Title/degree | Doctor |
Position | Scientific researcher |
Laboratory | Chemistry of Natural and Biologically Active Compounds |
Office | 318 |
Phone/fax | (+373 22) 73 97 69 |
[email protected], [email protected] |
|
Professional links |
Research areas
Bioorganic chemistry; chemistry of natural and physiologically active compounds,physico-chemical methods of analysis, chemical synthesis.
Relevant publications
Projects
Articles
- Kuchkova K., Aricu A., Secara E., Barba A., Vlad P., Macaev F., Melnic E., Kravtov V. Synthesis and structure of homodrimanic sesquiterpenoids containing 1,2,4-triazole and carbazolerings. Chem. Nat. Compd., 2015, vol. 51, Nr 4p. 684-688.
- Aricu A. N., Kuchkova K. I., Barba A. N., Dragalin I. P., Shova S. G., Vornicu N., Gorinchoi E. K., Sekara E. S., Lungu L. V., Niculaua M., Ungur N. D., Vlad P. F., Synthesis from norambreinolide, structure, and antimicrobial activity of dihomodrimane sesquiterpenoids with azine, hydrazide, and dihydrazide fragments. In: Chem. Nat. Comp., 2016, vol. 52, nr. 6, p. 1029-1036. DOI: https://doi.org/10.1007/s10600-016-1854-6 (I.F. 1.029).
- Aricu A. N., Kuchkova K. I., Sekara E. S., Barba A. N., Dragalin I. P., Ungur N. D., Melnic E., Kravtsov V.Kh. Synthesis and structure of drimane sesquiterpenoids containing diazine, 1,2,4-triazole and carbazole rings. In: Chem. Nat. Comp., 2018, vol. 54, nr. 3, p. 455-460. DOI: https://doi.org/10.1007/s10600-018-2378-z.
- Duca, Gheorghe; Aricu, Aculina; Kuchkova, Kaleria; Secara, Elena; Barbă, Alic; Dragalin, Ion; Ungur, Nicon; Spengler, Gabriella. Synthesis, structural elucidation and biological evaluations of new guanidine-containing terpenoids as anticancer agents. In: Natural Product Research. 2019, nr. 21(33), pp. 3052-3056. ISSN 1478-6419. DOI: https://doi.org/10.1080/14786419.2018.1516658.
- Aricu A.N., Kuchkova K.I., Secara-Cushnir E.S., Barba A.N., Ungur N.D. Synthesis and Antimicrobial Activity of New Drimane and Homodrimane Sesquiterpenoids with Oxadiazole and Thiadiazole Fragments. Chemistry of Natural Compounds 2020, 56(4), 656-662. DOI: https://doi.org/10.1007/s10600-020-03115-x ( I.F. 1.029).
Abstracts of scientific communications
- Rudic V., Arîcu A., Cucicova C., Cepoi L., Rudi L., Codreanu S., Secara E., Valuța A., Barbă A., Miscu V., Vlad P., Chiriac T. Using of new hybrid compounds with terpenoid and azaheterociclic skeleton to increase I antioxidant activity of the Nostoc Linckia. In: The XVIII-th Conference “Physical Methods in Coordination and Supramolecular Chemistry”, Chisinau, R. Moldova, 2015, p. 130.
- Aricu A.N., Kuchkova K.I., Barba A.N., Secara E.S., Dragalin I.P., Ungur N.D., Vlad P.F. Synthesis of 8,9-bicyclohomofarnesenic acid guanidine derivatives from norambreinolide. In: The XXXIV-th Romanian Chemistry Conference, Calimanesti-Caciulata, Romania, 2016, p. 9.
- Aricu A.N., Kuchkova K.I., Barba A.N., Secara E.S., Dragalin I.P., Ungur N.D., Vlad P.F. Synthesis of guanidine derivatives of 12-amino-11-dihomodrimane-8α-ol and 13-amino-14,15-dinorlabd-8(9)-ene. In: The XXXIV-th Romanian Chemistry Conference, Calimanesti-Caciulata, Romania, 2016, p. 22.
- Aricu A., Kuchkova K., Secara E., Barba A., Dragalin I., Vlad P., Ungur N. Synthesis of iso-drimenoic acid amides with diazine units from norambreinolide In: 20th Romanian International Conference on Chemistry and Chemical Engineering, Poiana-Brasov, Romania, 2017, p. S2-84.
- Aricu A., Cucicova C., Lungu L., Ciocarlan A., Secara E. Synthesis and applications of new nitrogen-containing drimane and homodrimane compounds. In: 20th Romanian International Conference on Chemistry and Chemical Engineering, Poiana-Brasov, Romania, 2017, p. S2-202.
- Aricu, Aculina; Secara, Elena; Kuchkova, Kaleria; Barbă, Alic; Dragalin, Ion; Ungur, Nicon. Synthesis of some new drimane compounds with 1,3,4-oxadiazole fragment. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 238. ISBN 978-9975-62-428-2.
- Aricu, Aculina; Kuchkova, Kaleria; Secara, Elena; Barbă, Alic; Dragalin, Ion; Ungur, Nicon. Synthesis of some new homodrimane sesquiterpenoids with 1,3,4-oxadiazole fragment. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 239. ISBN 978-9975-62-428-2.
Patents
- Patent 4326 MD, N-(D8,13-Biciclohomofarnesenoilamino)-carbazolul şi procedeu de cultivare a cianobacteriei Nostoc Linckia, cu utilizarea acestuia. Cucicova, C., Rudic, V., Arîcu, A., Cepoi, L., Rudi, L., Secara, E., Valuţa, A., Barbă, A., Miscu, V., Vlad, P., Chiriac, T. BOPI 2/2015, p. 27.
- Patent 4327 MD, N-(D8,13-Biciclohomofarnesenoil)-3-amino-1,2,4-triazolul şi procedeu de cultivare a cianobacteriei Nostoc Linckia, cu utilizarea acestuia. Cucicova, C., Rudic, V., Arîcu, A., Cepoi, L., Rudi, L., Secara, E., Valuţa, A., Barbă, A., Miscu, V., Vlad, P., Chiriac, T. BOPI 2/2015, p. 27-28.
- Patent 4573 MD, Compusul 13-amino-14,15-dinorlabd-8(9)-enă pentru utilizare în calitate de remediu antimicotic. Arîcu Aculina, Kuchkova Kaleria, Secara Elena, Barba Alic, Dragalin Ion, Ungur Nicon, BOPI 6/2018.
- Patent 4630 C1, MD, , Compusul 1-(4-((4aS,8aS)-2,5,5,8a-tetrametil-3,4,4a,5,6,7,8,8a-octahidronaftalen1-il)butan-2-il)guanidină cu activitate antiproliferativă şi citotoxică. Arîcu Aculina, Kuchkova Kaleria, Duca Gheorghe, Secara Elena, Barba Alic, Dragalin Ion, Ungur Nicon, BOPI 5/2019.
- Patent 4631 C1, MD, Compusul N-carbamimidoil-2-((8aS)-2,5,5, 8a-tetrametil-3,4,4a,5,6,7,8,8aoctahidronaftalen-1-il)acetamidă cu activitate antiproliferativă şi citotoxică. Arîcu Aculina, Kuchkova Kaleria, Duca Gheorghe, Secara Elena, Barba Alic, Dragalin Ion, Ungur Nicon, BOPI 5/2019.
National projects
- ANCD/20.80009.8007.03. New products with preventive and therapeutic potential basing on natural products of vegetal origin and modern methods of organic synthesis
Period: 2020-2023
Project manager: dr. habilitat Veaceslav KULCIȚKI - CSSDT/15.817.02.14A. Elaboration of methods for obtaining valuable terpenoids by valorization of renewable resources from Republic of Moldova
Period: 2015-2019
Project manager: dr. habilitate, assoc. prof. Nicon UNGUR - CSȘDT/16.00353.50.04A. Design, directed synthesis and study of antibacterial and antitumor activity of chiral terpenic compounds and their coordinative combinations with transition metals
Period: 2016-2017
Project manager: dr. habilitate, assoc. prof. Aculina ARICU