Gorincioi Elena

Title/degree Doctor, assoc. prof.
Position Leading scientific researcher
Laboratories Physical and Quantum Chemistry
Organic Synthesis
Office 145
Phone/fax (+373 22) 73 96 75
Email [email protected]
[email protected]
Professional links

Google scholar
Scopus Author ID
ORCID
Instrumentul Bibliometric Național
Research areas
  • Nuclear Magnetic Resonance in solutions and solids: applications in chemistry, biomedicine and agriculture
  • Biologically active natural and synthetic compounds
Relevant publications
Projects
  1. GORINCIOI E., LOZOVAN V., BOUROSH P., KRAVTSOV V. Ch., BULHAC I., IUNAC D., PRISACARI V., BARANETCHI I., ROTAR A., SKET P., PLAVEC J. NMR characteristics, crystal structure, antimicrobial properties and duplex DNA studies for the macrocyclic Co(III) complex obtained by template synthesis. Central European NMR Symposium & Bruker Users Meeting 2024, 18th-19th September, 2024, Rijeka, Croatia. Book of Abstracts, ISBN 978-953-8334-11-5, pag. 38. 
  2. GORINCIOI, E., STÎNGACI E., SKET P., PLAVEC J., MACAEV F. NMR studies of the duplex DNA-ligand interactions by using anticancer active primary amine ionic liquids. 10th International Conference on Materials Science and Condensed Matter Physics (MSCMP), 1-4 october 2024, Chisinau, Moldova. Book of abstracts, ISBN 978-9975-62-763-4, pag. 108. https://mscmp.usm.md/programme/
  3. GORINCIOI, E., STEFANET T., STÎNGACI E., VALICA V., MACAEV F. Full 1H, 13C and 15N NMR characterisation of dioxoindolinone endowed with antidepressant properties. 10th International Conference on Materials Science and Condensed Matter Physics (MSCMP), 1-4 october 2024, Chisinau, Moldova. Book of abstracts, ISBN 978-9975-62-763-4, pag. 109. https://mscmp.usm.md/programme/
  4. GORINCIOI, E., POGREBNOI, V., IUNAC D., BALAN G., ROTARU A., SUCMAN N., MACAEV F.  ANTIMICROBIAL, Antiproliferative and DNA-interacting properties of 6-(2,4-dichlorobenzoyl)-7-(2,4-dichlorophenyl)indolo[3,4-jk]phenanthridin-5(4H)-one. 10th International Conference on Materials Science and Condensed Matter Physics (MSCMP), 1-4 october 2024, Chisinau, Moldova. Book of abstracts, ISBN 978-9975-62-763-4, pag. 107. https://mscmp.usm.md/programme/
  5. GORINCIOI, E., BARBA, A., VICOL, C. Datele spectrale RMN - mărturii notabile în cercetarea interacțiunilor antioxidante: studii de caz privind unii metaboliți din struguri. CZU: 543.429.23:542.943`78:581.13:634.8 https://doi.org/10.59259/PRTEP2023_09. pag. 184-198, În monografia: PROCESE REDOX CU TRANSFER DE ELECTRONI ȘI PROTONI, Ed.: Acad., Prof. Gheorghe DUCA,   Chişinău: [Editura USM], 2023.  496 p.
  6. VERDEȘ Anastasia, GORINCIOI Elena, MACAEV Fliur. NMR characterization of (±)-monastrol, an inhibitor of the mitotic kinesin Eg5. The Central European NMR Symposium & Bruker Users Meeting 2023/solid-state NMR workshop, 13th-15th September, 2023, Prague, Czech Republic. Book of Abstracts, pag. 33.
  7. TALMACI, Natalia; DRAGANCEA, Diana; GORINCIOI, Elena; BOUROSH, Pavlina; KRAVTSOV, Victor. Crystal structure and NMR spectroscopic characterization of 1,5-bis(2-hydroxy-3-methoxybenzylidene)carbonohydrazide. Chemistry Journal of Moldova, 2023, vol. 18, Nr. 2, pag. 53-60, DOI: http://doi.org/10.19261/cjm.2023.1074
  8. Elena Gorincioi, Anastasia Verdes, Marina Zveaghintseva, Gheorghe Duca, Fliur Macaev. New non-natural bioactive heterocycles as promising binders to G-quadruplex DNA, International symposium on non-canonical nucleic acids ANNA-2023, 18-21 October, 2023, Maribor, Slovenia, Book of abstracts, pag. 50. https://slonmr.si/anna_2023/ANNA2023BookOfAbstracts.pdf
  9. GORINCIOI E., VICOL C., BARBA, A., DUCA Gh. Preliminary Results on 13C NMR Studies regarding the Radical Scavenging Activities Of Ascorbic Acid And Dihydroxyfumaric Acid Using 1,1-Diphenyl-2-picrylhydrazyl. Abstract book of the 7th International Conference ECOLOGICAL AND ENVIRONMENTAL CHEMISTRY-2022, March 3-4, 2022, Chisinau, Republic of Moldova, vol. 1, pag. 64. DOI: http://dx.doi.org/10.19261/eec.2022.v1
  10. VICOL C., GORINCIOI E., DUCA Gh. 13C NMR Investigations Of Radical Scavenging Activities Of Ascorbic Acid And Resveratrol Using 1,1-Diphenyl-2-picrylhydrazyl. 23rd International Conference “NEW CRYOGENIC AND ISOTOPE TECHNOLOGIES FOR ENERGY AND ENVIRONMENT"- EnergEn 2021, Băile Govora, Romania, October 26 – 29, 2021, Book of abstracts, pag. 312-316. https://www.icsi.ro/wp-content/uploads/2021/10/PROCEEDING-EnergEn-2021.pdf
  11. CUBA, Lidia; GORINCIOI, Elena; DRAGANCEA, Diana; SHOVA, Sergiu; BOUROSH, Pavlina. Noncovalent Interactions in the Architectures with Substituted Salicylaldehyde Semicarbazones.  In: Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya. 2021, nr. 7(47), pp. 488-501. DOI: https://doi.org/10.1134/S1070328421070034
  12. Vasile LOZOVAN, Victor Ch.KRAVTSOV, Elena GORINCIOI, Andrei ROTARU, Eduard B. COROPCEANU, Nikita SIMINEL, Marina S. FONARI. Chromism, positional, conformational and structural isomerism in a series of Zn(II) and Cd(II) coordination polymers based on methylated azineN,N'-donor linkers. Polyhedron, 180, 2020, 114411. DOI: https://doi.org/10.1016/j.poly.2020.114411
  13. Gorincioi, E.,Coropceanu, E. NMR STUDIES OF SOME Zn AND Cd COORDINATION COMPOUNDS BEARING 1,2-CICLOHEXANEDIONEDIOXIME. Chemistry Journal of Moldova, 2018, 13(2), p. 38-47. DOI: http://dx.doi.org/10.19261/cjm.2018.368
  14. Cuba, L., Bourosh, P., Kravtsov, V., Gorincioi, E., Dragancea, D. OXIDO- AND DIOXIDOVANADIUM(V) COMPLEXES WITH O-VANILLIN SEMICARBAZONE: SYNTHESIS AND CRYSTAL STRUCTURE. Chemistry Journal of Moldova, 2018, 13(1), p. 36-45. DOI:http://dx.doi.org/10.19261/cjm.2018.477
  15. Lidia Lungu, Dmitri Bilan, Aculina Arîcu, Alexandru Ciocârlan, ElenaGorincioi, Fliur Macaev. SYNTHESIS AND NMR CHARACTERIZATION OF SOME NEW COMPOUNDS WITH COMBINED SKELETON CONTAINING HETEROCYCLE PHARMACOPHORES. 19th Central and Eastern European NMR symposium and Bruker Users’ meeting, 5-8th of September, 2017, Timișoara, România. Book of Abstracts, pag. 22.
  16. Grinco M., Gîrbu V., Gorincioi E., Barba A., Kulciţki V., Ungur N.THE FIRST BIOMIMETIC SYNTHESIS OF A DITERPENOID WITH THE ENT-VERRUCOSIN A/B SKELETON. Tetrahedron Letters, 2016, 57(19), pp. 2084– 2086. DOI: https://doi.org/10.1016/j.tetlet.2016.03.106
  17. A. N. ARICU, K. I. KUCHKOVA, A. N. BARBA, I. P. DRAGALIN, S. G. SHOVA, N. VORNICU, E. K. GORINCHOI, E. S. SEKARA, L. V. LUNGU, M. NICULAUA, N. D. UNGUR, AND P. F. VLAD. Synthesis from norambreinolide, structure, and antimicrobial activity of dihomodrimane sesquiterpenoids with azine, hydrazide, and dihydrazide fragments. Chemistry of Natural Compounds, 2016, 52(6), pp.1029-1036. DOI 10.1007/s10600-016-1854-6.
  18. Natalia Mashcenko, Angela Gurev, Galina Lupascu, Elena Gorincioi. IRIDOID GLYCOSIDES FROM LINARIA GENISTIFOLIA (L.) MILL. IN BIOLOGICAL CONTROL OF SOIL-BORNE FUNGAL PATHOGENS OF WHEAT AND SOME STRUCTURE CONSIDERATIONS. Chem. J. Mold. 2015, 10(1), 57-63. DOI: dx.doi.org/10.19261/cjm.2015.10(1).08
  19. Elena Gorincioi, Alic Barba, Ion Geru, Alexandru Ciocarlan, Carolina Edu, Tatiana Sirbu, Kaleria Kuchkova, Aculina Aricu, Ionel Mangalagiu, Alina Nicolescu and Calin Deleanu. Extensive 1H and 13C NMR analyses of some unusual tetranorlabdane compounds. 14th Central and Eastern European NMR symposium and Bruker Users’ meeting, 16th-19th September, 2012, Golden Sands, Bulgaria. Programme and Book of Abstracts, pag. 61.
  20. Alexandra Marchenko, Pavel Kintia, Bozena Wyrzykiewicz and Elena Gorincioi. “Steroidal glycosides from Veronica chamaedrys L. Part I. The structures of chamaedrosides C, C1, C2, E, E1 and E2”. Natural Product Communications, 2012, Vol. 7, Nr. 5, pp. 565 – 568. https://doi.org/10.1177/1934578X1200700504
  21. Mehdi Rajabi, Elena Gorincioi, Enzo Santaniello. Anti-proliferative activity of Kinetin Riboside on HCT-15 colon cancer cell lines. Nucleosides, Nucleotides & Nucleic Acids, 2012, Vol. 31, pp. 474 – 481. DOI: http://dx.doi.org/10.1080/15257770.2012.681825
  22. Victor Ch. Kravtsov, Elena C. Gorincioi, Alic N. Barba, Aculina N. Aricu, Janusz Lipkowski, Pavel F. Vlad. X-ray Structure Study of an Unusual 13,14,15,16- Tetranorlabdane Derivative Obtained in the Synthesis of (7a)-7,8-Dihydroxy-14,15-dinorlabdane -11,13-dione. Helvetica Chimica Acta, 2012, Vol. 95, 825-830
  23. Alberto Milanese; Elena  Gorincioi; Mehdi  Rajabi; Giulio  Vistoli; Enzo  Santaniello. New synthesis of 6[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid  and evaluation of the influence of adamantyl group on the DNA binding of a naphthoic retinoid. Bioorganic Chemistry, 2011, Vol. 39, 151-158. DOI:10.1016/j.bioorg.2011.07.003
  24. Andrei Rija, Ion Bulhac, Eduard Coropceanu, Elena Gorincioi, Elena Calmîc, Alic Barbă, Olga Bologa. Synthesis and spectroscopic study of some coordinative compounds of Co(III), Ni(II) and Cu(II) with dianilin- and disulfanilamideglioxime.  Chemistry Journal of Moldova, 2011, 6(2), 73-78. DOI: dx.doi.org/10.19261/cjm.2011.06(2).16
  25. M. Rajabi, J. Mehrzad, E. Gorincioi, E. Santaniello. Antiproliferative Activity of N6-Isopentenyladenosine (iPA) on HCT-15 Colon Carcinoma Cell Line. Nucleic Acid Therapeutics, 21, 2011, 355-358. DOI: 10.1089/nat.2011.0314
  26. P. Vlad, E. Gorincioi, A. Aricu, A. Barba, A. Manzocchi, E. Santaniello. Asymmetric dihydroxylation of drim-7-en-11-ol: synthesis of diastereomerically pure driman-7a,8a,11-triol and its elaboration into novel chlorinated norlabdanic compounds. Tetrahedron: Asymmetry, 2010, 21, 2108-2116. DOI: doi:10.1016/j.tetasy.2010.06.029
  27. M. Rajabi, P. Signorelli, E. Gorincioi, R. Ghidoni, E. Santaniello. Antiproliferative Activity of N6-Isopentenyladenosine on MCF-7 Breast Cancer Cells: Cell Cycle Analysis and DNA-Binding Study. DNA and Cell Biology, 2010, 29, Nr. 11, 687-691. DOI: 10.1089/dna.2010.1073
  28. M. Rajabi, E.Gorincioi, E. Santaniello. N6-Isopentenyladenosine, an isoprenoid cytokinin endowed with biological activity: cytotoxicity against MDA-MB-231 breast cancer cell line and interaction with bovine serum albumin. Iranian Journal of Organic Chemistry, 2010, V. 2, No. 1, 278-284
  29. P.F.Vlad, M.N.Coltsa, A.N.Aryku, A.G.Ciocarlan, E.C.Gorincioi, C.G.Edu, C.Deleanu. Photooxidative dehydrogenation of  D8-drimen- and  D8-11-homodrimen-7-ones into a,a¢- dienones. Russian Chemical Bulletin, Int. Ed., 2006, V. 55, № 4, pp.703-706. https://doi.org/10.1007/s11172-006-0316-x
  30. A. A. Panasenko, E. C. Gorincioi, A. N. Arâcu, E. A. Barcari, K. Deleanu, P. F. Vlad. 1H and 13C NMR spectra of some drimanic sesquiterpenoids. Russian Chemical Bulletin, Int. Ed., 2004, Vol. 53, № 12, pp. 2700- 2705. https://doi.org/10.1007/s11172-005-0178-7
  31. V.Kh. Kravtsov, Yu.A. Simonov, E.K. Gorincioi, M.N. Coltsa, P.F. Vlad. Crystal and Molecular Structures of 11,12-Epoxydrim-8(9)-en-11b-ol-7-one.  Crystallography Reports, 2000, Vol.45, No.5, pp. 789-791. https://doi.org/10.1134/1.1312922
  32. Vlad P.F., Gorincioi E.C., Coltsa M.N., Deleanu C. Synthesis of isodrimenin from drim-8-en-7-one. Russian Chemical Bulletin, Int. Ed., 2000, Vol.49, № 3, pp. 546-548. https://doi.org/10.1007/BF02494791
  33. Vlad P.F., Popa D.P., Gorincioi E.C., Coltsa M.N., Mironov G.N. Synthesis of 11-hydroxydrim-8(9)-en-7-one and 11,12-dihydroxydrim-8(9)-en-7-one from drim-8-en-7-one.  Russian Chemical Bulletin, Int. Ed., 2000, Vol. 49, № 1, pp. 98-101. https://doi.org/10.1007/BF02499072
  34. V.Kh. Kravtsov, E.K. Gorincioi, G. N. Mironov, M.N. Coltsa, Yu.A. Simonov, P.F. Vlad. Crystal and Molecular Structure of 11,12-Dihydroxydrim-8(9)-en-7-one.  Crystallography Reports, 2000, Vol.45, № 2, pp. 258-260. https://doi.org/10.1134/1.171176
  35. P.F. Vlad, E.C. Gorincioi, A.N. Arâcu, M.N. Coltsa. A short, efficient synthesis of (-)-(3aS, 7aS) – trans-tetrahydroactinidiolide. Natural Product Letters, 1999, Vol.13, № 1, pp.1-4.

Național projects

  1. ANCD/20.80009.5007.27. Physico-chemical mechanisms of redox processes with electron transfer involved in vital, technological and environmental systems
    Period: 2020-2023
    Project manager: Acad., dr. habilitate, prof. Gheorghe DUCA
  2. ANCD/20.80009.5007.17. Hybrid materials functionalized with carboxyl groups based on plant metabolites with activity against human and agricultural pathogens
    Period: 2020-2023
    Project manager: Dr. habilitate, prof. Fliur MACAEV
  3. CSSDT/15.817.02.02F. Study of mechanisms of chemical reactions, electronic structure and physico-chemical properties of transitiom-metal coordination compounds and nanoparticles A2B6
    Period: 2015-2019
    Project manager: Dr., assoc. prof. Natalia GORINCIOI


International project

  1. Research project Nr. 20232127 won in the framework of the CERIC-ERIC supported projects, Title: Solution NMR studies of the duplex and G-quadruplex DNA-ligand interactions by using some bioactive compounds. Realization period: 2023. Status of the project: successfully finalized, data under preparation for dissemination. Project manager: Dr. Elena GORINCIOI.