Development of formulations against tomato phytopathogens based on autochthonous natural substances and their derivatives

The project is dedicated to obtaining formulations with antiviral, fungicidal and immunostimulating properties for their use in agriculture. The composition of thetargeted formulations will contain chitosan, a natural compound obtained from local sources - bee colonies, with the addition of different active substances of naturalor synthetic origin. The project will be carried out in 5 main stages and will include the synthesis of bioactive compounds, previously established by the project team(chitosan, spiro[cyclopropane-oxindoles], vinyltriazoles); preparing formulations for treating plants and establishing optimal concentrations of active substances inthem; determining the corelation between the bioactivity and the chemical structure of the compounds, and evaluating the structure of the substance with the highestpotential activity by quantum-chemical methods; synthesis of the compounds modeled by computational methods; establishing the optimal concentration of thesolutions of substances proposed for the treatment of plants. Moreover, in collaboration with the Institute of Genetics, Physiology and Plant Protection of USM,biological testing of the formulations obtained on plants will be carried out. The project will search for new and more effective drug candidates. Two strategies will beapplied to achieve this objective. First of all, formulations will be obtained with the content of the previously developed natural and synthetic products. Second, a newlibrary of mimetic derivatives will be obtained by computational prediction of the activity of new derivatives and their synthesis. Both strategies will use advancedapproaches to generate new bioactive formulations that deliver economic and social benefits. In the final stage of the announced project, the components of theformulations will be optimized to obtain the most promising ones and laboratory regulations will be developed to expand production for their use in agriculture for theprotection of plants against phytopathogens.