Ciocarlan Alexandru

Title/degree Doctor, assoc. prof.
Position Leading scientific researcher 
Laboratory Chemistry of Natural and Biologically Active Compounds
Office 304
Phone/fax (+373 22) 73 97 69
Email [email protected]
[email protected]
Professional links

Google scholar 
ORCID   
ResearchGate
Scopus Author ID
IBN
AGEPI

Research areas
  • Bioorganic chemistry. Chemistry of natural and biologically active compounds.
  • Isolation of secondary metabolitesfrom native plants and vegetal by-products using various techniques.
  • Synthesisof new polyfunctionalizedterpenic derivatives or of natural products analogs using conventional and non-conventional methods.
  • Structure elucidationby modern analytical methods.
Relevant publications
Projects

Articles in international journals (Web of Science and SCOPUS)

  1. CIOCARLAN, A., DRAGALIN, I., ARICU, A., LUPASCU, L., CIOCARLAN, N., VERGEL, K., DULIU, O.G., HRISTOZOVA, G., ZINICOVSCAIA, I. Chemical profile, elemental composition, and antimicrobial activity of plants of the Teucrium (Lamiaceae) genus growing in Moldova. In: Agronomy, 2022, 12(4), 772-788.  DOI: https://doi.org/10.3390/agronomy12040772 (FI 2.24)
  2. CIOCARLAN, A., LUPASCU, L., ARICU, A., DRAGALIN, I., POPESCU, V., GEANA, E.I., IONETE, R.E., VORNICU, N., DULIU, O.G., HRISTOZOVA, G., ZINICOVSCAIA, I. Chemical composition and assessment of antimicrobial activity of lavender essential oil and some by-products. In: Plants, 2021, 10(9), 1829-1843. DOI: https://doi.org/10,3390/plants1091829 (FI 3.935). IBN: https://ibn.idsi.md/ro/vizualizare_articol/138166
  3. URECHE, D., BULHAC, I., CIOCARLAN, A., ROSHCA, D., LUPASCU, L., BOUROSH, P. Novel vic-Dioximes: synthesis, structure characterization and antimicrobial activity evaluation. In: Turkish Journal of Chemistry, 2021, 45(6), 1873-1881. DOI: 10.3906/kim-2104-24 (IF 1.239). IBN: https://ibn.idsi.md/ro/vizualizare_articol/148592
  4. CIOCARLAN, A., HRISTOZOVA, G., ARICU, A., DRAGALIN, I., ZINICOVSCAIA, I., YUSHIN, N., GROZDOV D., POPESCU, V. Determination of the elemental composition of aromatic plants cultivated industrially in the Republic of Moldova using neutron activation analysis. In: Agronomy, 2021, 11(5), 1011-1030.  DOI: 10.3390/agronomy11051011 (IF 2.603). IBN: https://ibn.idsi.md/ro/vizualizare_articol/132488
  5. GEANĂ, E.-I., CIUCURE, C.T., IONETE, R.E., CIOCARLAN, A., ARICU, A., FICAI, A., ANDRONESCU, E. Profiling of phenolic compounds and triterpene acids in different apple (Malus domestica Borkh.) cultivars. In: Foods, 2021, 10(2), 267-282. DOI: https://doi.org/10.3390/foods10020267 (FI 4.350). IBN: https://ibn.idsi.md/ro/vizualizare_articol/126448
  6. BLAJA, S.P., LUNGU, L.V., KUCHKOVA, K.I., CIOCARLAN, A.G., BARBA, A.N., VORNICU, N., ARICU, A.N. Norlabdane compounds containing thiosemicarbazone or 1,3-thiazole fragments: Synthesis and antimicrobial activity. In: Chemistry of Natural Compounds, 2021, 57(1), 101-110. DOI: https://doi.org/10.1007/s10600-021-03292-3 (FI 0.809).  IBN: https://ibn.idsi.md/ro/vizualizare_articol/126852
  7. CIOCARLAN, A., LUPASCU, L., ARICU, A., DRAGALIN, I., CIOCARLAN, N., ZINICOVSCAIA, I., SLANINA, V., YUSHIN, N. Chemical composition of the essential oil and antimicrobial properties of crude extract from Tanacetum corymbosum (L.). In: Chemistry Journal of Moldova, 2021, 16(2), 83-90.  DOI: 10.19261/cjm.2021.877. IBN: https://ibn.idsi.md/ro/vizualizare_articol/146807
  8. CIOCARLAN, A. (+)-Larixol and larixyl acetate: syntheses, phytochemical studies and biological activity assessments. In: Chemistry Journal of Moldova. 2021, 16, (1), pp. 30-45. DOI: https://doi.org/10.19261/cjm.2021.836. IBN: https://ibn.idsi.md/ro/vizualizare_articol/134251
  9. LUNGU, L., CIOCARLAN, A., SMIGON, C., OZER, I., SHOVA, S., GUTU, I., VORNICU, N., MANGALAGIU, I., D'AMBROSIO, M., ARICU, A.. Synthesis and evaluation of biological activity of homodrimane sesquiterpenoids bearing 1,3,4-oxadiazole or 1,3,4-thiadiazole units. In: Chemistry of Heterocyclic Compounds, 2020, 56(5), 578-585.  DOI: 10.1007/s10593-019-02526-1. (IF 1.492). IBN: https://ibn.idsi.md/ro/vizualizare_articol/107236
  10. ZINICOVSCAIA, I., GUNDORINA, S., VERGEL, K., GROZDOV, D., CIOCARLAN, A., ARICU, A., DRAGALIN, I., CIOCARLAN, N. Elemental analysis of Lamiaceae medicinal and aromatic plants growing in the Republic of Moldova using neutron activation analysis. In: Phytochemistry Letters, 2020, 35, 119-127.  DOI: 10.1016/j.phytol.2019.10.009 (IF 1.338)
  11. CIOCARLAN, A., LUNGU, L., BLAJA, S., DRAGALIN, I., ARICU, A. The use of some non-conventional methods in chemistry of bicyclohomofarnesenic methyl esters. In: Chemistry Journal of Moldova, 2020, 15(2), 69-77. DOI: https://doi.org/10.19261/cjm.2020.791. IBN: https://ibn.idsi.md/ro/vizualizare_articol/118145

Articles  in abstract books

  1. ARÎCU, A., LUNGU, L., BLAJA, S., CUCICOVA, C., CIOCÂRLAN, A. Sinteza și studiul activității antimicrobiene a compușilor norlabdanici cu unități structurale heterociclice. In: Acad. A. Gulea - Conferinţa Ştiinţifică Naţională cu participare Internaţională: „Materiale Avansate în Biofarmaceutică şi Tehnică”, Culegere de articole, Chişnău, 2021, p. 10-34.
  2. ARICU, A., CIOCARLAN A. Synthesis of biologically active terpenoids by valorisation of some vegetable wastes. IN: Conference "Ecological and environmental chemistry 2022" 7th Edition, Chisinau, Moldova, 3-4 March 2022. In: Ecological and environmental chemistry, Vol. 1, p. 146-147, 2022. IBN: https://ibn.idsi.md/ro/vizualizare_articol/151942

 Abstracts

  1. CIOCARLAN, A., BLAJA, S., CUCICOVA, C., LUNGU, L., ARICU, A. Synthesis of some new homodrimane sesquiterpenoids with benzothiazole fragment. In: The 21st Tetrahedron Symposium – Online, 21 – 24 June 2021. (Reg. numb. ETR2021_0478). https://app.oxfordabstracts.com/events/1644/secure/program-app/submission/241532
  2. LUNGU, L., BLAJA, S., CIOCARLAN, A., DRAGALIN, I., ARICU, A. The electrochemical transformations of methyl bicyclohomofarnesoates. In: New frontiers in natural product chemistry. Online scientific seminar, Chisinau, June 4, 2021, Book of Abstracts, p. 15.  DOI: https://doi.org/10.19261/nfnpc.2021.ab08. IBN: https://ibn.idsi.md/ro/vizualizare_articol/131092
  3. CIOCÂRLAN, A., CAZACU, V., LUNGU, L., BLAJA, S., DRAGALIN, I., ARÎCU, A. The use of non-conventional methods for the isolation of chromatographically inseparable compounds. In: New frontiers in natural product chemistry. Online scientific seminar, Chisinau, June 4, 2021, Book of Abstracts, p. 19.  DOI: https://doi.org/10.19261/nfnpc.2021.ab12. IBN: https://ibn.idsi.md/ro/vizualizare_articol/131096
  4. POPESCU, V., CIOCARLAN, A., DRAGALIN, I., LUNGU, L., ARÎCU, A. Chemical composition of essential oil of Dill (Anethum graveolens L.) growing in Republic of Moldova. In: New frontiers in natural product chemistry. Online scientific seminar, Chisinau, June 4, 2021, Book of Abstracts, p. 35.  DOI: https://doi.org/10.19261/nfnpc.2021.ab28. IBN: https://ibn.idsi.md/ro/vizualizare_articol/13114.
  5. CIOCARLAN, A. Valorisation of some terpenes from vegetable wastes. International Conference “Intelligent Valorisation of Agro-Industrial Wastes”, 07-08 October 2021, Chisinau, Republic of Moldova. IBN: https://ibn.idsi.md/ro/vizualizare_articol/140156

Patents

  1. ARÎCU, A., CIOCÂRLAN, A., LUNGU, L., BLAJA, S., VORNICU, N. 5-(Homodrim-6,8-dien-11-il)-1,3,4-tiadiazol-2(3H)-imină cu proprietăţi antifungice. Patent MD 4765.
  2. ARÎCU, A., CIOCÂRLAN, A., LUNGU, L., BLAJA, S., VORNICU, N. (Z/E)-2-(1-((1R,2R,8aS)-2-hidroxi-2,5,5,8a-tetrametildecahidronaftalen-1-il)propan-2-iliden)hidra- zincarbotioamidă pentru utilizare în calitate de remediu antifungic. Patent MD 4769.
  3. ARÎCU, A., CIOCÂRLAN, A., LUNGU, L., BLAJA, S., VORNICU, N. 5-(Homodrim-6,8-dien-11-il)-1,3,4-tiadiazol-2(3H)-imină cu proprietăţi antifungice. Salonul internațional de invenții și inovații „TRAIAN VUIA” ediția a VII-a, 06-08 octombrie 2021, Timișoara. Gold Medal.
  4. ARÎCU, A., LUNGU, L., CIOCÂRLAN, A., BLAJA, S., VORNICU, N. Compușii terpenici noi cu fragment tiadiazolic/tiosemicarbazonic cu proprietăți antifungice. EIS „INFOINVENT”, ediția a XVII-a, 17-20 noiembrie 2021, Chișinău. Gold Medal.

National projects

  1. ANCD/20.80009.8007.03. New products with preventive and therapeutic potential basing on natural products of vegetal origin and modern methods of organic synthesis
    Period: 2020-2023
    Project manager: Dr. habilitate Veaceslav KULCIȚKI 
  2. CSSDT/15.817.02.14A. Elaboration of methods for obtaining valuable terpenoids by valorization of renewable resources from Republic of Moldova
    Period: 2015-2019
    Project manager: Dr. habilitate, assoc. prof. Nicon UNGUR
  3. CSȘDT/16.00353.50.04A. Design, directed synthesis and study of antibacterial and antitumor activity of chiral terpenic compounds and their coordinative combinations with transition metals
    Period: 2016-2017
    Project manager: Dr. habilitate, assoc. prof. Aculina ARICU
     

Internațional projects

  1. AȘM-STCU/18.80013.5007.01/6330STCU. Synthesis of biologically active norlabdanic compounds with heterocyclic structural units based on agricultural waste.
    Period: 2018-2019;
    Project manager: Dr. habilitate, assoc. prof. Aculina ARICU