Ungur Nicon

Titlul: Membru corespondent, doctor habilitat, conferențiar cercetător
Funcția: Cercetător ştiinţific principal
Laborator: Chimia Compușilor Naturali și Biologic Activi
Birou:  301
Telefon/fax: (+373 22) 73 97 75
Email: [email protected]
Profil/cont personal:

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Domeniul de cercetare

Chimie bioorganică, chimie organică sintetică, chimia compuşilor naturali, isoprenoide. Contribuţii majore în chimia organică, în particular:

  • elaborarea metodelor biomimetice de sinteză a mono-, sesqui-, di-şi sesterterpenoidelor ciclice din precursori alifatici şi/sau parţial ciclizaţi;
  • sinteza terpenoidelor naturale inclusiv cu activitate biologică;
  • sinteza unor terpenoide cu schelet nou prin regrupări moleculare;
  • sinteza terpenoidelor cu proprietăți odorante;
  • valorificarea resurselor locale de compuşi biologic activi.
Publicații relevante
Proiecte

Capitole din monografii internaţionale:

  1. Aricu, A.; Ungur, N.; Duca, Gh. Design, targeted synthesis and study of biological activity of some polifunctional chiral terpenic compounds. In: Compounds and materials for drug development and biomedical applications, Resp. ed. Gh G. Duca, F. Z. Macaev, Editura Academiei Române; EdituraIstros a Muzeului Brăilei „Carol I”, 2018, pp. 101-126. ISBN 978-973-27-2944-1.
  2. Ungur, N.; Arîcu, A.; Grinco, M. Occurrence, Biological Activity and Synthesis of Diterpenoid Amides. In: Diterpenoids. Types, Functions and Research. Brandon Jones Ed., Nova Science Publishers, Inc., New York, 2017, pp. 1-38. ISBN 9781536106718.


Articole:

  1. Morarescu, O.; Grinco, M.; Kulciţki, V.; Barba, A.; Garbuz, O.; Gudumac, V.; Gulea, A.; Ungur, N. A straightforward synthesis of natural oxygenated ent-kaurenoic acid derivatives. Synth. Commun.2020, 50, (reg. LSYC-2020-14375) (accepted). (IF 1.796)
  2. Sîrbu, T.; Girbu, V.;  Harghel, P.; Rusu, V.; Ungur, N.; Kulciţki, V. Selectivity Control in Terpene Rearrangements: A Biomimetic Synthesis of the Halimanic Bicyclic Core. Synthesis, 2019, 51 (9), 1995-2000. (IF 2.867)
  3. Duca, Gh.; Aricu, A.; Kuchkova, K.; Secara, E.; Barba, A.; Dragalin, I.; Ungur, N.; Spengler, G. Synthesis and anticancer activity of new guanidine - containing diterpenoids. Nat. Prod. Res., 2019, 33 (21), 3052-3056. (IF1.928)
  4. Carbone, M.; Ciavatta, M. L.; Mathieu, V.; Ingels, A.; Kiss, R.; Pascale, P.; Mollo, E.; Ungur, N.; Guo, Y.-W.; Gavagnin, M. Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues. J. Nat. Prod., 2017, 80 (5), 1339-1346. (IF 3.885).
  5. Grinco, M.; Gîrbu, V.; Gorincioi, E.; Barba, A.; Kulciţki, V.; Ungur, N. The first biomimetic synthesis of a diterpenoid with the ent-verrucosin A/B skeleton. Tetrahedron Lett., 2016, 57 (19), 2084-2086. (IF 2.347)
  6. Aricu, A. N.; Kuchkova, K. I.; Secara-Cushnir, E. S.; Barba, A. N.; Ungur, N. D.; Vornicu, N. Synthesis and Antimicrobial Activity of New Drimane and HomodrimaneSesquiterpenoids with Oxadiazole and Thiadiazole Fragments. Chem. Nat. Comp., 2020, 56 (4), 656–662. (IF 0.509)
  7. Aricu, A. N.; Kuchkova, K. I.; Secara, E. S.; Barba, A. N.; Dragalin, I. P.; Ungur, N. D.; Melnik, E.; Kravtsov, V. Kh. Synthesis and Structure of Drimane Sesquiterpenoids Containing Pyrimidine, Pyrazine, 1,2,4-triazole, and Carbazole Rings. Chem. Nat. Comp., 2018, 54 (3), 455-460. (IF 0.509)
  8. Aricu, A. N.; Kuchkova, K. I.; Barba, A. N.; Dragalin, I. P.; Shova, S. G.; Vornicu, N.; Gorinchoi, E. K.; Sekara, E. S.; Lungu, L.; Niculaua, M.; Ungur, N.; Vlad, P. F. Synthesis from norambreinolide, structure, and antimicrobial activity of dihomodrimanesesquiterpenoids with azine, hydrazide, and dihydrazide fragments. Chem. Nat. Comp., 2016, 52 (6), 1029-1036.
  9. Arîcu, A.; Ungur, N. Compuşi terpenici biologic activi de origine naturală şi sintetică. Akademos, 2015, (1), 81-86.
  10. Ungur, N.; Grinco, M.; Aricu, A.; Kuchkova, K. Isolation and synthesis of biologically active diterpenoids with the amide group. Pharm. Bull., 2015, (1-2), 58-72.
  11. Унгур, Н.; Арыку, А. Синтетические трансформации (-)-склареола и энт-каур-16-ен-19-овойкислоты в биоактивные терпеноиды. Фармацевтический Бюллетень, 2016, №3-4, 60-63.  
  12. Унгур, Н.; Гринько, М.; Арыку, А.; Кучкова, К. Выделение и синтез биологически активных дитерпеноидов с амидной группой. Фармацевтический Бюллетень, 2015, № 1-2, 58-71.
     

Brevete de invenţii:

  1. Arîcu, A.; Kuchkova, K.; Secara, E.; Barba, A.; Dragalin, I.; Ungur, N. Compusul 13-amino-14,15-dinorlabd-8(9)-enă pentru utilizare în calitate de remediu antimicotic. Brevet de Invenţie, Nr. 4573, MD, BOPI 6/2018.
  2. Arîcu, A.; Kuchkova, K.; Duca, Gh.; Secara, E.; Barba, A.; Dragalin, I.; Ungur, N. Compusul 1-(4-((4aS,8aS)-2,5,5,8a-tetrametil-3,4,4a,5,6,7,8,8a-octahidronaftalen1-il)butan-2-il)guanidină cu activitate antiproliferativă şi citotoxică. Brevet de invenţie, Nr. 4630, MD, BOPI 5/2019, p.41.
  3. Arîcu, A.; Kuchkova, K.; Duca, Gh.; Secara, E.; Barba, A.; Dragalin, I.; Ungur, N. Compusul N-carbamimidoil-2-((8aS)-2,5,5, 8a-tetrametil-3,4,4a,5,6,7,8,8aoctahidronaftalen-1-il)acetamidă cu activitate antiproliferativă şi citotoxică. Brevet de invenţie, Nr. 4631, MD, BOPI 5/2019, p.41-42.
  4. Kulciţki, V.; Gîrbu, V.; Pruteanu, E.; Renaud, Ph.; Daelemans, D.; Mollo, E.; Defranoux, F.; Ungur, N. Methyl ent-17-amino-kauran-19-oate with selective cytotoxic activity. Decizie de acordare a brevetului de inventieprinHotărârea AGEPI nr. 9579 din 25.08.2020, nrdepozit a 2019 0052 din 21.06.2019.
     

Teze ale comunicărilor la conferinţe, simpozioane:

  1. Gîrbu, V.; Ungur, N.; Kulcitki, V.; Renaud, Ph. Radical perfluoroalkylation of ent-kaurenoate derivatives. In: International Conference “Achievements and perspectives of modern chemistry”, 9-11 october 2019, Moldova, p. 219. ISBN 978-9975-62-428-2.
  2. Gîrbu, V.; Ungur, N.; Kulcitki, V.; Renaud, Ph. Radical transformations of ent-isocopalic diterpenes. In: International Conference “Achievements and perspectives of modern chemistry”, 9-11 october 2019, Moldova, p. 220. ISBN 978-9975-62-428-2.
  3. Morarescu, O.; Grinco, M.; Kulciţki, V.; Ungur, N. Synthesis of a C12-functionalized norscalarane from sclareol. In: International Conference “Achievements and perspectives of modern chemistry”, 9-11 october 2019, Moldova, p. 230. ISBN 978-9975-62-428-2.
  4. Aricu, A.; Secara, E.; Kuchkova, K.; Barba, A.; Dragalin, I.; Ungur, N. Synthesis of some new drimane compounds with 1,3,4-oxadiazole fragment. In: International Conference “Achievements and perspectives of modern chemistry”, 9-11 october 2019, Moldova, p. 238. ISBN 978-9975-62-428-2.
  5. Aricu, A.; Kuchkova, K.; Secara, E.; Barba, A.; Dragalin, I.; Ungur, N. Synthesis of some new homodrimane sesquiterpenoids with 1,3,4-oxadiazole fragment. In: International Conference “Achievements and perspectives of modern chemistry”, 9-11 october 2019, Moldova, p. 239. ISBN 978-9975-62-428-2.
  6. Morarescu, O.; Grinco, M.; Kulciţki, V.; Garbuz, O.; Gudumac, V.; Gulea, A.; Ungur, N. Synthesis of halogenated derivatives of ent-kaur-16-en-19-oic acid. In: International Conference “Achievements and perspectives of modern chemistry”, 9-11 october 2019, Moldova, p. 246. ISBN 978-9975-62-428-2.
  7. Morărescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Unusual Remote C-H Functionalization of Manoyl Oxides. In: IUPAC International Symposium on Biiorganic Chemistry – ISBOC-11, 27-29 september,2017. Konstanz, Germany. Abstracts of Communication, p. 145.
  8. Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Expanding Structural Diversity of ent-Kaurane Diterpenoids by Free Radical Chemistry. In: IUPAC International Symposium on Biiorganic Chemistry – ISBOC-11, 27-29 september, 2017. Konstanz, Germany. Abstracts of Communication, p. 149.
  9. Kulciţki, V.; Sîrbu, T.; Gîrbu, V.; Ungur, N.; Rusu, V. A Biomimetic Synthesis of Halimanic Bicyclic Core. In: IUPAC International Symposium on Biiorganic Chemistry – ISBOC-11, 27-29 september, 2017. Konstanz, Germany. Abstracts of Communication, p. 136.
  10. Morărescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Unusual Remote C-H Functionalization of Manoyl Oxides by “Travelling” Radical. In: Villars Summer School “Trends in Organic Synthesis”. August 27-31, 2017, Villars-Sur-Ollon, Switzerland. Abstracts of Communication, p.14.
  11. Morărescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Structural Modification of ent-Kaurane Diterpenoids by Atom Transfer Radical Additions. In: : Villars Summer School “Trends in Organic Synthesis”. August 27-31, 2017, Villars-Sur-Ollon, Switzerland. Abstracts of Communication, p. 28.
  12. Fulga, A.; Gorincioi, E.; Barba, A.; Dragalin, I.; Ungur, N. Capitalization of the Lavender Wastes in Solving Tasks of Ursolic Acid Chemistry. In: Abstract Book of the 6th International Conference Ecological & Enviromental Chemistry, Chișinău, Moldova, March 2-3, 2017, p. 157.
  13. Grinco, M.; Barbă, A.; Ungur, N.; Kulciţki, V. Lignin ozonolysis in deep eutectic solvents. In: Abstract Book of the 6th International Conference Ecological & Enviromental Chemistry, Chișinău, Moldova, March 2-3, 2017, p. 187-188.
  14. Gîrbu, V.; Pruteanu, E.; Ungur, N.; Barbă, A.; Kulcițki, V. Terpene Ozonolysis in Green Solvents. In: Abstract Book of the 6th International Conference Ecological & Enviromental Chemistry, Chișinău, Moldova, March 2-3, 2017, p. 229.
  15. Morarescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Unusual Remote C-H Functionalization of Manoyl Oxides. IUPAC International Symposium on Biiorganic Chemistry - ISBOC-11, 27-29 September, 2017. Konstanz, Germany. Abstracts of Communication, p. 145.
  16. Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Expanding Structural Diversity of ent-KauraneDiterpenoids by Free Radical Chemistry. IUPAC International Symposium on Biiorganic Chemistry - ISBOC-11, 27-29 September, 2017. Konstanz, Germany. Abstracts of Communication, p. 149.
  17. Kulciţki, V.; Sîrbu, T.; Gîrbu, V.;Ungur, N.; Rusu, V. A Biomimetic Synthesis of Halimanic Bicyclic Core. IUPAC International Symposium on Biiorganic Chemistry - ISBOC-11, 27-29 September, 2017. Konstanz, Germany. Abstracts of Communication, p. 136. 
  18. Morărescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Unusual Remote C-H Functionalization of Manoyl Oxides by "Travelling" Radical. Villars Summer School "Trends in Organic Synthesis". August 27-31, 2017 Villars-sur-Ollon, Switzerland. Abstracts of Communication, p.14.
  19. Morărescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Structural Modification of ent-KauraneDiterpenoids by Atom Transfer Radical Additions. Villars Summer School "Trends in Organic Synthesis". August 27-31, 2017, Villars-sur-Ollon, Switzerland. Abstracts of Communication, p. 28.
  20. Gîrbu, V.; Pruteanu, E.; Ungur, N.; Barbă, A.; Kulciţki, V. Green solvents in natural product transformations. Terpene ozonolysis in dimethylcarbonate. XXXIV-th Romanian Chemistry Conference, October 4-7,Călimăneşti-Căciulata, Vâlcea, Romania. Abstracts of communication, 2016, p.6.
  21. Grinco, M.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Barbă, A.; Kulciţki, V. Ozonolysis in deep eutectic solvents: from terpenes to lignin. XXXIV-th Romanian Chemistry Conference, October 4-7, Călimăneşti-Căciulata, Vâlcea, Romania. Abstracts of communication,2016, p.19.
  22. Gîrbu, V.;Grinco, M.; Ungur, N.; Kulciţki, V.; Renaud, P. Generating diversity in natural product scaffolds. Synthesis of ent-kauranic derivatives functionalized with triazole fragments. International symposium “Medicinal plants. Present and perspectives”, september 6-9, Piatra Neamt, Romania. Abstracts of communication,2016, p.144.
  23. Morarescu, O.; Gîrbu, V.; Pruteanu, E.; Ungur, N.; Kulciţki, V.; Renaud, P. Towards mimics of forskolin. Efficient free radical alkylations of manoyloxides. International symposium “Medicinal plants. Present and perspectives”, september 6-9, Piatra Neamt, Romania. Abstracts of communication,2016, p.126.
  24. Pruteanu, E.; Gîrbu, V.; Ungur, N.; Kulciţki, V.; Renaud, P. Generating diversity in natural product scaffolds. Efficient C-17 alkylations of ent-kaur-16-enic derivatives. International symposium “Medicinal plants. Present and perspectives”, september 6-9, Piatra Neamt, Romania. Abstracts of communication,2016, p.88.
  25. Arîcu, A. N.; Kuchkova, K. I.; Barba, A. N.; Secara, E. S.; Dragalin, I. P.; Ungur, N.; Vlad, P. F. Synthesis of 8,9-bicyclohomofarnesenic acid guanidine derivatives from norambreinolide. The XXXIV-th Romanian Chemistry Conference, Calimanesti-Caciulata, Romania, October 4-7, 2016, p. 9.
  26. Arîcu, A. N.; Kuchkova, K. I.; Barba, A. N.; Secara, E. S.; Dragalin, I. P.; Ungur, N.; Vlad, P. F. Synthesis of guanidine derivatives of 12-amino-11-dihomodrimane-8α-ol and 13-amino-14,15-dinorlabd-8(9)-ene. The XXXIV-th Romanian Chemistry Conference, Calimanesti-Caciulata, Romania, October 4-7,2016, p. 22.
  27. Fulga, A.; Gorincioi, E.; Barba, A.; Dragalin, I.; Ungur, N.Capitalization of the Lavender Wastes in Solving Tasks of Ursolic Acid. Abstracts on the 21th ICSI National Conference Communications “Progress in Cryogenics and Isotopes Separation”. Călimăneşti - Ramnicu, Romania, 19-21 October, 2016, p.78-79.
  28. Harghel, P.; Grinco, M.; Ungur, N.; Kulciţki, V. Synthesis of highly functionalized perhydrindanic units by a degradation-cyclization approach. 16-th Tetrahedron Symposium Challenges in Bioorganic & Organic Chemistry, 16-19 June2015 | Grand Hyatt Berlin, Germany. P3. p.143. 
  29. Aricu, A. N.; Kuchkova, K. I.; Barba, A. N.; Gorincioi, E. C.; Dragalin, I. P.; Ungur, N. D.; Vlad, P. F. Synthesis of 8,9- Bicyclohomofarnezenic Acid Hydrazide from Norambreinolide. The XVIII-th International Conference "Physical Methods in Coordination and Supramolecular Chemistry”. Book of Abstracts. October 8–9, 2015. Chişinău, Moldova. P6. p. 35.
  30. Aricu, A. N.; Kuchkova, K. I.; Barba, A. N.; Gorincioi, E. C.; Dragalin, I. P.; Ungur, N. D.; Vlad, P. F. Synthesis of 11-Dihomodriman-8-ol-12-one Derivatives with Azine and Hydrazide Fragments. The XVIII-th International Conference "Physical Methods in Coordination and Supramolecular Chemistry”. Book of Abstracts. October 8–9, 2015. Chişinău, Moldova. P7. p. 36.
  31. Grinco, M.; Gîrbu, V.; Barba, A.; Gorincioi, E.; Ungur, N. Convenient Synthesis of Methyl (8S,9R,13S,14R)-4,4,8,9,13-Pentamethyl-20(109)-abeo-ent-isocopala-5(10),11(12)-dien-15β-oate. The XVIII-th International Conference "Physical Methods in Coordination and Supramolecular Chemistry”. Book of Abstracts. October 8–9, 2015. Chişinău, Moldova. P40. p. 69.
  32. Morarescu, O. Grinco, M.; Lunganu, M.; Ungur, N. NaIO4/LiBr-Supported Functionalization of ent-Kaur-16-en-19-oic Acid. The XVIII-th International Conference "Physical Methods in Coordination and Supramolecular Chemistry”. Book of Abstracts. October 8–9, 2015. Chişinău, Moldova. P79. p. 108.  

Naționale:

  1. ANCD 20.80009.8007.03. Noi substanțe cu potențial preventive șiterapeutic în baza compușilor naturali de origine vegetală și a metodelor moderne de sinteză organică
    Perioada de realizare: 2020-2023
    Conducător de proiect: Dr. habilitat Veaceslav Kulcițki

  2. CSSDT/15.817.02.14A Elaborarea metodelor de obţinere a terpenoidelor valoroase prin valorificarea resurselor renovabile din Republica Moldova
    Perioada de realizare: 2015-2019
    Conducător: Dr. habilitat, conf. cerc. Nicon UNGUR

Internationale:

  1. AȘM-CNCI/18.80013.16.02.02/it Sinteza terpenoidelor guanidinice cu activitate biologică relevantă şi potențial terapeutic
    Perioada de realizare: 2018-2019
    Conducător: Dr. habilitat, conf. cerc. Nicon UNGUR

  2. AȘM-CNCI/15.820.16.02.02/it Sinteza terpenoidelor guanidinice cu activitate biologică relevantă şi potențial terapeutic
    Perioada de realizare: 2015-2016
    Conducător: Dr. habilitat, conf. cerc. Nicon UNGUR

  3. SCOPES/IZ73Z0-152346. Modificarea compuşilor naturali mediată de radicali liberi.
    Perioada de realizare: 2015-2016;
    Conducător: Dr. habilitat, conf. cerc. Veaceslav KULCIȚKI