Aromatic methyl ketones in the synthesis of biologically active heterocyclic compounds

Every year, the vineyards, gardens and orchards of the Republic of Moldova are affected by Noble Rot (Botrytis cinerea), Downy mildew (Plasmopara viticola Berl. Et Toni), Oidium tuckeri (Uncinula necator), Fire blight (E. Carotovora) and other diseases, which affects a wide range of agricultural plant species. These are some of the most devastating and serious diseases, which attack the bunches and berries of grapes, the stems and leaves of potatoes, tomatoes and peppers, fruits of apples and pears, diseases that cause the vineyards and orchards damage in our country. Modern treatments have a weak effect. Farmers invest a lot in treatments, which only manage to stop the evolution of the fungus, but do not lead to the complete eradication of the disease. The high resistance of most phytopathogenic bacteria, and as a result, the total destruction of the crop is one of the most pressing problems facing agricultural producers not only in Moldova but also in other states, where the agro-industrial complex is of particular importance in the country's economy. The discovery of new effective chemical agents with a disease-healing profile, superior to existing substances and minimal toxicity, as well as their correct use in treatment, is one of the main tasks of scientists around the world. Taking into account these aspects, the present project proposes the development of hybrid molecules in an enantiomerically pure state with antimycobacterial properties.
The synthesis of the targeted compounds will focus on obtaining molecules with diterpene fragment as a source of chirality, combined with the heterocyclic fragment. The development of new hybrid materials presents a fascinating field of research, which encourages the search for new materials with high biological efficiency, thanks to the concomitant presence of heterocyclic and natural fragments. In particular, it is of interest to obtain hybrid molecules for the selective delivery of the remedy to the site of action, to improve bioavailability, to reduce the toxicity of preparations and last but not least, to minimize the resistance of phytopathogenic bacteria. All new compounds will be isolated, purified and characterized by various physico-chemical methods. The investigation of biological properties will be done using different species of pathogenic bacteria. After obtaining the results of the evaluation of the biological activity, the recommendations for their use in practice will be stipulated.