Laboratory of Chemistry of Natural and Biologically Active Compounds

poza

 

Head of the laboratory 
dr. habilitate, assoc. prof. Veaceslav KULCIȚKI

 

Office:  309
Phone: (+373 22) 73 99 92
Email: kulcitki @ yahoo.com
veaceslav.kulcitki @ ichem.md




Short history

The Laboratory Chemistry of Natural Compounds was founded in 1959 and headed then by acad. Gheorghe Lazurievski. The research activity developed fruitfully and the laboratory expanded significantly by several independent research groups, covering different areas of natural product chemistry. Consequently, it was divided in 1976 into three separate laboratories: Chemistry of Steroidal Compounds (headed by dr. Petru Ceban), Chemistry of Isoprenoids (headed by dr. Dumitru Popa) and Chemistry of Ethereal-Oleaginous Plants (headed by acad. Pavel Vlad).

Later on, after several structural changes, two of these laboratories merged in 1991 into the Laboratory of Terpenoid Chemistry (headed by acad. Pavel Vlad). Then, the laboratory was renamed into the Laboratory of Chemistry of Natural and Biologically Active Compounds (2016).

Research areas
  • Targeted synthesis of polifunctionalized bioactive terpenic compounds;
  • Elaboration of methods for renewable resources valorization;
  • Elaboration   of    new   green   methods   for   the modification of natural products.
Staff
Recent publications
Research projects
Noutăți
Veaceslav KULCITKI
dr. habilitate, assoc.prof.
Head of the laboratory
office 309
Phone: (+373 22) 73 97 75
email: kulcitki @ yahoo.com, veaceslav.kulcitki @ ichem.md
Nicon UNGUR
dr. habilitate, assoc.prof.
Principal scientific researcher
office  301
phone: (+373 22) 73 97 75
email: nicon.ungur @ gmail.com, nicon.ungur @ ichem.md
Aculina ARICU
dr. habilitate, assoc. prof.
Principal scientific researcher
birou  308
tel.: (+373 22) 72 71 23
email: aculina.aricu @ gmail.comaculina.aricu @ ichem.md
Ion DRAGALIN
dr.  assoc. prof.
Leading scientific researcher
office  306
phone: (+373 22) 73 97 69
email: iondragalin @ yahoo.com, ion.dragalin @ ichem.md
Alexandru CIOCARLAN
dr.  conf. cerc.
Senior scientific researcher
office  304
phone: (+373 22) 73 97 69
email: algciocarlan @ yahoo.com, alexandru.ciocarlan @ ichem.md
Marina GRINCO
dr.  conf. cerc.
Senior scientific researcher
office  310
phone: (+373 22) 73 97 69
email: grinkom @ yahoo.com, marina.grinco @ ichem.md
Caleria CUCICOVA
dr.  conf. cerc.
Senior scientific researcher
office  318
phone: (+373 22) 73 97 69
email: cucicovac @ yahoo.com
Olga MORARESCU
dr. 
Scientific researcher
office  310
phone: (+373 22) 73 97 69
email: olgamorarescu7 @ gmail.com, olga.morarescu @ ichem.md
Lidia LUNGU
dr. 
Scientific researcher
office  307
phone: (+373 22) 73 97 69
email: lidialungu @ ymail.com, lidia.lungu @ ichem.md
Elena SECARA-CUȘNIR
dr. 
Scientific researcher
office  318
phone: (+373 22) 73 97 69
email: esecara8 @ gmail.com, elena.secara-kusnir @ ichem.md
Vladilena GIRBU
dr. 
Scientific researcher
office  304a
phone.: (+373 22) 73 97 69
email: vgirbu1 @ gmail.com, vladilena.girbu @ ichem.md
Alic BARBA
dr.
Leading scientific researcher
office 145
phone: (+373 22) 73 96 49
email: [email protected];  [email protected]
Svetlana BLAJA
dr.                                                                Stagiar scientific researcher
office  307
phone: (+373 22) 73 97 69
email: svetlana-blaja @ mail.ru, svetlana.blaja @ ichem.md

Manuals, chapters in monographs

  1. ARÎCU, A., KULCIȚKI, V., UNGUR, N. Sclareolul - Materie Primă Sustenabilă Pentru Sinteza Compușilor Terpenici cu Valoare Adăugată Înaltă. În: Chimie Ecologică: Istorie și Realizări. Academicianul Gheorghe Duca, 70 Ani de la Naștere. Chișinău, 2022, pp. 86-114. ISBN 978-9975-159-05-0.
  2. ARÎCU, A., LUNGU, L., BLAJA, S., CUCICOVA, C., CIOCÂRLAN, A. Sinteza și Studiul Activității Antimicrobiene a Compușilor Norlabdanici cu Unități Structurale Heterociclice. In: Acad. A. Gulea - Conferinţa Ştiinţifică Naţională cu participare Internaţională: „Materiale Avansate în Biofarmaceutică şi Tehnică”, Culegere de articole, Chişnău, 2021, p. 10-34.
  3. UNGUR, N.; MORARESCU, O. Sinteza Dirijată a Unor Diterpenoide Tetraciclice Bioactive din Acidul ent-Kaur-16-en-19-oic”. In: Acad. A. Gulea - Conferinţa Ştiinţifică Naţională cu participare Internaţională: „Materiale Avansate în Biofarmaceutică şi Tehnică”, Culegere de articole, Chişnău, 2021, 294-313.
  4. KULCIȚKI, V. Strategia Sintezei Organice. Principii Generale și Noțiuni Fundamentale. Suport de curs. USDC, Chișinău, 2020. ISBN 978-9975-89-164-6. 94 p.
  5. KULCIȚKI, V. Istoria și Evoluția Cercetării în Chimie. Suport de curs. USDC, Chișinău, 2019. ISBN 978-9975-108-98-0. 114 p.
  6. ARICU, A.; UNGUR, N.; DUCA, Gh. Design, Targeted Synthesis and Study of Biological Activity of Some Polifunctional Chiral Terpenic Compounds. In: Compounds and materials for drug development and biomedical applications, Resp. ed. Gh G. Duca, F. Z. Macaev, Editura Academiei Române; Editura Istros a Muzeului Brăilei „Carol I”, 2018, pp. 101-126. ISBN 978-973-27-2944-1.
  7. UNGUR, N.; ARÎCU, A.; GRINCO, M. Occurrence, Biological Activity and Synthesis of Diterpenoid Amides. In: Diterpenoids. Types, Functions and Research. Brandon Jones Ed., Nova Science Publishers, Inc., New York, 2017, pp. 1-38. ISBN 9781536106718.

Articles

  1. CIOCARLAN, A., DRAGALIN, I., ARICU, A., LUPASCU, L., CIOCARLAN, N., VERGEL, K., DULIU, O.G., HRISTOZOVA, G., ZINICOVSCAIA, I. Chemical profile, elemental composition, and antimicrobial activity of plants of the Teucrium (Lamiaceae) genus growing in Moldova. In: Agronomy, 2022, 12(4), 772-788. (FI 2.24). DOI: https://doi.org/10.3390/agronomy12040772
  2. CIOCARLAN, A., LUPASCU, L., ARICU, A., DRAGALIN, I., POPESCU, V., GEANA, E.I., IONETE, R.E., VORNICU, N., DULIU, O.G., HRISTOZOVA, G., ZINICOVSCAIA, I. Chemical composition and assessment of antimicrobial activity of lavender essential oil and some by-products. In: Plants, 2021, 10(9), 1829-1843. (FI 3.935). DOI: https://doi.org/10,3390/plants1091829.
  3. URECHE, D., BULHAC, I., CIOCARLAN, A., ROSHCA, D., LUPASCU, L., BOUROSH, P. Novel vic-Dioximes: synthesis, structure characterization and antimicrobial activity evaluation. In: Turkish Journal of Chemistry, 2021, 45(6), 1873-1881. (FI 1.239). DOI: 10.3906/kim-2104-24
  4. CIOCARLAN, A., HRISTOZOVA, G., ARICU, A., DRAGALIN, I., ZINICOVSCAIA, I., YUSHIN, N., GROZDOV D., POPESCU, V. Determination of the elemental composition of aromatic plants cultivated industrially in the Republic of Moldova using neutron activation analysis. In: Agronomy, 2021, 11(5), 1011-1030. (FI 2.603) DOI: 10.3390/agronomy11051011
  5. GEANĂ, E.-I., CIUCURE, C.T., IONETE, R.E., CIOCARLAN, A., ARICU, A., FICAI, A., ANDRONESCU, E. Profiling of phenolic compounds and triterpene acids in different apple (Malus domestica Borkh.) cultivars. In: Foods, 2021, 10(2), 267-282. (FI 4.350). DOI: https://doi.org/10.3390/foods10020267
  6. BLAJA, S.P., LUNGU, L.V., KUCHKOVA, K.I., CIOCARLAN, A.G., BARBA, A.N., VORNICU, N., ARICU, A.N. Norlabdane compounds containing thiosemicarbazone or 1,3-thiazole fragments: Synthesis and antimicrobial activity. In: Chemistry of Natural Compounds, 2021, 57(1), 101-110. (FI 0.809).  DOI: https://doi.org/10.1007/s10600-021-03292-3
  7. CIOCARLAN, A., LUPASCU, L., ARICU, A., DRAGALIN, I., CIOCARLAN, N., ZINICOVSCAIA, I., SLANINA, V., YUSHIN, N. Chemical composition of the essential oil and antimicrobial properties of crude extract from Tanacetum corymbosum (L.). In: Chemistry Journal of Moldova, 2021, 16(2), 83-90.  DOI: 10.19261/cjm.2021.877
  8. CIOCARLAN, A. (+)-Larixol and larixyl acetate: syntheses, phytochemical studies and biological activity assessments. In: Chemistry Journal of Moldova. 2021, 16, (1), pp. 30-45.  DOI: https://doi.org/10.19261/cjm.2021.836
  9. MORARESCU, O.; GRINCO, M.; KULCIŢKI, V.; BARBA, A.; GARBUZ, O.; GULEA, A. and UNGUR, N. Synthesis of Highly Functionalized Biologically Active Tetracyclic Diterpenoids from ent-Kaur-16-en-19-oic Acid under Modified Prévost-Woodward Reaction Conditions. In: Russ. J. Org. Chem., 2021,  57, 1931–1939. (FI 0.723) DOI: 10.1134/S1070428021120058.
  10. MORARESCU, O., GRINCO, M., KULCIŢKI, V., SHOVA, S., UNGUR, N. An Alternative Approach towards C-12 Functionalized Scalaranic Sesterterpenoids. Synthesis of 17-Oxo-20-norscalaran-12α,19-O-lactone. In: Marine Drugs, 2021, 19(11), 636. (FI 5.118) DOI: 10.3390/md19110636.
  11. PRUTEANU, E., GÎRBU, V., UNGUR, N., PERSOONS, L., DAELEMANS, D., RENAUD, P. and KULCIȚKI, V. Preparation of Antiproliferative Terpene-Alkaloid Hybrids by Free Radical-Mediated Modification of ent-Kauranic Derivatives. In: Molecules, 2021, 26(15), pp. 4549-4568. (FI 4.412) DOI: 10.3390/molecules26154549.
  12. ORGAN, A.; GÎRBU, V.; COJOCARU-TOMA, M.; KULCIŢKI, V.; COTELEA T.; UNGUR, N. Therapeutic potential and preventive effects of major triterpenic secondary metabolites from Lavandula angustifolia. In: Revista Farmaceutică a Moldovei, 2021, 45(1), 79-81.
  13. MORARESCU, O., TRAISTARI, M., BARBA, A., DUCA, G., UNGUR, N. and KULCIȚKI, V. One-step selective synthesis of 13-epi-manoyl oxide. In: Chem.J.Mold., 2021, 16 (1), pp. 99-104.  DOI: http://dx.doi.org/10.19261/cjm.2021.820.
  14. PRUTEANU, E.; TAPPIN, N.D.; GÎRBU, V.; MORARESCU, O.; DÉNÈS, F.; KULCIŢKI, V. and RENAUD, P. Forskolin Editing via Radical Iodo-and Hydroalkylation. In: Synthesis, 2021, 53(07), pp. 1247-1261. (FI 3.157)  DOI: 10.1055/s-0040-1706003.
  15. MORARESCU, O.; GRINCO, M.; KULCIŢKI, V.; BARBA, A.; GARBUZ, O.; GUDUMAC, V.; GULEA, A. and UNGUR, N. A Straightforward Synthesis of Natural Oxygenated ent-Kaurenoic Acid Derivatives. In: Synthetic Communications, 2021, 51(1), pp. 123-133. (FI 2.007). DOI: 10.1080/00397911.2020.1821225.
  16. D.Ia.Bilan, N.S.Sucman, O.M.Radul, I.P,Dragalin, A.N.Barba, F.Z.Macaev,       Sintez proizvodnîh (-)-ConvolutamidinaA i analogov. In: Himia prirodnîh soedinenii, 2021,  Nr. 3, pp.440-443. (FI 0.809).
  17. ARICU, A. N., KUCHKOVA, K. I., SECARA-CUSHNIR, E. S., BARBA, A. N., UNGUR, N. D., VORNICU, N. Synthesis and Antimicrobial Activity of New Drimane and Homodrimane Sesquiterpenoids with Oxadiazole and Thiadiazole Fragments. In: Chemistry of Natural Compounds. 2020, nr. 4(56), pp. 656-662. (FI 0.809).   DOI: https://doi.org/10.1007/s10600-020-03115-x
  18. LUNGU, L., CIOCARLAN, A., SMIGON, C., OZER, I., SHOVA, S., GUTU, I., VORNICU, N., MANGALAGIU, I., D'AMBROSIO, M., ARICU, A.. Synthesis and evaluation of biological activity of homodrimane sesquiterpenoids bearing 1,3,4-oxadiazole or 1,3,4-thiadiazole units. In: Chemistry of Heterocyclic Compounds, 2020, 56(5), 578-585. (FI 1.492). DOI: 10.1007/s10593-019-02526-1.
  19. ZINICOVSCAIA, I., GUNDORINA, S., VERGEL, K., GROZDOV, D., CIOCARLAN, A., ARICU, A., DRAGALIN, I., CIOCARLAN, N. Elemental analysis of Lamiaceae medicinal and aromatic plants growing in the Republic of Moldova using neutron activation analysis. In: Phytochemistry Letters, 2020, 35, 119-127. (FI 1.338). DOI: 10.1016/j.phytol.2019.10.009
  20. CIOCARLAN, A., LUNGU, L., BLAJA, S., DRAGALIN, I., ARICU, A. The use of some non-conventional methods in chemistry of bicyclohomofarnesenic methyl esters. In: Chemistry Journal of Moldova, 2020, 15(2), 69-77. DOI: https://doi.org/10.19261/cjm.2020.791.
  21. ELENA PELEAH, VICTOR MELNIC, ION DRAGALIN. Polichimismul intraspecific Mentha spicata. In: Studia Universitatis Moldaviae, 2020, 6 (136), pp. 60-63.
  22. INGA ZINICOVSCAIA ALEXANDRU CIOCARLAN, LUCIAN LUPASCU, ACULINA ARICU, ION DRAGALIN, NINA CIOCARLAN & NIKITA YUSHIN. Chemical analysis of Tanacetum corymbosum (L.) Sch. Bip. uising neutron activation. In: Journal of Radioanalitical and Nuclear Chemistry, 2019, 321 (2), pp. 349-354. (FI 0.983).  DOI: 10.1007/s10967-019-06590-x
  23. LUNGU, LIDIA; CIOCARLAN, ALEXANDRU; BARBĂ, ALIC; SHOVA, SERGIU; POGREBNOI, SERGHEI; MANGALAGIU, IONEL; MOLDOVEANU, COSTEL; VORNICU, NICOLETA; AMBROSIO, MICHELE; BABAK, MARIA V.; ARION, VLADIMIR; ARICU, ACULINA. Synthesis and Evaluation of Biological Activity of Homodrimane Sesquiterpenoids Bearing Hydrazinecarbothioamide or 1,2,4-Triazole Unit. In: Chemistry of Heterocyclic Compounds. 2019, 55(8), pp. 716-724. ISSN 0009-3122.  DOI: 10.1007/s10593-019-02526-1.
  24. ARICU, ACULINA; NASTAS, RAISA; COCU, MARIA. The institute of chemistry at 60 years anniversary. brief history, achievements and perspectives. In: Chemistry Journal of Moldova. 2019, nr. 1(14), pp. 8-31. ISSN 1857-1727. DOI: 10.19261/cjm.2019.349.
  25. SÎRBU, T.; GIRBU, V.; HARGHEL, P.; RUSU, V.; UNGUR, N. and KULCIŢKI, V. Selectivity Control in Terpene Rearrangements: A Biomimetic Synthesis of the Halimanic Bicyclic Core. In: Synthesis, 2019, 51(09), pp. 1995-2000. (FI 3.157). DOI: 10.1055/s-0037-1610686.
  26. DUCA, Gh.; ARICU, A.; KUCHKOVA, K.; SECARA, E.; BARBA, A.; DRAGALIN, I.; UNGUR, N.; SPENGLER, G. Synthesis and Anticancer Activity of New Guanidine - Containing Diterpenoids. In: Nat. Prod. Res., 2019, 33 (21), 3052-3056. (FI 1.928). DOI: 10.1080/14786419.2018.1516658
  27. DUCA GH., ARICU A., LUNGU L., TENU N., CIOCARLAN A., GUTU Y., DRAGALIN I., BARBA A. Synthesis of new homodrimane sesquiterpenoids containing diazine, 1,2,4-triazole and carbazole rings. In: Chem. J. Mold., 2018, vol. 13, nr.1, p. 69-73. DOI:http://dx.doi.org/10.19261/cjm.2017.458.
  28. CIOCARLAN A., DRAGALIN I., ARICU A., CIOCARLAN N., STAVARACHE C., M. DELEANU. Chromatographic analysis of Silybum Marianum (L.) Gaertn. Fatty oil. In: Chem. J. of Moldova, 2018, vol. 13, nr. 1, p. 63-68.  DOI: http://dx.doi.org/10.19261/cjm.2018.484 .
  29. ALEXANDRU CIOCARLAN, ION DRAGALIN, ACULINA ARICU, LUCIAN LUPASCU, NINA CIOCARLAN, VIOLETA POPESCU. Chemical composition and antimicrobial activity of the Levisticum officinale W.D.J. Koch essential oil. In: Chem. J. Mold, 2018, 13(2), 63-68.  DOI: http://dx.doi.org/10.19261/cjm.2018.514
  30. MICHELE D'AMBROSIO, ALEXANDRU CIOCARLAN, ACULINA ARICU. Minor acetylated metabolites from Euphrasia rostkoviana. Natural and synthetic acetylated derivatives of rutin. In: Nat. Prod. Res., 2018, 34(2), 290. (FI 1.928). DOI: https://doi.org/10.1080/14786419.2018.1530227.
  31. ARICU, A. N.; KUCHKOVA, K. I.; SECARA, E. S.; BARBA, A. N.; DRAGALIN, I. P.; UNGUR, N. D.; MELNIK, E.; KRAVTSOV, V. Kh. Synthesis and Structure of Drimane Sesquiterpenoids Containing Pyrimidine, Pyrazine, 1,2,4-triazole, and Carbazole Rings. In: Chem.Nat. Comp., 2018, 54 (3), 455-460. (FI 0.509).  DOI: https://doi.org/10.1007/s10600-018-2378-z
  32. CARBONE, M.; CIAVATTA, M. L.; MATHIEU, V.; INGELS, A.; KISS, R.; PASCALE, P.; MOLLO, E.; UNGUR, N.; GUO, Y.-W.; GAVAGNIN, M. Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues. In: J. Nat. Prod., 2017, 80 (5), 1339-1346. (FI 3.885). DOI: https://doi.org/10.1021/acs.jnatprod.6b00941
  33. CIOCARLAN A., ARICU A., LUNGU L., EDU C., BARBA A., SHOVA S., MANGALAGIU I. I., D’AMBROSIO M., NICOLESCU A., DELEANU C., VORNICU N. Synthesis of novel tetranorlabdane derivatives with unprecedented carbon skeleton. In: Synlett, 2017, vol. 28, nr, 05, p. 565–571. (FI 2.32). DOI: 10.1055/s-0036-1588651. ISSN 1437-2096

Patents

  1. KULCIŢKI, V., GIRBU, V., PRUTEANU, E., RENAUD, PH., DAELEMANS, D., UNGUR, N. New Spiro-g-Lactams, ent-Kaurenoic Acid Derivatives, with Selective Cytotoxic Activity. Patent Nr  4786 (13) B1, BOPI, 2022, (1), pp. 49.
  2. KULCIŢKI, V., GIRBU, V., PRUTEANU, E., RENAUD, PH., DAELEMANS, D., UNGUR, N. Methyl ent-15-hydroxy-16-azido-17-carboxymethoxymethylkauranoate with Selective Cytotoxic Activity. Patent Nr  4785 (13) B1, BOPI, 2022, (1), pp. 47-48.
  3. KULCIŢKI, V., GIRBU, V., PRUTEANU, E., RENAUD, PH., DAELEMANS, D., UNGUR, N. (16R)-Spiro[pyrrolidine-2´,16-ent-17-norkauran]-19-oic Acid Methyl Ester with Selective Cytotoxic Activity. Patent Nr  4792 (13) B1, BOPI, 2022, (2), pp. 57-58.
  4. ARÎCU, A., CIOCÂRLAN, A., LUNGU, L., BLAJA, S., VORNICU, N. (Z/E)-2-(1-((1R,2R,8aS)-2-hidroxi-2,5,5,8a-tetrametildecahidronaftalen-1-il)propan-2-iliden)hidra- zincarbotioamidă pentru utilizare în calitate de remediu antifungic. Patent MD 4769.
  5. ARÎCU, A., CIOCÂRLAN, A., LUNGU, L., BLAJA, S., VORNICU, N. 5-(Homodrim-6,8-dien-11-il)-1,3,4-tiadiazol-2(3H)-imină cu proprietăţi antifungice. Patent MD 4765.
  6. KULCIŢKI, V.; GÎRBU, V.; PRUTEANU, E.; RENAUD, P.; DAELEMAS, D.; MOLLO, E.; DEFRANOUX, F.; UNGUR, N. Methyl ent-17-amino-kauran-19-oate with Selective Cytotoxic Activity. Patent Nr  4718 (13) B1, BOPI, 2020, (10), pp. 47-48.
  7. ARÎCU, A.; KUCHKOVA, K.; DUCA, GH.; SECARA, E.; BARBA, A.; DRAGALIN, I.; UNGUR, N. Compusul 1-(4-((4aS,8aS)-2,5,5,8a-tetrametil-3,4,4a,5,6,7,8,8a-octahidronaftalen1-il)butan-2-il)guanidină cu activitate antiproliferativă şi citotoxică. Patent Nr. 4630, MD, BOPI, 2019, (5), p.41.
  8. ARÎCU, A.; KUCHKOVA, K.; DUCA, GH.; SECARA, E.; BARBA, A.; DRAGALIN, I.; UNGUR, N. Compusul N-carbamimidoil-2-((8aS)-2,5,5, 8a-tetrametil-3,4,4a,5,6,7,8,8aoctahidronaftalen-1-il)acetamidă cu activitate antiproliferativă şi citotoxică. Patent Nr. 4631, MD, BOPI, 2019, (5), p.41-42.
  9. ARÎCU ACULINA, LUNGU LIDIA, CIOCARLAN ALEXANDRU, VORNICU NICOLETA. Compus (1R,2R,8aS)-1-((5-mercapto-1,3,4-thiadiazol-2-il)metil)-2,5,5,8atetrametildecahidro nafthalen-2-ol cu proprietăţi antifungice şi antibacteriene. Patent Nr. 4580 C1, 28.02.2019, MD,  BOPI 1/2019.
  10. ARÎCU, A.; KUCHKOVA, K.; SECARA, E.; BARBA, A.; DRAGALIN, I.; UNGUR, N. Compusul 13-amino-14,15-dinorlabd-8(9)-enă pentru utilizare în calitate de remediu antimicotic. Patent Nr. 4573, MD, BOPI, 2018, (6).
  11. ROBU, Ș.; PRISACARI, V.; KULCIȚKI, V.; GRINCO, M.; BARBA, A. Polymeric Material with Antibacterial Properties Based on Lignin Grafted with N'-(5-nitrofurfurylidene) isonicotinehydrazide. Patent Nr 4506, BOPI, 2017, (8), p. 29.

National projects

  1. ANCD/20.80009.8007.03. New products with preventive and therapeutic potential basing on natural products of vegetal origin and modern methods of organic synthesis
    Period: 2020-2023
    Project manager: dr. habilitate, assoc. prof. Veaceslav KULCITKI
     
  2. CSSDT/15.817.02.14A. Elaboration of methods for obtaining valuable terpenoids by valorization of renewable resources from Republic of Moldova
    Period: 2015-2019
    Project manager: dr. habilitate, assoc. prof. Nicon UNGUR
     
  3. CSȘDT/16.00353.50.04A. Design, directed synthesis and study of antibacterial and antitumor activity of chiral terpenic compounds and their coordinative combinations with transition metals
    Period: 2016-2017
    Project manager: dr. habilitate, assoc. prof. Aculina ARICU
     

Bilateral projects

  1. AȘM-CNCI/18.80013.16.02.02/it. Synthesis of guanidine terpenoids with relevant biological activity and therapeutic potential
    Period: 2018-2019
    Project manager: Dr. habilitate, assoc. prof. Nicon UNGUR
     
  2. AȘM-STCU/18.80013.5007.01/6330STCU. Synthesis of biologically active norlabdanic compounds with heterocyclic structural units based on agricultural waste
    Period: 2018-2019
    Project manager: Dr. habilitate, assoc. prof. Aculina ARICU
     
  3. AȘM-ANCSI/16.80013.16.02.06/Ro. Directed synthesis and study of chiral complexes containing terpeno-heterocyclic ligands
    Period: 2016-2017
    Project manager: Dr. habilitate, assoc. prof. Aculina ARICU
     
  4. AȘM-STCU/15.820.18.03.07/5984STCU. Unconventional green processes for processing renewable raw materials
    Period: 2015-2017
    Project manager: Dr. habilitate, assoc. prof. Veaceslav KULCITKI
     
  5. AȘM-CNCI/15.820.16.02.02/it. Synthesis of guanidine terpenoids with relevant biological activity and therapeutic potential
    Period: 2015-2016
    Project manager: Dr. habilitate, assoc. prof. Nicon UNGUR
     

International project

  1. SCOPES/IZ73Z0-152346. Modification of natural compounds mediated by free radicals
    Period: 2015-2016
    Project manager: Dr. habilitate, assoc. prof.  Veaceslav KULCITKI

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