Anghel (Cazacu) Lilia

Title/degree Doctor 
Position Senior scientific researcher
Laboratory Physical and Quantum Chemistry
Office 220
Phone/fax (+373 22) 73 96 49
Email [email protected]
[email protected]
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Research areas

A qualified researcher, particularly interested in identifying the protein modifications induced by various extrinsic factors and understanding the relationship between the protein structure, dynamics and properties. Experienced in planning SANS and SAXS experiments, writing proposals and preparing suitable samples for small angle scattering experiments to study the protein structure in solution, protein conformation stability in solution, interaction of proteins in various systems, protein-protein interactions, protein-polyelectrolyte (polysaccharides) interactions.

Relevant publications
Projects
  1. Anghel, L., Rogachev A., Kuklin A., Erhan, R.V. β-Lactoglobulin associative interactions: a small angle scattering study. European Biophysics Journal (IF 2,219), 2019, 48: 285. https://doi.org/10.1007/s00249-019-01360-9
  2. Anghel, L., Radulescu, A., Bodnarchuk V.I., Erhan, R.V. Glucose oxidase from Aspargellius niger studied by small angle neutron scattering. European Conference on Neutron Scattering 2019. Saint-Petersburg, Russia. SCM-3, p. 546.
  3. Anghel, L., Kuklin A., Erhan, R.V. Wheat starch-protein interaction: effect of salt and temperature observed by small angle neutron scattering. Achievements and perspectives of modern chemistry, 2019, Chisinau, Republic of Moldova.
  4. Anghel, L., Radulescu, A., Erhan, R.V. Structural aspects of human lactoferrin in the iron binding process studied by molecular dynamics and small-angle neutron scattering. European Journal of Physics E – Soft Matter & Biological Physics (IF 0,861), 2018, 41:109, 7 p. DOI: 10.1140/epje/i2018-11720-x
  5. Duca, Gh., Anghel, L., Erhan, R.V. Structural aspects of lactoferrin and serum transferring observed by FTIR spectroscopy. Chemistry Journal of Moldova, 2018, 13(1), pp. 111-116. doi: http://dx.doi.org/10.19261/cjm.2018.482
  6. Anghel, L., Duca, Gh., Cepoi, L., Rudi, L., Erhan, R.V. The effects of operational parameters on the iron(III) uptake by micro-algae Dunaliella salina. Clean – Soil, Air, Water (IF 1.338), 46: 1800157. doi: https://doi.org/101002/clen.201800157
  7. Misco A., Anghel L., Duca Gh., The Influence of Tartaric Acid on Conformation and Stability of Human Serum Transferrin. Book of Abstracts. The VI International Conference on Ecological and Environmental Chemistry, March 2-3, 2017, Chisinau, Republic of Moldova, ISBN 978-9975-51-810-9, p. 216.
  8. Anghel Lilia, Raul Victor Erhan, Probing the β-lactoglobulin / polysaccharides interactions using small angle neutron scattering. Book of Abstracts. The International Conference „Condensed Matter Research at the IBR-2”, 9-12 October 2017, Dubna Moscow, Russian Federation, ISBN 978-5-9530-0480-0, p.69.
  9. Anghel L., Erhan R.V. Temperature and pH-dependent homo-association of beta-lactoglobulin studied by small angle neutron scattering technique. Book of Abstracts. The International Conference „Condensed Matter Research at the IBR-2”, 9-12 October 2017, Dubna Moscow, Russian Federation, ISBN 978-5-9530-0480-0, p.163. (Poster Presentation).
  10. Anghel L., Erhan R.V. Beta-lactoglobulin self-assembly: a small angle neutron scattering study. In: Book of Abstracts of the III International Conference on Small Angle Neutron Scattering dedicated to 80th anniversary of Yu. M. Ostanevich, Dubna, Russia, June 6-9, 2016, pp.76.
  11. Anghel L., Erhan R.V.Hetero-association of beta-lactoglobulin and sodium alginate  studied by small-angle neutron scattering. In: Book of Abstracts of the III International Conference on Small Angle Neutron Scattering dedicated to 80th anniversary of Yu. M. Ostanevich, Dubna, Russia, June 6-9, 2016, pp. 98.
  12. Anghel L. An investigation of the protonation states of human lactoferrin iron-binding protein. Chemistry Journal of Moldova, 2015, 10(1), p. 70-74. doi: http://dx.doi.org/10.19261/cjm.2015.10(1).10
  13. AnghelL., Erhan R.V., Duca Gh. Influence of tetrasodium ethylenediaminetetraacetate on binding capacity of human lactoferrin. In: Book of Abstracts of International Conference Condensed Matter Research at the IBR-2, Dubna, Russia, October 11-15, 2015, pp. 134-135.
  14. Anghel L., Erhan R.V. Molecular dynamics simulations and small angle X-ray scattering analysis of diferric human lactoferrin. In: Book of Abstracts XVIII-th Conference "Physical Methods in Coordination and Supramolecular Chemistry", Chisinau, Republic Moldova, October 8-9, 2015, pp. 34.
  15. Erhan R.V., AnghelL. Effects of chelating agents on conformational stability the protein lactoferrin. In: Book of Abstracts of the VIth European Conference on Neutron Scattering, Aragon Materials Science Institute, Zaragoza, Spain, August 30- September 4, 2015, ID: PS-1-24, 2015-09-01, pp.351.

National projects

  1. ANCD/20.80009.5007.27. Physico-chemical mechanisms of redox processes with electron transfer involved in vital, technological and environmental systems
    Period: 2020-2023
    Project manager: Acad., dr. habilitate, prof. Gheorghe DUCA
  2. CSSDT/15.817.02.02F. Study of mechanisms of chemical reactions, electronic structure and physico-chemical properties of transitiom-metal coordination compounds and nanoparticles A2B6
    Period: 2015-2019
    Project manager: Dr., assoc. prof. Natalia GORINCIOI


Internaționale

  1. H2020/CMCE-EU-RI. Development of international cooperation in the field of research “Water photolysis” (DCIDCPRFA)
    Period: 2015-2016
    Project manager: Academician, dr. habilitate, prof. Constantin TURTA / dr. habilitate, assoc. prof. Vasile LOZAN