Laboratory of Chemistry of Natural and Biologically Active Compounds

poza

 

Head of the laboratory 
dr. habilitate, assoc. prof. Veaceslav KULCIȚKI

 

Office:  309
Phone: (+373 22) 73 99 92
Email: veaceslav.kulcitki @ sti.usm.md
kulcitki @ yahoo.com
veaceslav.kulcitki @ ichem.md

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Short history

The Laboratory Chemistry of Natural Compounds was founded in 1959 and headed then by acad. Gheorghe Lazurievski. The research activity developed fruitfully and the laboratory expanded significantly by several independent research groups, covering different areas of natural product chemistry. Consequently, it was divided in 1976 into three separate laboratories: Chemistry of Steroidal Compounds (headed by dr. Petru Ceban), Chemistry of Isoprenoids (headed by dr. Dumitru Popa) and Chemistry of Ethereal-Oleaginous Plants (headed by acad. Pavel Vlad).

Later on, after several structural changes, two of these laboratories merged in 1991 into the Laboratory of Terpenoid Chemistry (headed by acad. Pavel Vlad). Then, the laboratory was renamed into the Laboratory of Chemistry of Natural and Biologically Active Compounds (2016).

Research areas
  • Targeted synthesis of polifunctionalized bioactive terpenic compounds;
  • Elaboration of methods for renewable resources valorization;
  • Elaboration   of    new   green   methods   for   the modification of natural products.
Staff
Recent publications
Research projects
Noutăți
Veaceslav KULCITKI
dr. habilitate, assoc.prof.
Head of the laboratory
office 309
Phone: (+373 22) 73 97 75
email: veaceslav.kulcitki @ sti.usm.mdkulcitki @ yahoo.com,
veaceslav.kulcitki @ ichem.md
Nicon UNGUR
dr. habilitate, assoc.prof.
Principal scientific researcher
office  301
phone: (+373 22) 73 97 75
email: nicon.ungur @ sti.usm.mdnicon.ungur @ gmail.com, 
nicon.ungur @ ichem.md
Aculina ARICU
dr. habilitate, assoc. prof.
Principal scientific researcher
birou  308
tel.: (+373 22) 72 71 23
email:  aculina.aricu @ sti.usm.mdaculina.aricu @ gmail.com
aculina.aricu @ ichem.md
Ion DRAGALIN
dr.  assoc. prof.
Leading scientific researcher
office  306
phone: (+373 22) 73 97 69
email: ion.dragalin @ sti.usm.mdiondragalin @ yahoo.com,
ion.dragalin @ ichem.md
Alexandru CIOCARLAN
dr.  conf. cerc.
Leading scientific researcher
office  304
phone: (+373 22) 73 97 69
email:  alexandru.ciocarlan @ sti.usm.mdalgciocarlan @ yahoo.com, alexandru.ciocarlan @ ichem.md
Marina GRINCO
dr.  conf. cerc.
Leading scientific researcher
office  310
phone: (+373 22) 73 97 69
email: marina.grinco @ sti.usm.mdgrinkom @ yahoo.com, marina.grinco @ ichem.md
Lidia LUNGU
dr. 
Senior scientific researcher
office  307
phone: (+373 22) 73 97 69
email:  lidia.lungu @ sti.usm.mdlidilungu @ yahoo.com, 
lidia.lungu @ ichem.md
Elena SECARĂ-KUȘNIR
dr. 
Scientific researcher
office  318
phone: (+373 22) 73 97 69
email:  elena.secara-kusnir @ sti.usm.mdesecara8 @ gmail.com, 
elena.secara-kusnir @ ichem.md
Vladilena GIRBU
dr. 
Scientific researcher
office  304a
phone.: (+373 22) 73 97 69
email: vladilena.girbu @ sti.usm.mdvgirbu1 @ gmail.com, 
vladilena.girbu @ ichem.md
Alic BARBA
dr.
Leading scientific researcher
office 145
phone: (+373 22) 73 96 49
email: alic.barba @ sti.usm.md[email protected];  [email protected]
Svetlana BLAJA
dr.                                                                Scientific researcher
office  307
phone: (+373 22) 73 97 69
email: svetlana.blaja @ sti.usm.mdsvetlana-blaja @ mail.ru, 
svetlana.blaja @ ichem.md
Natalia Birca
Stagiar scientific researcher
office  317
phone: (+373 22) 73 97 69
email:  natalia.birca @ sti.usm.mdbirca.natalia96 @ gmail.com 

Chapters in international/national monographs

  1. ARICU, A., CIOCARLAN, A., LUNGU, L., CUCICOVA, C., BLAJA, S., SECARA, E., UNGUR N. Synthesis of Biologically Active Nitrogen and Sulfur-Containing Terpenoids. In: Fundamental and Biomedical Aspects of Redox Processes. IGI Global, 2023, 369-399.
  2. ARÎCU, A., KULCIŢKI, V., UNGUR, N. Sclareolul–materie primă sustenabilă pentru sinteza compușilor terpenici cu valoare adăugată înaltă. In: Chimie ecologică: istorie și realizări: Academicianul Gheorghe Duca, 70 ani de la naștere. Chişinău: 2022, 86-113. ISBN 978-9975-159-05-0. https://ibn.idsi.md/vizualizare_articol/164444.
  3. ARÎCU, A., LUNGU, L., BLAJA, S., CUCICOVA, C., CIOCÂRLAN, A. Sinteza și studiul activității antimicrobiene a compușilor norlabdanici cu unități structurale heterociclice. In: Acad. A. Gulea - Conferinţa Ştiinţifică Naţională cu participare Internaţională: „Materiale Avansate în Biofarmaceutică şi Tehnică”, Chişnău, 2021, 10-34.
  4. UNGUR, N., MORARESCU, O. Sinteza dirijată a unor diterpenoide tetraciclice bioactive din acidul ent-kaur-16-en-19-oic. In: Acad. A. Gulea - Conferinţa Ştiinţifică Naţională cu participare Internaţională: „Materiale Avansate în Biofarmaceutică şi Tehnică”, Chişnău, 2021, 294-313.


Articles in international journals

  1. ANTOCI, V., CUCU, D., ZBANCIOC, Gh., MOLDOVEANU, C., MANGALAGIU, V., AMARIUCAI-MANTU, D., ARICU, A, MANGALAGIU I. I. Bis-(imidazole/benzimidazole)-pyridine derivatives: synthesis, structure and antimycobacterial activity. In: Future Medicinal Chemistry, Part XII, 2020, 12(3), 207-222. https://doi.org/10.4155/fmc-2019-0063 (FI 4.2).
  2. MORARESCU, O., GRINCO, M., KULCIŢKI, V., BARBA, A., GARBUZ, O., GUDUMAC, V., GULEA, A., UNGUR, N. A straightforward synthesis of natural oxygenated ent-kaurenoic acid derivatives. In: Synthetic communications, 2020, 50. https://doi.org/10.1080/00397911.2020.1821225 (FI 2.1).
  3. ZINICOVSCAIA, I., GUNDORINA, S., VERGEL, C., GROZDOV, D., CIOCARLAN, A., ARICU, A., DRAGALIN, I., CIOCARLAN, N. Elemental analysis of Lamiaceae medicinal and aromatic plants growing in the Republic of Moldova using neutron activation analysis. In: Phytochemistry Letters. 2020, 35, 119–127. https://doi.org/10.1016/j.phytol.2019.10.009 (FI 1.7).
  4. LUNGU, L., CIOCARLAN, A., SMIGON, C., OZER, I., SHOVA, S., GUTU, I., VORNICU, N., MANGALAGIU, I., D'AMBROSIO, M., ARICU, A. Synthesis and evaluation of biological activity of homodrimane sesquiterpenoids bearing 1,3,4-oxadiazole or 1,3,4-thiadiazole units. In: Chemistry of Heterocyclic Compounds, 2020, 56(5), 578-585. https://doi.org/10.1007/s10593-020-02703-7 (FI 1.5).
  5. ARICU, A., KUCHKOVA, K., SECARA-CUSHNIR, E., BARBA, A., UNGUR, N., VORNICU, N. Synthesis and antimicrobial activity of new drimane and homodrinane sesquiterpenoids with oxadiazole and thiadiazole fragments. In: Chemistry of Natural Compounds, 2020, 56(4), 656-662. https://doi.org/10.1007/s10600-020-03115-x (FI 0.8).
  6. CIOCARLAN, A., LUNGU, L., BLAJA, S., DRAGALIN, I., ARICU, A. The use of some non-conventional methods in chemistry of bicyclohomofarnesenic methyl esters. In: Chemistry Journal of Moldova, 2020, 15(2), 69-77. https://doi.org/10.19261/cjm.2020.791. IBN: https://ibn.idsi.md/ro/vizualizare_articol/118145
  7. CIOCARLAN, A., LUPASCU, L., ARICU, A., DRAGALIN, I., POPESCU, V., GEANA, E.I., IONETE, R.E., VORNICU, N., DULIU, O.G., HRISTOZOVA, G. AND ZINICOVSCAIA, I. Chemical composition and assessment of antimicrobial activity of lavender essential oil and some by-products. In: Plants, 2021, 10(9), 1829.  https://doi.org/10,3390/plants1091829 (FI 4.5). IBN: https://ibn.idsi.md/ro/vizualizare_articol/138166
  8. PRUTEANU, E., GÎRBU, V., UNGUR, N., PERSOONS, L., DAELEMANS, D., RENAUD, P., KULCIȚKI, V. Preparation of antiproliferative terpene-alkaloid hybrids by free radical-mediated modification of ent-kauranic derivatives. In: Molecules, 2021, 26(15), 4549. https://doi.org/10.3390/molecules26154549 (FI 4.6).
  9. GEANĂ, E.-I., CIUCURE, C.T., IONETE, R.E., CIOCARLAN, A., ARICU, A., FICAI, A., ANDRONESCU, E. Profiling of phenolic compounds and triterpene acids in different apple (Malus domestica Borkh.) cultivars. In: Foods, 2021, 10(2), 267-282.  https://doi.org/10.3390/foods10020267 (FI 5.2).  IBN: https://ibn.idsi.md/ro/vizualizare_articol/126448
  10. MORARESCU, O., GRINCO, M., KULCIŢKI, V., SHOVA, S., UNGUR, N. An Alternative Approach towards C-12 Functionalized Scalaranic Sesterterpenoids. Synthesis of 17-Oxo-20-norscalaran-12α,19-O-lactone. In: Marine Drugs, 2021, 19(11), 636.  https://doi.org/10.3390/md19110636 (FI 5.4).
  11. PRUTEANU, E., TAPPIN, N.D., GÎRBU, V., MORARESCU, O., DÉNÈS, F., KULCIŢKI, V., RENAUD, P. Forskolin Editing via Radical Iodo-and Hydroalkylation. In: Synthesis, 2021, 53(07), 1247-1261. https://doi.org/10.1055/s-0040-1706003 (FI 2.6).  IBN: https://ibn.idsi.md/ro/vizualizare_articol/125941
  12. BLAJA, S.P., LUNGU, L.V., KUCHKOVA, K.I., CIOCARLAN, A.G., BARBA, A.N., VORNICU, N., ARICU, A.N. Norlabdane Compounds Containing Thiosemicarbazone or 1,3-Thiazole Fragments: Synthesis and Antimicrobial Activity. In: Chemistry of Natural Compounds, 2021, 57(1), 101-110. https://doi.org/10.1007/s10600-021-03292-3 (FI 0.8). IBN: https://ibn.idsi.md/ro/vizualizare_articol/126852
  13. ARÎCU, A. The natural product chemistry of terpenoids - a tribute to the remarkable legacy of academician Pavel Vlad. In: Chemistry Journal of Moldova. 2021, 16(1), 8-29. https://doi.org/10.19261/cjm.2021.856.  IBN: https://ibn.idsi.md/ro/vizualizare_articol/134250
  14. CIOCARLAN A., LUPASCU L., ARICU A., DRAGALIN I., CIOCARLAN N., ZINICOVSCAIA I., SLANINA V., YUSHIN N. Chemical composition of the essential oil and antimicrobial properties of crude extract from Tanacetum corymbosum (L.). In: Chemistry Journal of Moldova, 2021, 16(2), 83-90. https://doi.org/10.19261/cjm.2021.877.
  15. CIOCARLAN, A. (+)-Larixol and larixyl acetate: syntheses, phytochemical studies and biological activity assessments. In: Chemistry Journal of Moldova. 2021, 16(1), 30-45. https://doi.org/10.19261/cjm.2021.836 IBN: https://ibn.idsi.md/ro/vizualizare_articol/134251
  16. MORARESCU, O., TRAISTARI, M., BARBA, A., DUCA, G., UNGUR, N. AND KULCIȚKI, V. One-step selective synthesis of 13-epi-manoyl oxide. In: Chemistry Journal of Moldova, 2021, 16(1), 99-104. http://dx.doi.org/10.19261/cjm.2021.820.
  17. MORARESCU, O., GRINCO, M., KULCITKI, V. et al. Synthesis of highly functionalized biologically active tetracyclic diterpenoids from ent-kaur-16-en-19-oic acid under modified Prévost-Woodward reaction conditions. In: Russian Journal of Organic Chemistry, 2021, 57, 1931–1939. https://doi.org/10.1134/S1070428021120058 (FI 0.8).
  18. CIOCARLAN A., HRISTOZOVA G., ARICU A., DRAGALIN I., ZINICOVSCAIA I., YUSHIN N., GROZDOV D., POPESCU V. Determination of the elemental composition of aromatic plants cultivated industrially in the Republic of Moldova using neutron activation analysis. In: Agronomy, 2021, 11(5), 1011-1030. https://doi.org/10.3390/agronomy11051011 (FI 3.7).
  19. LUNGU, L., CUCICOVA, C., BLAJA, S., CIOCARLAN,  A., DRAGALIN,  I., VORNICU,  N., GEANA, E., MANGALAGIU, I.I., ARICU, A. Synthesis of homodrimane sesquiterpenoids bearing 1,3-benzothiazole unit and their Antimicrobial activity evaluation. In: Molecules, 2022, 27, 5082-5096. https://doi.org/10.3390/molecules27165082 (FI 4.6).
  20. CIOCARLAN, A., DRAGALIN, I., ARICU, A., LUPASCU, L., CIOCARLAN, N., VERGEL, K., DULIU, O.G., HRISTOZOVA, G., ZINICOVSCAIA, I. Chemical profile, elemental composition, and antimicrobial activity of plants of the Teucrium (Lamiaceae) genus growing in Moldova. In: Agronomy, 2022, 12(4), 772-788. https://doi.org/10.3390/agronomy12040772 (FI 3.7).
  21. CIOCARLAN, A. From (-)-sclareol to norlabdane heterocyclic hybrid compounds. In: Chemistry Journal of Moldova, 2022, 17(2), 30-45. http://dx.doi.org/10.19261/cjm.2022.958.
  22. GIRBU, V., ORGAN, A., GRINCO, M., COTELEA, T., UNGUR, N., BARBA, A., KULCITKI, V. Identification, Quantitative Determination and Isolation of Pomolic Acid from Lavender (Lavandula Angustifolia Mill.) Wastes. In: Sustainable Chemistry and Pharmacy, 2023, 33, 101140. https://doi.org/10.1016/j.scp.2023.101140 (FI 6.0).
  23. BLAJA S., LUNGU L., CIOCARLAN A., VORNICU N., ARICU A. Synthesis and evaluation of antimicrobial activity of tetranorlabdane compounds bearing 1,3,4-thiadiazole units. In: Chemistry Journal of Moldova, 2023, 18(1), 86-91.   https://doi.org/10.19261/cjm.2022.1026.
  24. LUNGU, L, BLAJA, S., CUCICOVA, C., CIOCARLAN, A., BARBA, A., KULCIȚKI, V. SHOVA, S., VORNICU, N., GEANA, E.-I., MANGALAGIU, I.I., ARICU, A. Synthesis and antimicrobial activity evaluation of homodrimane sesquiterpenoids with benzimidazole unit. In: Molecules, 2023, 28(3), 933, 1-14. https://doi.org/10.3390/molecules28030933 (FI 4.6).
  25. GRINCO, M., MORARESCU, O., LEMBO, F., UNGUR, N., TURCO, L., CORETTI, L., CARBONE, M., CELENTANO, C., CIAVATTA, M. L., MOLLO, E., KULCITKI, V., BUOMMINO, E. Synthesis and antimicrobial properties of guanidine-functionalized labdane type diterpenoids. In: European Journal of Medicinal Chemistry, 2024, 264, 115981. https://doi.org/10.1016/j.ejmech.2023.115981 (FI 6.7).


Patents

  1. KULCIŢKI, V., UNGUR, N., GRINCO, M., BUOMMINO E., LEMBO, F. Derivați guanidinici ai acizilor ent-gomerici cu proprietăți antimicrobiene și efect sinergistic în terapia combinată. Cerere de brevet de invenție (7114/2022.11.18)
  2. CIOCARLAN, A., POPESCU, V., LUPAȘCU, L., DRAGALIN, I., LUNGU, L., BLAJA, S., ARICU, A. Forma oxidată a uleiului volatil de coriandru cu proprietăți antifungice și antibacteriene. Cerere de brevet de invenție (7168/11.04.2023).
  3. CIOCARLAN, A., POPESCU, V., LUPAȘCU, L., DRAGALIN, I., LUNGU, L., BLAJA, S., ARICU, A., LUPAŞCU, G., GAVZER, S. Utilizarea formei oxidate a uleiului volatil de coriandru în calitate de inhibitor contra fungilor Fusarium avenaceum şi Fusarium equiseti. Cerere de brevet de invenție (7250/06.10.2023).
  4. KULCIŢKI, V., GIRBU, V., PRUTEANU, E., RENAUD, PH., DAELEMANS, D., MOLLO, E., DEFRANOUX, F., UNGUR, N. Metil ent-17-amino-kauran-19-oat cu activitate citotoxică selectivă. Brevet de invenție MD 4718 B1. In: BOPI, 10/2020, p. 47-48. http://agepi.gov.md/ro/bopi/10-2020.
  5. ARÎCU, A., CIOCARLAN, A., LUNGU, L., BLAJA, S., VORNICU, N.  5-(Homodrim-6,8-dien-11-il)-1,3,4-tiadiazol-2(3 H )-imină cu proprietăţi antifungice. Brevet de invenție 4765 B1, In: BOPI, 08/2021, p. 58-59. http://agepi.gov.md/sites/default/files/bopi/BOPI_08_2021.pdf
  1. ARÎCU, A., CIOCÂRLAN,  A.,  LUNGU, L., BLAJA, S., VORNICU, N. (Z/E )-2-(1-((1R,2R,8aS)-2-hidroxi-2,5,5,8a-tetrametildecahidronaftalen-1-il)propan-2-iliden)hidrazincarbotioamidă pentru utilizare în calitate de remediu antifungic. Brevet de invenție 4769. B1. In: BOPI, 10/2021, p. 44-45. http://agepi.gov.md/sites/default/files/bopi/BOPI_10_2021.pdf 
  2. KULCIŢKI, V., GIRBU, V., PRUTEANU, E., RENAUD, PH., DAELEMANS, D., UNGUR, N. Metil ent-15-hidroxi-16-azido-17-carboximetoximetilkauranoat cu activitate citotoxică selectivă. Brevet de invenție MD4785 (13) B1. In: BOPI, 2022, (1), p. 47-48. https://www.agepi.gov.md/sites/default/files/bopi/BOPI_01_2022.pdf#page=7.
  3. KULCIŢKI V., GÎRBU V., PRUTEANU E., RENAUD P., DAELEMAS D., UNGUR N. Noi spiro γ-lactame, derivate ale acidului ent-kaurenoic, cu activitate citotoxică selectivă. Brevet de invenție MD4786 (13) B1. In: BOPI, 2022, (1), p. 48-49. https://www.agepi.gov.md/sites/default/files/bopi/BOPI_01_2022.pdf#page=7.
  4. KULCIŢKI, V., GIRBU, V., PRUTEANU, E., RENAUD, PH., DAELEMANS, D., UNGUR, N. Ester metilic al acidului (16R)-spiro[pirolidin-2´, 16-ent-17-norkauran]-19-oic cu activitate citotoxică selectivă. Brevet de invenție MD4792 (13) B1. In: BOPI, 2022, (2), p. 57-58. https://www.agepi.gov.md/sites/default/files/bopi/BOPI_02_2022.pdf#page=7.
  5. KULCIŢKI, V., GIRBU, V., PRUTEANU, E., RENAUD, PH., DAELEMANS, D., UNGUR, N. Utilizarea metil ent-16-azido-17-carboxietoximetilkauranoatului în calitate de inhibitor selectiv al proliferării limfomului non-Hodgkin. Brevet de invenție MD4805 (13) B1. In: BOPI, 2022, (5), p. 55-56.
    https://www.agepi.gov.md/sites/default/files/bopi/BOPI_05_2022.pdf#page=7.
  6. LUNGU, L., CIOCARLAN, A., CUCICOVA, C., BLAJA, S., ARICU, A., VORNICU, N. 2-Amino-1-∆8,9-biciclohomofarnesenoil)-benzimidazol pentru utilizare în tratamentul afecțiunilor provocate de fungi și bacterii. Hotărâre AGEPI de acordare a BI nr. 10344 din 2023.10.25).

National projects

  1. Chemical study of secondary metabolites from local natural sources and valorization of their application potential basing on broadening molecular diversity with multiple functionality (code 010601)
    Period: 2024-2027
    Subprogram manager: dr. habilitate, assoc. prof. Veaceslav KULCITKI
     
  2.  ANCD/20.80009.8007.03. New products with preventive and therapeutic potential basing on natural products of vegetal origin and modern methods of organic synthesis
    Period: 2020-2023
    Project manager: dr. habilitate, assoc. prof. Veaceslav KULCITKI
     
  3. CSSDT/15.817.02.14A. Elaboration of methods for obtaining valuable terpenoids by valorization of renewable resources from Republic of Moldova
    Period: 2015-2019
    Project manager: dr. habilitate, assoc. prof. Nicon UNGUR
     
  4. CSȘDT/16.00353.50.04A. Design, directed synthesis and study of antibacterial and antitumor activity of chiral terpenic compounds and their coordinative combinations with transition metals
    Period: 2016-2017
    Project manager: Dr. habilitate, assoc. prof. Aculina ARICU
     

Bilateral projects

  1. AȘM-CNCI/18.80013.16.02.02/it. Synthesis of guanidine terpenoids with relevant biological activity and therapeutic potential
    Period: 2018-2019
    Project manager: Dr. habilitate, assoc. prof. Nicon UNGUR
     
  2. AȘM-STCU/18.80013.5007.01/6330STCU. Synthesis of biologically active norlabdanic compounds with heterocyclic structural units based on agricultural waste
    Period: 2018-2019
    Project manager: Dr. habilitate, assoc. prof. Aculina ARICU
     
  3. AȘM-ANCSI/16.80013.16.02.06/Ro. Directed synthesis and study of chiral complexes containing terpeno-heterocyclic ligands
    Period: 2016-2017
    Project manager: Dr. habilitate, assoc. prof. Aculina ARICU
     
  4. AȘM-STCU/15.820.18.03.07/5984STCU. Unconventional green processes for processing renewable raw materials
    Period: 2015-2017
    Project manager: Dr. habilitate, assoc. prof. Veaceslav KULCITKI
     
  5. AȘM-CNCI/15.820.16.02.02/it. Synthesis of guanidine terpenoids with relevant biological activity and therapeutic potential
    Period: 2015-2016
    Project manager: Dr. habilitate, assoc. prof. Nicon UNGUR
     

International project

  1. SCOPES/IZ73Z0-152346. Modification of natural compounds mediated by free radicals
    Period: 2015-2016
    Project manager: Dr. habilitate, assoc. prof.  Veaceslav KULCITKI

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