Kulcitki Veaceslav

Title/degree Doctor habilitate, assoc. prof.
Position Head of the Laboratory Chemistry of Natural and Biologically Active Compounds
Office 309
Phone/fax (+373 22) 73 97 75
Email [email protected]
[email protected]
Professional links

Scopus ID: 6506927017
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Research areas

Synthetic organic chemistry, chemistry of natural compounds, medicinal chemistry, analytical chemistry. Major contributions in the field of terpenoid chemistry, in particular:

  • Synthesis of diverse families of terpenic compounds according to the Random Biomimetic Principle;
  • Application of cationic rearrangements for skeletalmodifications of terpenoids;
  • Application of free radical transformations for the functionalization of terpenoids with heteroatoms;
  • SAR studies in the terpenoid series aimed to the identification of biologically active derivatives;
  • The use of HPLC, NMR and GC-MS methods for the analysis of secondary metabolites in vegetal sources;
  • Valorizing vegetal materials for the isolation of valuable secondary metabolites;

Implementation of Green Chemistry principles in the practical valorizing of natural products.

Publications
Projects

Didactic editions

  1. Veaceslav Kulcițki. Strategia sintezei organice. Principi generale și noțiuni fundamentale. Suport de curs. USDC, Departamentul Chimie, Matematică și Informatică. Chișinău, 2020. ISBN 978-9975-89-164-6. 94 p.
  2. Veaceslav Kulcițki. Istoria și evoluția cercetărilor în chimie. Suport de curs. USDC, Departamentul Chimie, Matematică și Informatică, Școala doctorală Științe Chimice și Tehnologice. Chișinău, 2019. ISBN 978-9975-108-98-0.114 p.
     

Articles

  1. Morarescu, O.; Grinco, M.; Kulciţki, V.; Barba, A.; Garbuz, O.; Gudumac, V.; Gulea, A.; Ungur, N. A Straightforward Synthesis of Natural Oxygenated ent-Kaurenoic Acid Derivatives. Synth. Commun. 2020, 50, (reg. LSYC-2020-14375), acceptatpentrupublicare.DOI: 10.1080/00397911.2020.1821225.
  2. Sîrbu, T.; Girbu, V.; Harghel, P.; Rusu, V.; Ungur, N. and Kulciţki, V. Selectivity Control in Terpene Rearrangements: A Biomimetic Synthesis of the Halimanic Bicyclic Core. Synthesis, 2019, 51, p. 1995-2000. DOI: 10.1055/s-0037-1610686.
  3. Grinco, M.; Girbu, V.; Gorincioi, E.; Barba, A.; Kulciţki, V.; Ungur, N. The First Biomimetic Synthesis of a Diterpenoid with the ent-Verrucosin A/B Skeleton. Tetrahedron Lett. 2016, 57 (19), pp. 2084-2086.
  4. Rusu, V.; Maftuleac, A.; Petuhov, O.; Kulciţki, V.; Grinco, M.; Postolachi, L.; Rusu M. Evaluarea proprietăţilor de suprafaţă ale bentonitului Lărguţa (Republica Moldova) intercalat cu oligomeri de aluminiu. Studia Universitatis Moldaviae-Științe Reale și ale Naturii, 2015, 1 (81), p. 178-185. 
     

Abstracts

  1. Гырбу, Владилена; Кульчицкий, Вячеслав; Унгур, Р.; Рено, Филипп. Функционализация дитерпеноидов посредством радикальных реакций. In: Современные достижения органической химии Школа молодых химиков государств-участников СНГ. 2-8 decembrie2019, Dușanbe. г. Душанбе, Республика Таджикистан: Академия наук Республики Таджикистан, 2019, p. 15.
  2. Морареску, Ольга; Гринько, Марина; Кульчицкий, Вячеслав; Унгур, Никон. Химическая модификация энт-каур-16-ен-19-овой и энт-трахилобан-19-овой кислот. In: Современныедостиженияорганическойхимии. Школа молодых химиков государств-участников СНГ. 2-8 decembrie 2019, Dușanbe. г. Душанбе, Республика Таджикистан: Академия наук Республики Таджикистан, 2019, p. 16.
  3. Gîrbu, Vladilena; Ungur, Nicon; Kulciţki, Veaceslav; Renaud, Philippe. Radical perfluoroalkylation of ent-kaurenoate derivatives. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: TipografiaAcademiei de Ştiinţe a Moldovei, 2019, p. 219. ISBN 978-9975-62-428-2.
  4. Gîrbu, Vladilena; Ungur, Nicon; Kulciţki, Veaceslav; Renaud, Philippe. Radical transformations of ENT-isocopalicditerpenes. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: TipografiaAcademiei de Ştiinţe a Moldovei, 2019, p. 220. ISBN 978-9975-62-428-2.
  5. Grinco, Marina; Gîrbu, Vladilena; Pruteanu, Elena; Morărescu, Olga; Kulciţki, Veaceslav; Ungur, Nicon. Synthesis of some guanidine diterpenoids. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: TipografiaAcademiei de Ştiinţe a Moldovei, 2019, p. 222. ISBN 978-9975-62-428-2.
  6. Morărescu, Olga; Grinco, Marina; Kulciţki, Veaceslav; Garbuz, Olga; Gudumac, Valentin; Ungur, Nicon. Synthesis of halogenated derivatives of ent-kaur-16-en-19-oic acid. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: TipografiaAcademiei de Ştiinţe a Moldovei, 2019, p. 246. ISBN 978-9975-62-428-2.
  7. Morărescu, Olga; Grinco, Marina; Kulciţki, Veaceslav; Ungur, Nicon. Synthesis of a C12-functionalized norscalarane from sclareol. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: TipografiaAcademiei de Ştiinţe a Moldovei, 2019, p. 230. ISBN 978-9975-62-428-2.
  8. Morărescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Unusual Remote C-H Functionalization of Manoyl Oxides. IUPAC International Symposium on Biiorganic Chemistry – ISBOC-11, 27-29 september2017, Konstanz, Germany. Abstracts of communication, p. 145.
  9. Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Expanding Structural Diversity of ent-KauraneDiterpenoids by Free Radical Chemistry. IUPAC International Symposium on Biiorganic Chemistry – ISBOC-11, 27-29 september2017, Konstanz, Germany. Abstracts of communication, p. 149.
  10. Kulciţki, V.; Sîrbu, T.; Gîrbu, V.;  Ungur, N.; Rusu, V. A Biomimetic Synthesis of Halimanic Bicyclic Core. IUPAC International Symposium on Bioorganic Chemistry – ISBOC-11, 27-29 september2017, Konstanz, Germany. Abstracts of communication, p. 136.
  11. Morărescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Unusual Remote C-H Functionalization of Manoyl Oxides by “Travelling” Radical. 2017 Villars Summer School “Trends in Organic Synthesis”. August 27-31, 2017 Villars-sur-Ollon, Switzerland. Abstracts of communication, p-14.
  12. Morărescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Structural Modification of ent-KauraneDiterpenoids by Atom Transfer Radical Additions. 2017 Villars Summer School “Trends in Organic Synthesis”. August 27-31, 2017 Villars-sur-Ollon, Switzerland. Abstracts of communication, p-28.
  13. Gîrbu, V.; Pruteanu, E.; Ungur, N.; Barbă, A.; Kulciţki, V. Terpene OzonolysisIn Green Solvents. The 6th International Conference Ecological & Environmental Chemistry-2017, March 2-3, 2017, Chisinau, Republic of Moldova. Abstracts of communication, p.229.
  14. Grinco, M.; Barbă, A.; Ungur, N.; Kulciţki, V. Lignin OzonolysisIn Deep Eutectic Solvents. The 6th International Conference Ecological & Environmental Chemistry-2017, March 2-3, 2017, Chisinau, Republic of Moldova. Abstracts of communication, p.187-188.
  15. Kulciţki, V. Ozonolysis of Alkenes: Transformations Far Beyond C=C Cleavage. The 6th International Conference Ecological & Environmental Chemistry-2017, March 2-3, 2017, Chisinau, Republic of Moldova. Abstracts of communication, p.190-191.
  16. Gîrbu, V.; Pruteanu, E.; Ungur, N.; Barbă, A.; Kulciţki, V. Green solvents in natural product transformations. Terpene ozonolysis in dimethylcarbonate. XXXIV-th Romanian Chemistry Conference, October 4-7, 2016, Călimăneşti-Căciulata, Vâlcea, Romania. Abstracts of communication, p.6.
  17. Grinco, M.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Barbă, A.; Kulciţki, V. Ozonolysis in deep eutectic solvents: from terpenes to lignin. XXXIV-th Romanian Chemistry Conference, October 4-7, 2016, Călimăneşti-Căciulata, Vâlcea, Romania. Abstracts of communication, p.19.
  18. Gîrbu, V.; Grinco, M.; Ungur, N.; Kulciţki, V.; Renaud, P. Generating diversity in natural product scaffolds. Synthesis of ent-kauranic derivatives functionalized with triazole fragments. International symposium “Medicinal plants. Present and perspectives”, september 6-9, 2016, Piatra Neamt, Romania. Abstracts of communication, p.144.
  19. Morarescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Towards mimics of forskolin. Efficient free radical alkylations of manoyloxides. International symposium “Medicinal plants. Present and perspectives”, september 6-9, 2016, Piatra Neamt, Romania. Abstracts of communication, p.126.
  20. Pruteanu, E.; Gîrbu, V.; Ungur, N.; Kulciţki, V.; Renaud, P. Generating diversity in natural product scaffolds. Efficient C-17 alkylations of ent-kaur-16-enic derivatives. International symposium “Medicinal plants. Present and perspectives”, september 6-9, 2016, Piatra Neamt, Romania. Abstracts of communication, p.88.
  21. Pruteanu, E.; Gîrbu, V.; Kulciţki, V. Utilizarea reacţiilor de olefinare a compușilor carbonilici în sinteza terpenoidelor. Conferința internațională „Viitorul ne aparține", Chișinău, Moldova, 6-7 octombrie 2016, Rezumate ale comunicărilor, p. 99.
  22. Girbu, V.; Grinco, M.; Kulciţki, V.; Renaud, P. Radicalic hydroazidation of terpenoids. Synthesis of ent-kaurenoic derivatives functionalized with triazole fragments. International conference “Modern trends of scientific development: views of young researchers”, Chișinău, Moldova, 15 march 2016, Abstracts of communication, p. 81-85.
  23. Harghel, P.; Grinco, M.; Ungur, N. and Kulcitki, V. Synthesis of highly functionalized perhydrindanic units by a degradation-cyclization approach. 16th Tetrahedron Symposium, june 2015, Berlin, Germany. Abstracts of communication, P3-143.
     

Patents

  1. Robu, Ş.; Prisacari, V.; Kulciţki, V.; Grinco, M.; Barba, A. Polymeric material with antibacterial properties based on lignin grafted with N'-(5-nitrofurfurylidene) isonicotinehydrazide. Patent of Republic of Moldova no 4506, BOPI, 2017, (8), 29.
  2. Kulciţki, V.; Gîrbu, V.; Pruteanu, E.; Renaud, Ph.; Daelemans, D.; Mollo, E.; Defranoux, F.; Ungur, N. Methyl ent-17-amino-kauran-19-oate with selective cytotoxic activity. Positive decision no. 9579  from 25.08.2020.

National projects

  1. ANCD/20.80009.8007.03. New products with preventive and therapeutic potential basing on natural products of vegetal origin and modern methods of organic synthesis
    Period: 2020-2023
    Project manager: dr. habilitat Veaceslav KULCIȚKI 
     
  2. CSSDT/15.817.02.14A. Elaboration of methods for obtaining valuable terpenoids by valorization of renewable resources from Republic of Moldova
    Period: 2015-2019
    Project manager: dr. habilitate, assoc. prof. Nicon UNGUR
     

International projects:

  1. AȘM-CNCI/15.820.16.02.02/it. Synthesis of guanidine terpenoids with relevant biological activity and therapeutic potential.
    Period: 2015-2016;
    Project manager: Dr. habilitate, assoc. prof. Nicon UNGUR

  2. AȘM-CNCI/18.80013.16.02.02/it. Synthesis of guanidine terpenoids with relevant biological activity and therapeutic potential.
    Period: 2018-2019;
    Project manager: Dr. habilitate, assoc. prof. Nicon UNGUR

  3. SCOPES/IZ73Z0-152346. Modification of natural compounds mediated by free radicals
    Period: 2015-2016
    Project manager: Dr. habilitate, assoc. prof.  Veaceslav KULCITKI

  4. AȘM-STCU/15.820.18.03.07/5984STCU. Unconventional green processes for processing renewable raw materials.
    Period: 2015-2017;
    Project manager: Dr. habilitate, assoc. prof. Veaceslav KULCITKI