Kulcitki Veaceslav

Title/degree Doctor habilitate, assoc. prof.
Position Head of the Laboratory Chemistry of Natural and Biologically Active Compounds
Office 309
Phone/fax (+373 22) 73 97 75
Email [email protected]
[email protected]
[email protected]
Professional links

Scopus ID: 6506927017
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Research areas

Synthetic organic chemistry, chemistry of natural compounds, medicinal chemistry, analytical chemistry. Major contributions in the field of terpenoid chemistry, in particular:

  • Synthesis of diverse families of terpenic compounds according to the Random Biomimetic Principle;
  • Application of cationic rearrangements for skeletalmodifications of terpenoids;
  • Application of free radical transformations for the functionalization of terpenoids with heteroatoms;
  • SAR studies in the terpenoid series aimed to the identification of biologically active derivatives;
  • The use of HPLC, NMR and GC-MS methods for the analysis of secondary metabolites in vegetal sources;
  • Valorizing vegetal materials for the isolation of valuable secondary metabolites;

Implementation of Green Chemistry principles in the practical valorizing of natural products.

Relevant publications
Projects

Manuals, chapters in monographs

  1. Arîcu, A., Kulcițki, V., Ungur, N. Sclareolul - Materie Primă Sustenabilă Pentru Sinteza Compușilor Terpenici cu Valoare Adăugată Înaltă. În: Chimie Ecologică: Istorie și Realizări. Academicianul Gheorghe Duca, 70 Ani de la Naștere. Chișinău, 2022, pp. 86-114. ISBN 978-9975-159-05-0.
  2. Kulcițki, V. Strategia Sintezei Organice. Principii Generale și Noțiuni Fundamentale. Suport de curs. USDC, Chișinău, 2020. ISBN 978-9975-89-164-6. 94 p.
  3. Kulcițki, V. Istoria și Evoluția Cercetării în Chimie. Suport de curs. USDC, Chișinău, 2019. ISBN 978-9975-108-98-0. 114 p.

Articles

  1. Morarescu, O.; Grinco, M.; Kulciţki, V.; Barba, A.; Garbuz, O.; Gulea, A. and Ungur, N. Synthesis of Highly Functionalized Biologically Active Tetracyclic Diterpenoids from ent-Kaur-16-en-19-oic Acid under Modified Prévost-Woodward Reaction Conditions. Russ. J. Org. Chem., 2021,  57, 1931–1939. DOI: 10.1134/S1070428021120058.
  2. Morarescu, O., Grinco, M., Kulciţki, V., Shova, S., Ungur, N. An Alternative Approach towards C-12 Functionalized Scalaranic Sesterterpenoids. Synthesis of 17-Oxo-20-norscalaran-12α,19-O-lactone. Marine Drugs, 2021, 19(11), 636. DOI: 10.3390/md19110636.
  3. Pruteanu, E., Gîrbu, V., Ungur, N., Persoons, L., Daelemans, D., Renaud, P. and Kulcițki, V. Preparation of Antiproliferative Terpene-Alkaloid Hybrids by Free Radical-Mediated Modification of ent-Kauranic Derivatives. Molecules, 2021, 26(15), pp. 4549-4568. DOI: 10.3390/molecules26154549.
  4. Organ, A.; Gîrbu, V.; Cojocaru-Toma, M.; Kulciţki, V.; Cotelea T.; Ungur, N. Therapeutic potential and preventive effects of major triterpenic secondary metabolites from Lavandula angustifolia. Revista Farmaceutică a Moldovei, 2021, 45(1), 79-81.
  5. Morarescu, O., Traistari, M., Barba, A., Duca, G., Ungur, N. and Kulcițki, V. One-step selective synthesis of 13-epi-manoyl oxide. Chem.J.Mold., 2021, 16 (1), pp. 99-104. DOI: http://dx.doi.org/10.19261/cjm.2021.820.
  6. Pruteanu, E.; Tappin, N.D.; Gîrbu, V.; Morarescu, O.; Dénès, F.; Kulciţki, V. and Renaud, P. Forskolin Editing via Radical Iodo-and Hydroalkylation. Synthesis, 2021, 53(07), pp. 1247-1261.  DOI: 10.1055/s-0040-1706003.
  7. Morarescu, O.; Grinco, M.; Kulciţki, V.; Barba, A.; Garbuz, O.; Gudumac, V.; Gulea, A. and Ungur, N. A Straightforward Synthesis of Natural Oxygenated ent-Kaurenoic Acid Derivatives. Synthetic Communications, 2021, 51(1), pp. 123-133. DOI: 10.1080/00397911.2020.1821225.
  8. Sîrbu, T.; Girbu, V.; Harghel, P.; Rusu, V.; Ungur, N. and Kulciţki, V. Selectivity Control in Terpene Rearrangements: A Biomimetic Synthesis of the Halimanic Bicyclic Core. Synthesis, 2019, 51(09), pp. 1995-2000. DOI: 10.1055/s-0037-1610686.

Patents

  1. Kulciţki, V., Girbu, V., Pruteanu, E., Renaud, Ph., Daelemans, D., Ungur, N. New Spiro-g-Lactams, ent-Kaurenoic Acid Derivatives, with Selective Cytotoxic Activity. Patent of Republic of Moldova. Nr  4786 (13) B1, BOPI, 2022, (1), pp. 49.
  2. Kulciţki, V., Girbu, V., Pruteanu, E., Renaud, Ph., Daelemans, D., Ungur, N. Methyl ent-15-hydroxy-16-azido-17-carboxymethoxymethylkauranoate with Selective Cytotoxic Activity. Patent of Republic of Moldova. Nr  4785 (13) B1, BOPI, 2022, (1), pp. 47-48.
  3. Kulciţki, V., Girbu, V., Pruteanu, E., Renaud, Ph., Daelemans, D., Ungur, N. (16R)-Spiro[pyrrolidine-2´,16-ent-17-norkauran]-19-oic Acid Methyl Ester with Selective Cytotoxic Activity. Patent of Republic of Moldova. Nr  4792 (13) B1, BOPI, 2022, (2), pp. 57-58.
  4. Kulciţki, V.; Gîrbu, V.; Pruteanu, E.; Renaud, P.; Daelemas, D.; Mollo, E.; Defranoux, F.; Ungur, N. Methyl ent-17-amino-kauran-19-oate with Selective Cytotoxic Activity. Patent of Republic of Moldova. Nr  4718 (13) B1, BOPI, 2020, (10), pp. 47-48.
  5. Robu, Ș.; Prisacari, V.; Kulcițki, V.; Grinco, M.; Barba, A. Polymeric Material with Antibacterial Properties Based on Lignin Grafted with N'-(5-nitrofurfurylidene) isonicotinehydrazide. Patent of Republic of Moldova. Nr 4506, BOPI, 2017, (8), p. 29.

Abstracts

  1. Cojocaru-Toma, M.; Cotelea, T.; Organ, A.; Jian M.; Cobzac V.; Nacu V.; Cirimpei O.; Ungur, N.; Kulcițki, V. Evaluarea in vitro a Potențialului Regenerativ al Extractelor din Lavandula Angustifolia Mill. Conferinţa Ştiinţifico-practică Națională cu participare Internațională „Actualități și perspective în studiul farmaceutic al plantelor medicinale”. Chișinău, 01 Octombrie 2021. P. 40.
  2. Gîrbu, V.; Grinco, M.; Barbă, A.; Duca, Gh.; Ungur, N.; Kulcițki, V. Utilizarea Spectroscopiei RMN pentru Evaluarea Analitică a Extractelor de Levănțică. Conferinţa Ştiinţifico-practică Națională cu participare Internațională „Actualități și perspective în studiul farmaceutic al plantelor medicinale”. Chișinău, 01 Octombrie 2021. P. 83.
  3. Organ, A.; Gîrbu, V.; Cotelea, T.; Cojocaru-Toma, M.; Ungur, N.; Kulcițki, V. Extracția și Fracționarea Rapidă a Deșeurilor de Levănțică. Conferinţa Ştiinţifico-practică Națională cu participare Internațională „Actualități și perspective în studiul farmaceutic al plantelor medicinale”. Chișinău, 01 Octombrie 2021. P. 87.
  4. Ungur, N. and Kulciţki, V. Mollecular Rearrangements in the Synthesis of Bioactive Terpenoids with New Carbon Skeletons. In: New frontiers in natural product chemistry, Chișinău, 2021, p. 18. Available online. DOI: 10.19261/nfnpc.2021.ab10.
  5. Gîrbu, V., Pruteanu, E., Ungur, N., Persoons, L., Daelemans, D., Renaud, P. and Kulciţki, V. New Cytotoxic ent-Kauranes with Unprecedented Pharmacophores. In: New frontiers in natural product chemistry, Chișinău, 2021, p. 26. Available online. DOI: 10.19261/nfnpc.2021.ab19.
  6. Grinco, M., Barba, A., Duca, G., Ungur, N. and Kulciţki, V. The Use of qNMR Spectroscopy for Analytical Evaluation of Natural Extracts. The Case of Apple Pomace. In: New frontiers in natural product chemistry, Chișinău, 2021, p. 29. Available online. DOI: 10.19261/nfnpc.2021.ab22.
  7. Cojocaru-Toma, M., Cotelea, T., Kulciţki, V., Ungur, N., Cirimpei, O., Nacu, V., Jian, M., Cobzac, V. and Organ, A. Phytochemical Study and Antioxidant Action of Lavandulae Angustifoliae Residues. In: New frontiers in natural product chemistry, Chișinău, 2021, p. 17. Available online. DOI: 10.19261/nfnpc.2021.ab11.
  8. Jian, M., Cobzac, V., Gîrbu, V., Morărescu, C.O., Organ, A., Cojocaru-Toma, M., Cotelea, T., Cirimpei, O., Kulciţki, V. and Nacu, V. In vitro Evaluation of Lavandula Augustifolia and Hippophae rhamnoides Extracts on Promotion of Bone Marrow Mesenchymal Stem Cells Proliferation. In: New frontiers in natural product chemistry, Chișinău, 2021, p. 31. Available online. DOI: 10.19261/nfnpc.2021.ab24.
  9. Grinco, M., Barba, A. and Kulciţki, V. Extraction Of Pharmaceutical Grade Lignins and their Ozonolytic Cleavage in a Deep Eutectic Solvent. In: New frontiers in natural product chemistry, Chișinău, 2021, p. 28. Available online. DOI: 10.19261/nfnpc.2021.ab21.
  10. Gîrbu, V., Ungur, N., Renaud, P. and Kulciţki, V. Free Radical Functionalizations of Labdanes and Related Diterpenoids. In: New frontiers in natural product chemistry, Chișinău, 2021, p. 27. Available online. DOI: 10.19261/nfnpc.2021.ab20.
  11. Morărescu, C.O., Traistari, M., Barba, A., Duca, G., Ungur, N. and Kulciţki, V. Selective Synthesis of 13-epi-Manoyl Oxide. In: New frontiers in natural product chemistry, Chișinău, 2021, p. 34. Available online. DOI: 10.19261/nfnpc.2021.ab27.
  12. Kulciţki, V., Cazacu, C., Morărescu, C.O., Pruteanu, E., Gîrbu, V., Ungur, N. and Renaud, P. Late Stage Functionalization of Unactivated C-H Bonds in Terpenes–A Fruitful Field for Free Radical Chemistry. In: New frontiers in natural product chemistry, Chișinău, 2021, p. 20. Available online. DOI: 10.19261/nfnpc.2021.ab13.
  13. Morărescu, C.O., Grinco, M., Kulciţki, V. and Ungur, N., 2021. A Short and Efficient Synthesis of a C(12) - Functionalized Norscalarane. 21st Tetrahedron Symposium, 21-24 June. Online: live and on demand. P2.40. Available online: https://app.oxfordabstracts.com/events/1644/program-app/titles.
  14. Grinco, M.; Gîrbu, V.; Pruteanu, E.; Morarescu, O.; Kulciţki, V.; Ungur, N. Synthesis of Some Guanidine Diterpenoids. The International Conference “Achievements and Perspectives of Modern Chemistry” dedicated to the 60th anniversary from the foundation of the Institute of Chemistry, Chişinău, Moldova, October 9 – 11, 2019, p. 222.
  15. Morarescu, O.; Grinco, M.; Kulciţki, V.; Ungur, N. Synthesis of a C12-Functionalized Norscalarane from Sclareol. The International Conference “Achievements and Perspectives of Modern Chemistry” dedicated to the 60th anniversary from the foundation of the Institute of Chemistry, Chişinău, Moldova, October 9 – 11, 2019, p. 230.
  16. Morarescu, O.; Grinco, M.; Kulciţki, V.; Garbuz, O.; Gudumac, V.; Gulea, A.; Ungur, N. Synthesis of Halogenated Derivatives of       ent-Kaur-16-en-19-oic Acid. The International Conference “Achievements and Perspectives of Modern Chemistry” dedicated to the 60th anniversary from the foundation of the Institute of Chemistry, Chişinău, Moldova, October 9 – 11, 2019, p. 246.
  17. Гырбу, В. М.; Кульчицкий, В. Н.; Унгур, N. Д., Рено, Ф. Функционализация Дитерпеноидов Посредством Радикальных Реакций. In: „Современные достижения органической химии”, Школа молодых химиков государств-участников СНГ, 2-8 декабря 2019, Душанбе, Республика Таджикистан, p. 15.
  18. Морареску, O.; Гринько, M.; Кульчицкий, В.; Унгур, N. Химическая Модификация энт-Каур-16-ен-19-овой и энт-трахилобан-19-овой Кислот. In: „Современные достижения органической химии”, Школа молодых химиков государств-участников СНГ, 2-8 декабря 2019, Душанбе, Республика Таджикистан, p. 16.
  19. Morărescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Unusual Remote C-H Functionalization of Manoyl Oxides. IUPAC International Symposium on Biiorganic Chemistry – ISBOC-11, 27-29 september 2017, Konstanz, Germany. Abstracts of communication, p. 145.
  20. Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Expanding Structural Diversity of ent-kaurane Diterpenoids by Free Radical Chemistry. IUPAC International Symposium on Biiorganic Chemistry – ISBOC-11, 27-29 september 2017, Konstanz, Germany. Abstracts of communication, p. 149.
  21. Kulciţki, V.; Sîrbu, T.; Gîrbu, V.;  Ungur, N.; Rusu, V. A Biomimetic Synthesis of Halimanic Bicyclic Core. IUPAC International Symposium on Bioorganic Chemistry – ISBOC-11, 27-29 september 2017, Konstanz, Germany. Abstracts of communication, p. 136.
  22. Morărescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Unusual Remote C-H Functionalization of Manoyl Oxides by “Travelling” Radical. 2017 Villars Summer School “Trends in Organic Synthesis”. August 27-31, 2017 Villars-sur-Ollon, Switzerland. Abstracts of communication, p-14.
  23. Morărescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Structural Modification of ent-Kaurane Diterpenoids by Atom Transfer Radical Additions. 2017 Villars Summer School “Trends in Organic Synthesis”. August 27-31, 2017 Villars-sur-Ollon, Switzerland. Abstracts of communication, p-28.
  24. Gîrbu, V.; Pruteanu, E.; Ungur, N.; Barbă, A.; Kulciţki, V. Terpene Ozonolysis in Green Solvents. The 6th International Conference Ecological & Environmental Chemistry-2017, March 2-3, 2017, Chisinau, Republic of Moldova. Abstracts of communication, p. 229.
  25. Grinco, M.; Barbă, A.; Ungur, N.; Kulciţki, V. Lignin Ozonolysis in Deep Eutectic Solvents. The 6th International Conference Ecological & Environmental Chemistry-2017, March 2-3, 2017, Chisinau, Republic of Moldova. Abstracts of communication, pp. 187-188.
  26. Kulciţki, V. Ozonolysis of Alkenes: Transformations Far Beyond C=C Cleavage. The 6th International Conference Ecological & Environmental Chemistry-2017, March 2-3, 2017, Chisinau, Republic of Moldova. Abstracts of communication, pp. 190-191.

National projects

  1. Chemical study of secondary metabolites from local natural sources and valorization of their application potential basing on broadening molecular diversity with multiple functionality (code 010601)
    Period: 2024-2027
    Subprogram manager: Dr. habilitate, assoc. prof. Veaceslav KULCITKI
     
  2. ANCD/20.80009.8007.03. New products with preventive and therapeutic potential basing on natural products of vegetal origin and modern methods of organic synthesis
    Period: 2020-2023
    Project manager: dr. habilitat Veaceslav KULCIȚKI 
     
  3. CSSDT/15.817.02.14A. Elaboration of methods for obtaining valuable terpenoids by valorization of renewable resources from Republic of Moldova
    Period: 2015-2019
    Project manager: dr. habilitate, assoc. prof. Nicon UNGUR
     

International projects:

  1. AȘM-CNCI/15.820.16.02.02/it. Synthesis of guanidine terpenoids with relevant biological activity and therapeutic potential.
    Period: 2015-2016;
    Project manager: Dr. habilitate, assoc. prof. Nicon UNGUR

  2. AȘM-CNCI/18.80013.16.02.02/it. Synthesis of guanidine terpenoids with relevant biological activity and therapeutic potential.
    Period: 2018-2019;
    Project manager: Dr. habilitate, assoc. prof. Nicon UNGUR

  3. SCOPES/IZ73Z0-152346. Modification of natural compounds mediated by free radicals
    Period: 2015-2016
    Project manager: Dr. habilitate, assoc. prof.  Veaceslav KULCITKI

  4. AȘM-STCU/15.820.18.03.07/5984STCU. Unconventional green processes for processing renewable raw materials.
    Period: 2015-2017;
    Project manager: Dr. habilitate, assoc. prof. Veaceslav KULCITKI