2018, (6).
11. ROBU, Ș.; PRISACARI, V.; KULCIȚKI, V.; GRINCO, M.; BARBA, A. Polymeric Material with Antibacterial Properties Based on Lignin Grafted with N'-(5-nitrofurfurylidene) isonicotinehydrazide. Patent Nr 4506, BOPI, 2017, (8), p. 29.