Aricu Aculina

Title/degree Doctor habilitate, assoc. prof.
Position Director;
Head of the Centre Applied Organic Chemistry;
Principal scientific researcher in Laboratory of Chemistry of Natural and Biologically Active Compounds
Office 322
Phone/fax (+373 22) 72 54 90
Email aculina.aricu @ sti.usm.md
aculina.aricu @ gmail.com
aculina.aricu @ ichem.md
Professional links

Scopus Author ID
ORCID ID 
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IBN
AGEPI
Research areas

Organic and bioorganic chemistry; chemistry of natural and physiologically active compounds; elaboration of chemo-, regio- and stereoselective methods of the synthesis of optically active norlabdanic and drimanic compounds, including nitrogen and halogen-containing derivatives, as well as terpeno-heterocyclic hybrid compounds on the basis of accessible natural labdane diterpenoid sclareol; the elucidation of reaction mechanisms and optimal conditions of obtaining the mentioned compounds; the targeted synthesis of new compounds with high  the potential of biological activity, with the application of computational methods for forecasting activity, with further possibilities for industrial applications.

Relevant publications
Projects

Chapters in monographs

  1. A.Aricu, N.Ungur, Gh. Duca, Design, Targeted Synthesis and Study of Biological Activity of Some Polifuntional Chiral Terpenic Compounds. Compounds and Materials for Drug Development and Biomedical Applications. Ed. Academiei Române- Editura Istros a Muzeului Brăilei „Carol I”, 2018. ISBN 978-973-27-2944-1, ISBN 978-606-654-297-5.
  2. Ungur, N.; Aricu, A.; Grinco, M. Occurrence, Biological Activity and Synthesis of Diterpenoid Amides. Diterpenoids. Types, Functions and Research. Brandon Jones ed., Nova Science Publishers, Inc.,  New York, 2017, PP. 1-30. ISBN: 978-1-53610-671-8.


Articles 

  1. Amariucai-Mantu D. , Mangalagiu V., Bejan I, Aricu A. And Mangalagiu I. I., Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy,  Pharmaceutics 2022, 14, 2026-2046. 
  2. Ciocarlan A., Hristozova G., Aricu A., Dragalin I., Zinicovscaia I., Yushin N., Grozdov D., Popescu V. Determination of the elemental composition of aromatic plants cultivated industrially in the Republic of Moldova using neutron activation analysis. Agronomy, 2021, 11, 1011-1030.
  3. Ciocarlan A., Lupascu L., Aricu A., Dragalin I., Popescu V., Geana E.-I., Ionete R.E., Vornicu N., Duliu O.G. Hristozova G., Zinicovscaia I. Chemical composition and assessment of antimicrobial activity of Lavender essential oil and some by-products. Plants, 2021, 10, 1829-1843.
  4. Geană E.-I., Ciucure C.T., Ionete R.E., Ciocarlan A., Aricu A., Ficai A., Andronescu E. Profiling of phenolic compounds and triterpene acids in different apple (Malus domestica Borkh.) cultivars. Foods, 2021, 10(2), 267-282.
  5. Blaja S.P., Lungu L.V., Kuchkova K.I., Ciocarlan A.G., Barba A.N., Vornicu N., Aricu A.N. Norlabdane compounds containing thiosemicarbazone or 1,3-thiazole fragments: Synthesis and antimicrobial activity. Chemistry of Natural Compounds. 2021. nr. 57, p. 101-110.
  6. Lungu L., Cucicova C., Blaja S., Ciocarlan  A., Dragalin  I., Vornicu  N., Geana  E., Mangalagiu I.I., Aricu A.  Synthesis of homodrimane sesquiterpenoids bearing 1,3-benzothiazole unit and their Antimicrobial activity evaluation Molecules 2022, 27, 5082-96.  
  7. Ciocarlan A., Dragalin I., Aricu A., Lupascu L., Ciocarlan N., Vergel K., Duliu O.G., Hristozova G., Zinicovscaia I. Chemical profile, elemental composition, and antimicrobial activity of plants of the Teucrium (Lamiaceae) genus growing in Moldova. In: Agronomy, 2022, 12(4), 772-788.
  8. Lungu L., Cucicova C., Blaja S., Ciocarlan A., Dragalin I., Barba A., Kulcițki V., Vornicu V., Geana E., Mangalagiu I. I., Aricu A. Synthesis and antimicrobial activity evaluation of homodrimane sesquiterpenoids with benzimidazole unit. Molecules 2023, nr. 3(28), pp. 1-14.
  9. Kuchkova K., Aricu A., Secara E., Barba A., Vlad P., Macaev F., Melnic E., Kravtov V. Synthesis and structure of homodrimanic sesquiterpenoids containing 1,2,4-triazole and carbazolerings. Chem. Nat. Compd., 2015, vol. 51,  Nr 4p. 684-688.
  10. Aricu A., Ciocarlan A., Lungu L., Barba A., Shova S., Zbancioc G., Mangalagiu I. I, D’Ambrosio M., Vornicu N. Synthesis, antibacterial, and antifungal activities of new drimane sesquiterpenoids with azaheterocyclic units. In: Med. Chem. Res, 2016, vol. 25, nr. 10, p. 2316-2323. DOI: 10.1007/s00044-016-1665-0 (IF=1.436)
  11. Aricu A. N., Kuchkova K. I., Barba A. N., Dragalin I. P., Shova S. G., Vornicu N., Gorinchoi E. K., Sekara E. S., Lungu L. V., Niculaua M., Ungur N. D., Vlad P. F., Synthesis from norambreinolide, structure, and antimicrobial activity of dihomodrimane sesquiterpenoids with azine, hydrazide, and dihydrazide fragments. In: Chem. Nat. Comp., 2016, vol. 52, nr. 6, p. 1029-1036. DOI: https://doi.org/10.1007/s10600-016-1854-6 (I.F. 1.029).
  12. Dragalin I., Aricu A., Ciocarlan N., Ciocarlan A., Codita V. GC-MS analysis of the essential oil of Satureja subspicata BARTL. EX VIS. of Moldovan origin. In: Chem. J. of Moldova, 2016, vol. 11, nr. 2, p. 105-108. DOI: https://doi.org/10961/cjm.2016.11(2).06.
  13. Ciocarlan A., Aricu A., Lungu L., Edu C., Barba A., Shova S., Mangalagiu I. I., D’Ambrosio M., Nicolescu A., Deleanu C., Vornicu N. Synthesis of novel tetranorlabdane derivatives with unprecedented carbon skeleton. In: Synlett, 2017, vol. 28, nr, 05, p. 565–571. DOI: https://doi.org/10.1055/s-0036-1588651. ISSN 1437-2096 (IF: 2.32).
  14. Aricu A. N., Kuchkova K. I., Sekara E. S., Barba A. N., Dragalin I. P., Ungur N. D., Melnic E., Kravtsov V.Kh. Synthesis and structure of drimane sesquiterpenoids containing diazine, 1,2,4-triazole and carbazole rings. In: Chem. Nat. Comp., 2018, vol. 54, nr. 3, p. 455-460. DOI: https://doi.org/10.1007/s10600-018-2378-z.
  15. Duca Gh., Aricu A., Lungu L., Tenu N., Ciocarlan A., Gutu Y., Dragalin I., Barba A. Synthesis of new homodrimane sesquiterpenoids containing diazine, 1,2,4-triazole and carbazole rings. In: Chem. J. Mold., 2018, vol. 13, nr.1, p. 69-73. DOI: http://dx.doi.org/10.19261/cjm.2017.458.
  16. Ciocarlan A., Dragalin I., Aricu A., Ciocarlan N., Stavarache C., M. Deleanu. Chromatographic analysis of Silybum Marianum (L.) Gaertn. Fatty oil. In: Chem. J. of Moldova, 2018, vol. 13, nr. 1, p. 63-68. DOI: http://dx.doi.org/10.19261/cjm.2018.484 . 
  17. Alexandru Ciocarlan, Ion Dragalin, Aculina Aricu, Lucian Lupascu, Nina Ciocarlan, Violeta Popescu, Chemical composition and antimicrobial activity of the Levisticum officinale W.D.J. Koch essential oil, Chem. J. Mold, 2018, 13(2), 63-68. DOI: http://dx.doi.org/10.19261/cjm.2018.514 .
  18. Michele D'Ambrosio, Alexandru Ciocarlan, Aculina Aricu, Minor acetylated metabolites from Euphrasia rostkoviana. Natural and synthetic acetylated derivatives of rutin. Nat. Prod. Res., 2018, 34(2), 290. https://doi.org/10.1080/14786419.2018.1530227.
  19. Lungu, Lidia; Ciocarlan, Alexandru; Barbă, Alic; Shova, Sergiu; Pogrebnoi, Serghei; Mangalagiu, Ionel; Moldoveanu, Costel; Vornicu, Nicoleta; Ambrosio, Michele; Babak, Maria V.; Arion, Vladimir; Aricu, Aculina. Synthesis and Evaluation of Biological Activity of Homodrimane Sesquiterpenoids Bearing Hydrazinecarbothioamide or 1,2,4-Triazole Unit. In: Chemistry of Heterocyclic Compounds. 2019, 55(8), pp. 716-724. ISSN 0009-3122. DOI:  https://doi.org/10.1007/s10593-019-02526-1.
  20.  Duca, Gheorghe; Aricu, Aculina; Kuchkova, Kaleria; Secara, Elena; Barbă, Alic; Dragalin, Ion; Ungur, Nicon; Spengler, Gabriella. Synthesis, structural elucidation and biological evaluations of new guanidine-containing terpenoids as anticancer agents. In: Natural Product Research. 2019, nr. 21(33), pp. 3052-3056. ISSN 1478-6419. DOI: https://doi.org/10.1080/14786419.2018.1516658.
  21. Zinicovscaia, Inga; Ciocarlan, Alexandru; Lupaşcu, Lucian; Aricu, Aculina; Dragalin, Ion; Ciocarlan, Nina; Yushin , Nikita. Chemical analysis of Tanacetum corymbosum (L.) Sch. Bip. using neutron activation analysis. In: Journal of Radioanalytical and Nuclear Chemistry. 2019, nr. 1(321), pp. 349-354. ISSN 0236-5731.
  22. Aricu, Aculina; Nastas, Raisa; Cocu, Maria. The institute of chemistry at 60 years anniversary. brief history, achievements and perspectives. In: Chemistry Journal of Moldova. 2019, nr. 1(14), pp. 8-31. ISSN 1857-1727. DOI: https://doi.org/10.19261/cjm.2019.349.
  23. Antoci, V.; Cucu, D.; Zbancioc, Ghe.; Moldoveanu, C.; Mangalagiu, V.; Amariucai-Mantu, D.; Aricu, A; Mangalagiu, I.I. Bis-(imidazole/benzimidazole)-pyridine derivatives: synthesis, structure and antimycobacterial activity. Part XII, Future Medicinal Chemistry, 12(3), 207-222, 2020. DOI: https://doi.org/10.4155/fmc-2019-0063. (IF.3.841).
  24. Zinicovscaia Inga, Gundorina Svetlana, Vergel Constantin, Grozdov Dmitrii , Ciocarlan Alexandru, Aricu Aculina , Dragalin Ion , Ciocarlan Nina. Elemental analysis of Lamiaceae medicinal and aromatic plants growing in the Republic of Moldova using neutron activation analysis,  Phytochemistry Letters. 2020, nr.35, pp. 119–127.( I.F. 1.338).
  25. Lungu L., Ciocarlan A., Smigon C., Ozer I., Shova S., Gutu I., Vornicu N., Mangalagiu I., D'ambrosio M., Aricu A.. Synthesis and evaluation of biological activity of homodrimane sesquiterpenoids bearing 1,3,4-oxadiazole or 1,3,4-thiadiazole units.  Chemistry of Heterocyclic Compounds, 2020, 56(5), 578-585. DOI: https://doi.org/10.1007/s10593-020-02703-7. ( I.F. 1.492).
  26. Aricu A.N., Kuchkova K.I., Secara-Cushnir E.S., Barba A.N., Ungur N.D. Synthesis and Antimicrobial Activity of New Drimane and Homodrimane Sesquiterpenoids with Oxadiazole and Thiadiazole Fragments. Chemistry of Natural Compounds 2020, 56(4), 656-662. DOI: https://doi.org/10.1007/s10600-020-03115-x ( I.F. 1.029).
     

Materials of scientific communications

  1. Nina Ciocarlan, Alexandru Ciocarlan, Ion Dragalin, Aculina Aricu, Inga Zinicovscaia, Svetlana Gundorina. GC–MS and neutron activation (NAA) analysis of medicinal Teucrium L. species. Progress of Cryogenics and Isotop Separation. The 22nd National Conference with International Participation “New Cryogenic and Isotope Technologies for Energy and Environment”. EnergEn 2018. Baile-Govora, Romania, 24-26 October, 2018, V. 21(2), p. 121-129.
  2. Arîcu A., Kulcițki V., Ungur N. Sclareolul – Materie Primă Sustenabilă Pentru Sinteza Compușilor Terpenici cu Valoare Adăugată Înaltă. În monografia: Chimie ecologică: istorie și realizări,  dedicată academicianului  Gheorghe DUCA cu ocazia împlinirii a 70 de ani de la naștere. Chişinău: 2022, pp. 86-113. ISBN 978-9975-159-05-0. https://ibn.idsi.md/vizualizare_articol/164444.
  3. Aricu A., Ciocarlan A. Synthesis of biologically active terpenoids by valorization of some vegetable wastes. In: International Conference "Ecological and environmental chemistry 2022", 7th Edition, Chisinau, Moldova, 3-4 March 2022, vol. 1, pp. 146-147.
     

Abstracts of scientific communications

  1. Lungu L. A. Ciocarlan; A. Aricu; G. Zbancioc; I. Mangalagiu; N. Vornicu; S. Shova. Synthesis, Biological Activity and X-Rays Analysis of 11,12-P-Tolyl-pyridazonyl-drim-5(6),8(9)-en-7-one. In: The XVIII-th Conference “Physical Methods in Coordination and Supramolecular Chemistry”, Chisinau, R. Moldova, 2015, p. 93.
  2. A. Ciocarlan; M. Stroncea; A. Aricu; L Lungu; N. Vornicu; M. D’Ambrosio. New Antifungal and Antibacterial Activities of Lagochilin and its Derivatives. In: The XVIII-th Conference “Physical Methods in Coordination and Supramolecular Chemistry”, Chisinau, R. Moldova, 2015, p. 50.
  3. Rudic V., Arîcu A., Cucicova C., Cepoi L., Rudi L., Codreanu S., Secara E., Valuța A., Barbă A., Miscu V., Vlad P., Chiriac T. Using of new hybrid  compounds with terpenoid and  azaheterociclic skeleton  to increase I antioxidant activity of the Nostoc Linckia. In:  The XVIII-th Conference “Physical Methods in Coordination and Supramolecular Chemistry”, Chisinau, R. Moldova, 2015, p. 130.
  4. Aricu A.N., Kuchkova K.I., Barba A.N., Gorincioi E.C., Dragalin I.P., Ungur N.D., Vlad P.F. Synthesis  of  11-dihomodriman-8a-ol-12-one derivatives with azine and  hydrazide fragments. In: The XVIII-th Conference “Physical Methods in Coordination and Supramolecular Chemistry”, Chisinau, R. Moldova, 2015, p. 36.
  5. Aricu A.N., Kuchkova K.I., Barba A.N., Secara E.S., Dragalin I.P., Ungur N.D., Vlad P.F. Synthesis of 8,9-bicyclohomofarnesenic acid guanidine derivatives from norambreinolide.  In: The XXXIV-th Romanian Chemistry Conference, Calimanesti-Caciulata, Romania, 2016, p. 9.
  6. Aricu A.N., Kuchkova K.I., Barba A.N., Secara E.S., Dragalin I.P., Ungur N.D., Vlad P.F. Synthesis of guanidine derivatives of 12-amino-11-dihomodrimane-8α-ol and 13-amino-14,15-dinorlabd-8(9)-ene. In: The XXXIV-th Romanian Chemistry Conference, Calimanesti-Caciulata, Romania, 2016, p. 22.
  7. Lungu L., Șmigon C., Aricu A., Ciocarlan A., Barba A., Shova S. Synthesis and X-ray analysis of new tetranorlabdane compound with thiadiazole unit. In: The 8th International Conference on Materials Science and Condensed Matter Physics. Chisinau, R. Moldova, 2016, p.151.
  8. Lungu L., Aricu A., Ciocarlan A., Barba A., Vornicu N. Synthesis of new biological active tetranorlabdane compounds with triazole units. In: The XXXIV-th Romanian Chemistry Conference, Calimanesti-Caciulata, Romania, 2016, p. 11.
  9. Șmigon C., Lungu L., Aricu A., Ciocarlan A., Barba A., Vornicu N. Synthesis of new biological active tetranorlabdane compounds with thiadiazole units. In: The XXXIV-th Romanian Chemistry Conference, Calimanesti-Caciulata, Romania, 2016, p. 14.
  10. Lungu L., Smigon C., Aricu A., Ciocarlan A., Barba A., Moldoveanu C. Synthesis of new tetranorlabdane compounds with oxadiazole units. In: A. I. Cuza University Days, Faculty of  Chemistry Conference, 2016, p. 63.
  11. Aricu A.,  Lungu L.,  Ciocarlan A., Barba A., Dragancea D. synthesis of  new biologically active polyfunctional terpenoids based on industrial wastes. In: The 6th International Conference Ecological & Environmental Chemistry. Chisinau, R. Moldova, 2017, p.168.
  12. Șmigon C., Lungu L., Aricu A., Vornicu N. Microwave assisted of some new tetranorlabdane compounds and their biological activity. In: The 6th International Conference Ecological & Environmental Chemistry. Chisinau, R. Moldova, 2017, p. 221. 
  13. Lungu L., Aricu A., Blaja S., Ciocarlan A., Barba A. Synthesis of new potential biologically active tetra- and pentanorlabdane compounds with 1,3-thiazole units. In: 20th Romanian International Conference on Chemistry and Chemical Engineering, Poiana-Brasov, Romania, 2017, p. S2- 52.
  14. Aricu A., Kuchkova K., Secara E., Barba A., Dragalin I., Vlad P., Ungur N. Synthesis of iso-drimenoic acid amides with diazine units from norambreinolide In: 20th Romanian International Conference on Chemistry and Chemical Engineering, Poiana-Brasov, Romania, 2017, p. S2-84.
  15. Aricu A., Cucicova C., Lungu L., Ciocarlan A., Secara E. Synthesis and applications of new nitrogen-containing drimane and homodrimane compounds. In: 20th Romanian International Conference on Chemistry and Chemical Engineering, Poiana-Brasov, Romania, 2017, p. S2-202.
  16. Aricu A., Lungu L., CiocarlanA., Barba A., Vornicu N., Mangalagiu I. Synthesis, structure and antimicrobial activity of new homodrimane sesquiterpenoids with oxa- and thiadiazole units. In: The XXXV-th Romanian Chemistry Conference, Calimanesti-Caciulata, Romania, 2018, p. 13.
  17. Lungu L., Tenu N., Aricu A., Barba A., Ciocarlan A., Vornicu N. Synthesis of new biological active tetranorlabdane compounds with 1,3,4-thiadiazole units. In: The XXXV-th Romanian Chemistry Conference, Calimanesti-Caciulata, Romania, 2018, p. 16.
  18. Blaja S., Lungu L., Aricu A., Ciocarlan A. Synthesis of new potential active trinorlabdane compounds with 1,3-thiazole units. In: The XXXV-th Romanian Chemistry Conference, Calimanesti-Caciulata, Romania, 2018, p. 6.
  19. Ciocarlan A., Lungu L., Aricu A., Vornicu N. Antifungal and antibacterial acivities of some new homodrimane sesquiterpenoids bearing 1,3,4-oxadiazole units. In: The XXXV-th Romanian Chemistry Conference, Calimanesti-Caciulata, Romania, 2018, p. 30.
  20. Aricu A.N., Kuchkova K.I., Secara E.S., Barba A.N., Dragalin I.P., Ungur N.D. Synthesis of some new homodrimane sesquiterpenoids with 1,3,4-oxadiazole fragment. In: The XXXV-th Romanian Chemistry Conference, Calimanesti-Caciulata, Romania, 2018, p. 35.
  21. Nina Ciocarlan, Alexandru Ciocarlan, Ion Dragalin, Aculina Aricu, Inga Zinicovscaia, Svetlana Gundorina. GC–MS and neutron activation (NAA) analysis of medicinal Teucrium L. species. The 22nd National Conference with International Participation “New Cryogenic and Isotope Technologies for Energy and Environment”. EnergEn 2018. Baile-Govora, Romania, 24-26 October, 2018, p. 199.
  22.  Alexandru Ciocarlan, Aculina Aricu, Mariana Deleanu, Comparative spectroscopic and chromatographic quantification of nicotine in moldavian tobacco. The 22nd National Conference with International Participation “New Cryogenic and Isotope Technologies for Energy and Environment”. EnergEn 2018. Baile-Govora, Romania, 24-26 October, 2018,  p. 217.
  23. Blaja, Svetlana; Lungu, Lidia; Ciocarlan, Alexandru; Shova, Sergiu; Aricu, Aculina. Synthesis and characterization of new copper(II) complex with drimane thiosemicarbazone ligands. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 209. ISBN 978-9975-62-428-2.
  24.  Lungu, Lidia; Blaja, Svetlana; Ciocarlan, Alexandru; Ilker, Ozer; Aricu, Aculina; Vornicu, Nicoleta. Synthesis of new active nitrogen and sulfur containing norlabdanic compounds. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 226. ISBN 978-9975-62-428-2.
  25. Lungu, Lidia; Ciocarlan, Alexandru; Aricu, Aculina; Ilker, Ozer; Barbă, Alic. Synthesis of new potential active homodrimane sesquiterpenoids with 1,3,4-thiadiazole units. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 225. ISBN 978-9975-62-428-2.
  26. Aricu, Aculina; Secara, Elena; Kuchkova, Kaleria; Barbă, Alic; Dragalin, Ion; Ungur, Nicon. Synthesis of some new drimane compounds with 1,3,4-oxadiazole fragment. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 238. ISBN 978-9975-62-428-2.
  27. Aricu, Aculina; Kuchkova, Kaleria; Secara, Elena; Barbă, Alic; Dragalin, Ion; Ungur, Nicon. Synthesis of some new homodrimane sesquiterpenoids with 1,3,4-oxadiazole fragment. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 239. ISBN 978-9975-62-428-2.
  28. ARICU, Aculina. The institute of chemistry at 60 years’ anniversary. Brief history, achievements and perspectives. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 8. ISBN 978-9975-62-428-2.
  29.  Lungu, Lidia; Ciocarlan, Alexandru; Aricu, Aculina; Bîrca, Natalia. The use of some non-conventional methods in chemistry of bicyclohomofarnesenic methyl esters. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 53. ISBN 978-9975-62-428-2.
     

Patents

  1. Patent 4326 MD, N-(D8,13-Biciclohomofarnesenoilamino)-carbazolul şi procedeu de cultivare a cianobacteriei Nostoc Linckia, cu utilizarea acestuia. Cucicova, C., Rudic, V., Arîcu, A.,  Cepoi, L., Rudi, L., Secara, E., Valuţa, A., Barbă, A., Miscu, V., Vlad, P., Chiriac, T. BOPI 2/2015, p. 27.
  2. Patent 4327 MD,  N-(D8,13-Biciclohomofarnesenoil)-3-amino-1,2,4-triazolul şi procedeu de cultivare a cianobacteriei Nostoc Linckia, cu  utilizarea acestuia. Cucicova, C., Rudic, V., Arîcu, A.,  Cepoi, L., Rudi, L., Secara, E., Valuţa, A., Barbă, A., Miscu, V., Vlad, P., Chiriac, T. BOPI 2/2015, p. 27-28.
  3. Patent  4370B1 „11,12-Bis-p-tolyl-piridazonil-drim-5(6),8(9)-diene-7-one with Antifungal and Antibacterial Properties”,  Aricu A.; Mangalagiu I.; Ciocarlan A.; Lungu L.; Zbancioc Gh.; Vornicu N., BOPI. 9/2015.
  4. Patent 4573 MD, Compusul 13-amino-14,15-dinorlabd-8(9)-enă pentru utilizare în calitate de remediu antimicotic. Arîcu Aculina, Kuchkova Kaleria, Secara Elena, Barba Alic, Dragalin Ion, Ungur Nicon, BOPI 6/2018.
  5. patent 4580 C1, 28.02.2019, MD, Compus (1R,2R,8aS)-1-((5-mercapto-1,3,4-thiadiazol-2-il)metil)-2,5,5,8atetrametildecahidro nafthalen-2-ol cu proprietăţi antifungice şi antibacteriene. Arîcu Aculina, Lungu Lidia, Ciocarlan Alexandru, Vornicu Nicoleta, BOPI 1/2019.
  6. Patent 4630 C1, MD, , Compusul 1-(4-((4aS,8aS)-2,5,5,8a-tetrametil-3,4,4a,5,6,7,8,8a-octahidronaftalen1-il)butan-2-il)guanidină cu activitate antiproliferativă şi citotoxică. Arîcu Aculina, Kuchkova Kaleria, Duca Gheorghe, Secara Elena, Barba Alic, Dragalin Ion, Ungur Nicon,  BOPI 5/2019.
  7. Patent 4631 C1, MD, Compusul N-carbamimidoil-2-((8aS)-2,5,5, 8a-tetrametil-3,4,4a,5,6,7,8,8aoctahidronaftalen-1-il)acetamidă cu activitate antiproliferativă şi citotoxică. Arîcu Aculina, Kuchkova Kaleria, Duca Gheorghe, Secara Elena, Barba Alic, Dragalin Ion, Ungur Nicon, BOPI 5/2019.
  8. Patent MD 4765. 5-(Homodrim-6,8- dien-11-il)-1,3,4-tiadiazol-2(3H)-imină cu proprietăţi antifungice. Arîcu, A., Ciocârlan, A., Lungu, L., Blaja, S., Vornicu, N. BOPI 2/2021.
  9. Patent MD 4780/2021. (Z/E)-2-(1- ((1R,2R,8aS)-2-hidroxi-2,5,5,8a-tetrametildecahidronaftalen-1-il)propan-2- iliden)hidrazincarbotioamidă pentru utilizare în calitate de remediu antifungic. Arîcu, A., Ciocârlan, A., Lungu, L., Blaja, S., Vornicu, N. BOPI 5/2021.

National projects

  1. Chemical study of secondary metabolites from local natural sources and valorization of their application potential basing on broadening molecular diversity with multiple functionality (code 010601)
    Period: 2024-2027
    Subprogram manager: Dr. habilitate, assoc. prof. Veaceslav KULCITKI
  2. ANCD/20.80009.8007.03. New products with preventive and therapeutic potential basing on natural products of vegetal origin and modern methods of organic synthesis
    Period: 2020-2023
    Project manager: dr. habilitat Veaceslav KULCIȚKI 
  3. CSSDT/15.817.02.14A. Elaboration of methods for obtaining valuable terpenoids by valorization of renewable resources from Republic of Moldova
    Period: 2015-2019
    Project manager: dr. habilitate, assoc. prof. Nicon UNGUR
  4. CSȘDT/16.00353.50.04A. Design, directed synthesis and study of antibacterial and antitumor activity of chiral terpenic compounds and their coordinative combinations with transition metals
    Period: 2016-2017
    Project manager: dr. habilitate, assoc. prof. Aculina ARICU
     

Internațional projects

  1. AȘM-STCU/18.80013.5007.01/6330STCU. Synthesis of biologically active norlabdanic compounds with heterocyclic structural units based on agricultural waste.
    Period: 2018-2019;
    Project manager: Dr. habilitate, assoc. prof. Aculina ARICU
  2. INTERREG/Danube Hazard M3C. Tackling hazardous substances pollution in the Danube River Basin by Measuring, Modelling-based Management and Capacity building (Danube Hazard M3C)
    Period: 2020-2022
    Project manager: dr. Oleg BOGDEVICI
  3. COST/CA18202. Network for equilibria and chemical thermodynamics advanced research (NECTAR) 
    Period: 2019-2023
    Project manager: dr. habilitat Igor POVAR
  4. AȘM-ANCSI/16.80013.16.02.06/Ro. Directed synthesis and study of chiral complexes containing terpeno-heterocyclic ligands.
    Period: 2016-2017;
    Project manager: Dr. habilitate, assoc. prof. Aculina ARICU