Girbu Vladilena

Title/degree Doctor
Position Scientific researcher
Laboratory Chemistry of Natural and Biologically Active Compounds
Office 304A
Phone/fax (+373 22) 73 97 69
Email [email protected]
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Research areas

Chemistry of natural products; radical chemistry: C-H functionalization; fluorination

Relevant publications
Projects

Articles

  1. Sîrbu, T.; Girbu, V.; Harghel, P.; Rusu, V.; Ungur, N. and Kulciţki, V. Selectivity Control in Terpene Rearrangements: A Biomimetic Synthesis of the Halimanic Bicyclic Core. Synthesis, 2019, 51, p. 1995-2000. DOI: 10.1055/s-0037-1610686.
  2. Grinco, M.; Girbu, V.; Gorincioi, E.; Barba, A.; Kulciţki, V.; Ungur, N. The First Biomimetic Synthesis of a Diterpenoid with the ent-Verrucosin A/B Skeleton. Tetrahedron Lett. 2016, 57 (19), pp. 2084-2086.
  3. Gîrbu, V. Funcționalizarea radicalică a legăturilor C-H în compușii naturali. In: Studia Universitatis Moldaviae, 2019, 6(116), p. 77-88. ISSN 1814-3237.
     

Abstracts

  1. Morărescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Unusual Remote C-H Functionalization of Manoyl Oxides. IUPAC International Symposium on Biiorganic Chemistry – ISBOC-11, 27-29 september 2017, Konstanz, Germany. Abstracts of communication, p. 145.
  2. Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Expanding Structural Diversity of ent-Kaurane Diterpenoids by Free Radical Chemistry. IUPAC International Symposium on Biiorganic Chemistry – ISBOC-11, 27-29 september 2017, Konstanz, Germany. Abstracts of communication, p. 149.
  3. Kulciţki, V.; Sîrbu, T.; Gîrbu, V.;  Ungur, N.; Rusu, V. A Biomimetic Synthesis of Halimanic Bicyclic Core. IUPAC International Symposium on Bioorganic Chemistry – ISBOC-11, 27-29 september 2017, Konstanz, Germany. Abstracts of communication, p. 136.
  4. Morărescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Unusual Remote C-H Functionalization of Manoyl Oxides by “Travelling” Radical. 2017 Villars Summer School “Trends in Organic Synthesis”. August 27-31, 2017 Villars-sur-Ollon, Switzerland. Abstracts of communication, p-14.
  5. Morărescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Structural Modification of ent-Kaurane Diterpenoidsby Atom Transfer Radical Additions. 2017 Villars Summer School “Trends in Organic Synthesis”. August 27-31, 2017 Villars-sur-Ollon, Switzerland. Abstracts of communication, p-28.
  6. Gîrbu, V.; Pruteanu, E.; Ungur, N.; Barbă, A.; Kulciţki, V. Terpene Ozonolysis In Green Solvents. The 6th International Conference Ecological & Environmental Chemistry-2017, March 2-3, 2017, Chisinau, Republic of Moldova. Abstracts of communication, p.229.
  7. Grinco, M.; Barbă, A.; Ungur, N.; Kulciţki, V. Lignin Ozonolysis In Deep Eutectic Solvents. The 6th International ConferenceEcological&Environmental Chemistry-2017, March 2-3, 2017, Chisinau, Republic of Moldova. Abstracts of communication, p.187-188.
  8. Gîrbu, V.; Pruteanu, E.; Ungur, N.; Barbă, A.; Kulciţki, V. Green solvents in natural product transformations. Terpene ozonolysis in dimethylcarbonate. XXXIV-th Romanian ChemistryConference, October 4-7, 2016, Călimăneşti-Căciulata, Vâlcea, Romania. Abstracts of communication, p.6.
  9. Grinco, M.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Barbă, A.; Kulciţki, V. Ozonolysis in deep eutectic solvents: fromterpenestolignin. XXXIV-th Romanian ChemistryConference, October 4-7, 2016, Călimăneşti-Căciulata, Vâlcea, Romania. Abstracts of communication, p.19.
  10. Gîrbu, V.; Grinco, M.; Ungur, N.; Kulciţki, V.; Renaud, P. Generating diversity in natural product scaffolds. Synthesis of ent-kauranic derivatives functionalized with triazole fragments. International symposium “Medicinal plants. Presentandperspectives”, september 6-9, 2016, Piatra Neamt, Romania. Abstracts of communication, p.144.
  11. Morarescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Towardsmimics of forskolin. Efficient free radical alkylations of manoyloxides. International symposium “Medicinal plants. Present and perspectives”, september 6-9, 2016, Piatra Neamt, Romania. Abstracts of communication, p.126.
  12. Pruteanu, E.; Gîrbu, V.; Ungur, N.; Kulciţki, V.; Renaud, P. Generatingdiversity in natural product scaffolds. Efficient C-17 alkylations of ent-kaur-16-enic derivatives. International symposium “Medicinal plants. Presentandperspectives”, september 6-9, 2016, Piatra Neamt, Romania. Abstracts of communication, p.88.
  13. Pruteanu, E.; Gîrbu, V.; Kulciţki, V. Utilizarea reacţiilor de olefinare a compușilor carbonilici în sinteza terpenoidelor. Conferința internațională „Viitorul ne aparține", Chișinău, Moldova, 6-7 octombrie 2016, Rezumate ale comunicărilor, p. 99.
  14. Girbu, V.; Grinco, M.; Kulciţki, V.; Renaud, P. Radicalichydroazidation of terpenoids. Synthesis of ent-kaurenoic derivatives functionalized with triazole fragments. International conference “Modern trends of scientificdevelopment: views of youngresearchers”, Chișinău, Moldova, 15 march 2016, Abstracts of communication, p. 81-85.
     

Patent

  1. Kulciţki, V.; Gîrbu, V.; Pruteanu, E.; Renaud, Ph.; Daelemans, D.; Mollo, E.; Defranoux, F.; Ungur, N. Methyl ent-17-amino-kauran-19-oate with selective cytotoxicactivity. Positive decision no. 9579 from 21.06.2019.  
 

National projects

  1. ANCD/20.80009.8007.03. New products with preventive and therapeutic potential basing on natural products of vegetal origin and modern methods of organic synthesis
    Period: 2020-2023
    Project manager: Dr. habilitate, assoc. prof.  Veaceslav KULCIȚKI 
     
  2. CSSDT/15.817.02.14A. Elaboration of methods for obtaining valuable terpenoids by valorization of renewable resources from Republic of Moldova
    Period: 2015-2019
    Project manager: Dr. habilitate, assoc. prof. Nicon UNGUR
     

International projects:

  1. SCOPES/IZ73Z0-152346. Modification of natural compounds mediated by free radical.
    Period: 2015-2016
    Project manager: Dr. habilitate, assoc. prof. Veaceslav KULCIȚKI 

  2. AȘM-STCU/15.820.18.03.07/5984STCU. Unconventional green processes for processing renewable raw materials.
    Period: 2015-2017;
    Project manager: Dr. habilitate, assoc. prof. Veaceslav KULCIȚKI