Chemical study of secondary metabolites from local natural sources and valorization of their application potential basing on broadening molecular diversity with multiple functionality (MetNatVal))

Secondary metabolites produced by living organisms provide important adaptive and survival functions in terrestrial and aquatic ecosystems. Throughout evolution, plants and animals have developed protection mechanisms against invasive species by means of secondary metabolites which are, as a rule, chemical compounds with low or medium molecular weight that exhibit relevant biological activity. Thus, the study of natural secondary metabolites offers an excellent perspective to identify new substances with interesting properties, which can be exploited in different application fields.

The main aim of the current research project proposed to be carried out in the period 2024-2027 is focused on the identification of secondary metabolites from local plant sources, available both from agriculture and spontaneous flora, and the development based on them of new substances and technological solutions with a wide impact in the most important strategic fields of scientific and economic development of the Republic of Moldova, including health protection, agriculture and plant protection, food industry, as well as in specific branches related to products with high added value such as perfumery and cosmetics. The project concept assumes a holistic approach that covers all relevant aspects for the efficient exploration of plant material from available sources, including: analytical study by modern physico-chemical methods, preparative isolation, structural modification via organic synthesis, advanced study of properties related to biological activity and evaluating the potential for commercial exploitation. The realization of the project will involve two scientific laboratories with complementary skills in the field of chemistry of natural compounds and organic synthesis and an impressive human potential, including 4 habilitate and 14 doctors in chemistry. More than 40% of the project's research team is represented by researchers under the age of 40, and two participants in the project are members of AȘM. The planned activities will include research topics for bachelor's, master's and doctoral theses, which will be carried out by students of the Faculty of Chemistry and Chemical Technology.